Results 21 to 30 of about 2,089 (139)
British Journal of Pharmacology, Volume 182, Issue 11, Page 2503-2523, June 2025.Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla +7 more
wiley +1 more source
Asian Journal of Organic Chemistry, Volume 14, Issue 3, March 2025.This review presents an analysis of ten recent total syntheses of cephalotaxine‐type alkaloids published between 2021 and 2024. The structural diversification strategies developed during this period are described. Additionally, a new structural classification system for this alkaloid class is proposed.
Yeju Oh, Anagha Reneesh, Hongjun Jeon
wiley +1 more source
Phenol (bio)isosteres in drug design and development
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.This review explores the pivotal role of phenol bioisosteres in drug design, highlighting their potential to overcome the limitations of phenolic compounds, such as poor bioavailability and rapid metabolism. By examining diverse bioisosteric replacements, from benzimidazolones to quinolinones, it is demonstrated how these modifications enhance drug ...
Calvin Dunker +2 more
wiley +1 more source
Optimized psilocybin production in tryptophan catabolism‐repressed fungi
Microbial Biotechnology, Volume 17, Issue 11, November 2024.Here, we developed an in vivo psilocybin production chassis, based on repression of l‐tryptophan catabolism. By genome mining, we identified two aminotransferase ARO8/9 orthologs in Aspergillus nidulans involved in l‐tryptophan catabolism. Double deletion of the aminotransferase genes aroH1 and aroH2 resulted in a 10‐fold increased psilocybin ...
Slavica Janevska +12 more
wiley +1 more source
Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review
ChemMedChem, Volume 19, Issue 9, May 2, 2024.Searching for a cure for neuroblastoma: This review highlights the urgent need to find a cure for high‐risk neuroblastoma. It provides an overview of the current treatment available and the drug discovery approach of seven drugs that reached clinical trial.
A. Gerges, U. Canning
wiley +1 more source
Review on allosteric modulators of dopamine receptors so far
Health Science Reports, Volume 7, Issue 3, March 2024.Abstract Background Contemporary research is predominantly directed towards allosteric modulators, a class of compounds designed to interact with specific sites distinct from the orthosteric site on G protein‐coupled receptors. These allosteric modulators play a pivotal role in influencing diverse pharmacological effects, such as agonism/inverse ...
Fentaw Girmaw
wiley +1 more source
ChemBioChem, Volume 25, Issue 2, January 15, 2024.We herein report the identification of UR‐NR435 (25), a SCH‐23390‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D1R. Single‐digit nanomolar binding affinity could be determined in radioligand competition binding and molecular brightness studies at D1‐like receptors.
Niklas Rosier +11 more
wiley +1 more source
Synthesis of Chiral Tetrahydro-3-benzazepine Motifs by Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Ene-carbamates. [PDF]
Org Lett, 2022 Peters BBC +3 more
europepmc +1 more source
Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C-H Activation/Cycloaddition Reactions. [PDF]
J Am Chem Soc, 2022 González JM +4 more
europepmc +1 more source