Results 151 to 160 of about 6,301 (229)

Interstitial lung disease and CDK4/6 inhibitors in the treatment of breast cancer

Expert Opinion on Drug Safety, 2023
Introduction CDK4/6 inhibitors have changed the treatment paradigm of many patients living with metastatic and early-stage high-risk hormone receptor (HR)-positive breast cancer.
I. Schlam, A. Giordano, S. Tolaney
semanticscholar   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Metabolically programmed polyamine analogue antidiarrheals.

Journal of Medicinal Chemistry, 1996
The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
Raymond J. Bergeron, Guo-Wei Yao, Hua Yao, W. Weimar, C. Sninsky, B. Raisler, Yang Feng, Qianhong Wu, Feng-Lan Gao   +8 more
semanticscholar   +3 more sources

Antidiarrheal Effects of Dihydroergotamine

The Journal of Clinical Pharmacology, 1977
Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
F, Lechin, B, Van Der Dijs, A, Bentolila, F, Peña   +3 more
openaire   +2 more sources

Antidiarrheal therapy

Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
openaire   +2 more sources

Antidiarrheal Drug Therapy

Current Gastroenterology Reports, 2017
Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
openaire   +2 more sources

Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.

The Journal of Pharmacology and Experimental Therapeutics, 1979
Three synthetic antidiarrheals, diphenoxylate, loperamide and SC 27166, and two narcotics, morphine and codeine, were evaluated in rats by the intravenous and oral route for specificity and duration of their antidiarrheal, opiate-like and acute toxic effects.
C J, Niemegeers, J L, McGuire, J J, Heykants, P A, Janssen   +3 more
openaire   +2 more sources

Antimicrobial and Antidiarrheal drugs Survey

World Journal of Pharmaceutical Sciences, 2022
Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose.
Suthar Mona, Makwana Rajeshree, Jain Priyanshi, Dholekar Ekta   +3 more
openaire   +1 more source

Outcomes following two-stage surgical approaches in the treatment of pediatric ulcerative colitis.

Journal of Pediatric Surgery, 2019
INTRODUCTION Surgery for the treatment of ulcerative colitis (UC) can be performed in one-, two-, or three-stage procedures [1]. The more traditional approach is a total proctocolectomy and creation of an ileo pouch-anal anastomosis and diverting stoma ...
Nora Bismar, J. Knod, Ashish S. Patel, D. Schindel   +3 more
semanticscholar   +1 more source