Results 161 to 170 of about 122,773 (309)

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

open access: yesMolecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang   +4 more
wiley   +1 more source

Prioritizing Modifiable Risk Factors for Cardiovascular Diseases in Adults With Hypertension: A Prospective Cohort Study

open access: yesMed Research, EarlyView.
This study examined the relative contributions of modifiable risk factors to cardiovascular diseases in adults with hypertension. More favorable risk factor profiles were consistently associated with lower risks across all outcomes. Beyond blood pressure, nicotine exposure showed comparatively larger population attributable fractions.
Shengtao Wei   +10 more
wiley   +1 more source

Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus

open access: yesMedicine Advances, EarlyView.
Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu   +4 more
wiley   +1 more source

Endoscopic small bowel therapies for type 2 diabetes

open access: yesNutrition in Clinical Practice, EarlyView.
Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel   +4 more
wiley   +1 more source

Musculoskeletal Outcomes of Glucagon‐Like Peptide‐1 Receptor Agonists Versus Other Antiobesity Agents in Nondiabetic Adults

open access: yesObesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the association of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) with risks of osteoporosis, major osteoporotic fractures, and degenerative musculoskeletal disorders in nondiabetic adults with obesity compared with other obesity medications.
Jie‐Syuan Wu   +5 more
wiley   +1 more source

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