Results 11 to 20 of about 3,116 (182)

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source

A hydrazine-free Wolff–Kishner reaction suitable for an undergraduate laboratory [PDF]

, 2016
A Wolff–Kishner reaction that does not require hydrazine has been developed. The reaction sequence has two steps; formation of a carbomethoxyhydrazone from methyl hydrazinocarboxylate and acetophenone, then decomposition of this intermediate by treatment
Cranwell, Philippa B., Russell, Andrew T.   +1 more
core   +1 more source

Review on allosteric modulators of dopamine receptors so far. [PDF]

Health Sci Rep
Abstract Background Contemporary research is predominantly directed towards allosteric modulators, a class of compounds designed to interact with specific sites distinct from the orthosteric site on G protein‐coupled receptors. These allosteric modulators play a pivotal role in influencing diverse pharmacological effects, such as agonism/inverse ...
Girmaw F.
europepmc   +2 more sources

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. [PDF]

, 2016
RATIONALE: Antenatal exposure to the glucocorticoid dexamethasone dramatically increases the number of mesencephalic dopaminergic neurons in rat offspring.
Dalley, J.W., Dalley, J.W., Gillies, G.E., Gillies, G.E., Hensman, D., Hensman, D., Jupp, B., Jupp, B., Kentrop, J., Kentrop, J., McArthur, S., McArthur, S., Robbins, T.W., Robbins, T.W., Venus, B., Venus, B., Virdee, K., Virdee, K., Wilkinson, J., Wilkinson, J.   +19 more
core   +8 more sources

Impact of spermiogram and sperm function test in idiopathic recurrent pregnancy loss [PDF]

, 2015
Aims: To evaluate the role of sperm factors in idiopathic recurrent pregnancy loss cases. Methods: We recruited 100 male subjects where their female partners experienced 2 or more idiopathic pregnancy losses.
Chaithra, T. P, Kavitha, P., Malini, S. S., Sreenivasa, G.   +3 more
core   +1 more source

Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects [PDF]

, 2010
(±) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D1-like dopamine receptor agonistic activity. The precise mechanism for
Bernhard, Eric J., Chen, Xue-Qin, Hu, Guo-Yuan, Jin, Guo-Zhang, Neumeyer, John Leopold, Zhang, Ao, Zhang, Jing, Zhen, Xuechu   +7 more
core   +1 more source

Identifying translational science within the triangle of biomedicine [PDF]

, 2013
Background: The National Institutes of Health (NIH) Roadmap places special emphasis on “bench-to-bedside” research, or the “translation” of basic science research into practical clinical applications.
Weber, Griffin M
core   +2 more sources

Diversity-oriented synthesis of 1,3-benzodiazepines [PDF]

, 2017
© 2017 Elsevier Ltd A concise assembly of the 1,3-benzodiazepine core from A 3 -coupling-derived propargylamines and ortho-bromophenylisocyanates is described.
Li, Binbin, Liu, Chao, Pereshivko, Olga P, Peshkov, Vsevolod A, Van der Eycken, Erik V, Van Hecke, Kristof, Wang, Gaigai, Wang, Yingchun   +7 more
core   +2 more sources

Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines [PDF]

, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela J. A., Saá C. (2020). Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines. Adv. Synth. Catal., 362, 22, 4861-
Bremner J. B., Carlos Saá, Clayton T., Elgarf A. A., Griffin C. E., Jesús A. Varela, Mantaj J., Meyer A. G., Meyer A. G., Meyer A. G., Pareek A., Ram V. J., Yin P., Álvaro Velasco‐Rubio   +13 more
core   +1 more source

Designing organometallic compounds for catalysis and therapy [PDF]

, 2012
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam, Aird, Alama, Alama, Alberto, Allardyce, Allen, Allen, Ana M. Pizarro, Anand, Ang, Ang, Anna Louisa Noffke, Arancibia, Barragan, Barry, Barry, Barry, Barry, Bergamo, Bergamo, Betanzos-Lara, Betanzos-Lara, Betanzos-Lara, Brewster, Bugarcic, Bugarcic, Canivet, Carrión, Caruso, Casini, Casini, Casini, Chaplin, Chen, Chen, del Pozo, Desmard, Dorcier, Dorcier, Dougan, Dougan, Dyson, Erxleben, Feng, Fernandez, Filak, Fu, Fu, Fujii, Giannini, Gormen, Gossens, Grau, Grguric-Sipka, Grubbs, Gröger, Guichard, Guo, Guo, Habtemariam, Hambley, Hamels, Hanif, Hanif, Harris, Hartinger, Hashiguchi, Hayes, Hayward, Herman, Hindi, Hogan, Hollmann, Hu, Hull, Ito, Jafarpour, Jennerwein, Jira, Jungwirth, Kandioller, Kisova, Kljun, Kopf, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kröger, Kuninobu, Lee, Leiva, Li, Liu, Liu, Liu, Liu, Liu, Lo, Lo, Lummen, Lutz, Maenaka, Meggers, Meggers, Meggers, Melchart, Melchart, Melchart, Melendez, Mendes, Motterlini, Mross, Novakova, Novakova, Novakova, Noyori, Noyori, Oehninger, Ogo, Ogo, Olliaro, Page, Patiño, Peacock, Peacock, Peacock, Peacock, Pelletier, Peter J. Sadler, Petzold, Petzold, Pitto-Barry, Pitto-Barry, Pizarro, Plazuk, Rocamora-Reverte, Ruiz, Ruppert, Sandoval, Sanford, Sarsam, Schatzschneider, Schmid, Schäfer, Scolaro, Selander, Skinner, Sriskandakumar, Steckhan, Strohfeldt, Suss-Fink, Sweeney, Takebayashi, Tan, Therrien, Therrien, Toney, Top, Top, Top, Trnka, Turel, van der Donk, van Rijt, van Rijt, van Rijt, Vessières, Vougioukalakis, Vougioukalakis, Wang, Wang, Wang, Ward, Williams, Williams, Wong, Wu, Wu, Yabluchanskiy, Yamakawa, Yan, Yano, Yuasa, Zava, Zekri, Zhao, Zoeller   +188 more
core   +1 more source