Results 1 to 10 of about 2,089 (139)

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes [PDF]

Biomedicines, 2023
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are
Guiscard Seebohm, Bernhard Wunsch, Nadine Ritter   +2 more
exaly   +4 more sources

Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement [PDF]

Nature Communications, 2022
The dearomative functionalization of aromatic compounds represents a challenging transformation, as it typically needs to overcome a great kinetic barrier.
Qiu Shi, Zhehui Liao, Zhili Liu, Jiajia Wen, Chenguang Li, Jiamin He, Jiazhen Deng, Shan Cen, Tongxiang Cao, Jinming Zhou, Shifa Zhu   +10 more
doaj   +2 more sources

Benzazepines Derivatives: Synthetic Strategy, Structural-Activity Relationships, and Medical Potential as Dopamine and Serotonin Receptor Modulators [PDF]

ACS Omega
Shweta Singh Verma, Amit Verma, Surendra Kumar Verma, Syed Misbahul Hasan, Lavkush Verma, Mohd Anas   +5 more
doaj   +2 more sources

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Results in Chemistry, 2022
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh   +5 more
doaj   +1 more source

Unravelling benzazepines and aminopyrimidine as multi-target therapeutic repurposing drugs for EGFR V774M mutation in neuroglioma patients [PDF]

BioImpacts
Introduction: Neuroglioma, a classification encompassing tumors arising from glial cells, exhibits variable aggressiveness and depends on tumor grade and stage.
Jitender Singh, Krishan L Khanduja, Pramod K Avti   +2 more
doaj   +1 more source

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compounds, C22H29NO2 (3) and C22H29NO2 (4) [systematic names: (1S*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol and (1R*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol, are
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C25H27NO4S, which crystallized as a racemate, the relative configuration of the adjacent OH and CH3 groups on the azepine ring is trans. The seven-membered azepin ring has a chair-like conformation. The planar aromatic rings of the
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. [PDF]

Org Lett, 2023
Suárez-Lustres A, Martínez-Yáñez N, Velasco-Rubio Á, Varela JA, Saá C.   +4 more
europepmc   +1 more source

Asymmetric synthesis of trans-3,4-disubstituted tetrahydro-2-benzazepines

ARKIVOC, 2010
David Dumoulin, Stéphane Lebrun, Axel Couture, Eric Deniau, Pierre Grandclaudon   +4 more
doaj   +1 more source

Modern Friedel-Crafts chemistry. Part 35. New synthetic approach to substituted indolo[2,1-a][2]benzazepines and indolo[2,1-a]isoquinolines via Friedel-Crafts cyclialkylations

ARKIVOC, 2012
Hassan A. K. Abd El-Aal, * Ali A. Khalaf, Talaat I. El-Emary   +2 more
doaj   +1 more source