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Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH)

European Journal of Clinical Pharmacology, 2011
Arginine vasopressin (AVP) is the major physiological regulator of renal water excretion and blood volume. The AVP pathways of V(1a)R-mediated vasoconstriction and V(2)R-induced water retention represent a potentially attractive target of therapy for edematous diseases.
Natig Gassanov   +2 more
exaly   +4 more sources

Effects of an oral vasopressin receptor antagonist (OPC‐31260) in a dog with syndrome of inappropriate secretion of antidiuretic hormone

Australian Veterinary Journal, 2000
ObjectiveThe syndrome of inappropriate secretion of antidiuretic hormone is a rare disorder in dogs characterised by hypo‐osmolality and persistent arginine vasopressin production in the absence of hypovolaemia and/or hypotension. The study describes the efficacy and safety of the nonpeptide selective arginine vasopressin V2receptor antagonist OPC ...
Peter J Irwin, L M Fleeman
exaly   +6 more sources

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

Bioorganic and Medicinal Chemistry Letters, 2005
Kosuke Kanuma, Yoshinori Sekiguchi
exaly  

Growth hormone secretagogue receptor antagonists

Expert Opinion on Therapeutic Patents, 2012
Luca Costantino
exaly  

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