Results 11 to 20 of about 2,084 (139)
Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications
Analytical Science Advances, Volume 7, Issue 1, June 2026.ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
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Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye +3 more
wiley +1 more source
Bulletin of the Korean Chemical Society, Volume 47, Issue 4, Page 384-395, April 2026.This review summarizes microwave‐assisted transition‐metal catalysis for constructing N‐ and O‐heterocycles, highlighting rapid C–H and pre‐activated C–X activation, improved selectivity, and green synthetic efficiency. Abstract Microwave‐assisted organic synthesis provides a rapid and sustainable platform for synthesizing various heterocycles ...
Woo‐Jin Park, Ye Ri Han, Hyejeong Lee
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Sulfur Ylides in Skeletal‐Editing—Ring Expansion Reactions
Helvetica Chimica Acta, Volume 109, Issue 3, March 2026.Sulfur ylides (S‐ylides) are emergent diazo surrogates that enable skeletal editing and ring expansion with safer handling and broad functional group tolerance. This perspective covers pioneer works and highlights recent advances in the field, while outlining key challenges and future directions that may redefine the role of S‐ylides in modern ...
Arsala Kamal +3 more
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The Chemical Record, Volume 25, Issue 12, December 2025.Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür +3 more
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Angewandte Chemie, Volume 136, Issue 12, March 18, 2024.Asymmetric deprotonation of N‐benzyl urea derivatives of nitrogen heterocycles leads to enantioselective insertion of the benzylic substituent into an aromatic C−N bond. Treatment of the ring‐expanded products induces a stereospecific ring‐contraction that results in an overall asymmetric enantioselective one‐carbon enlargement of the heterocycle ...
Rajendra K. Mallick +2 more
wiley +2 more sources
Multistep Reactions Initiated by Amine‐Based Organometallic Methods
European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho +3 more
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Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates
ChemCatChem, Volume 17, Issue 15, August 7, 2025.The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell +3 more
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The Chemical Record, Volume 25, Issue 8, August 2025.The stabilization of precursors substituted with 2‐, 1‐naphthol via partially aromatic ortho‐quinone methide intermediate was tested with different cyclic imines in [4+2] cycloaddition.8‐Hydroxyquinoline as a formal 1‐naphthol analogue in Mannich reaction was tested.The formed Mannich bases substituted with 2‐ and 1‐naphthol, 5‐chloro‐8 ...
Dóra Hegedűs +3 more
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British Journal of Pharmacology, Volume 182, Issue 11, Page 2503-2523, June 2025.Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla +7 more
wiley +1 more source