Doping prevention: Experience of Antidoping Agency of Serbia [PDF]
Medicinski Podmladak, 2016 By signing the Copenhagen Declaration on Doping in Sport, in December 2003, the basis was created for the adoption of the Law on prevention of doping in sports.
Dikić Nenad
doaj +2 more sources
Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale Retatrutide (LY3437943) is a novel long‐acting triple incretin receptor agonist that targets the glucagon‐like peptide‐1 receptor (GLP‐1R), glucose‐dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). Its pronounced effects on body composition and metabolic health, combined with increasing off‐label use
Carneiro GRA +6 more
europepmc +2 more sources
Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes. [PDF]
Drug Test AnalBox and whiskers plots show the distributions of serum testosterone (T), dihydrotestosterone (DHT), androstenedione (A4), and the ratios of T/FDHT and T/A4. ABSTRACT Detection of androgen doping relies on mass spectrometry‐based methods to detect natural endogenous and exogenous androgens in urine and serum. To distinguish exogenous administration from
Handelsman DJ, Bermon S.
europepmc +2 more sources
Detection of Testosterone Esters in Urine: Evidence of Trace-Level Detectability in Doping Control Samples. [PDF]
Drug Test AnalAn ultrasensitive LC‐MS/MS method for detecting testosterone esters (T‐esters) in urine at sub–pg/mL levels is presented. This approach, employing Girard P derivatization, provides the first evidence of T‐esters' trace‐level detectability in human urine.
Pecher D +3 more
europepmc +2 more sources
Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans. [PDF]
Biomed ChromatogrABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Okutan A +4 more
europepmc +2 more sources
Elimination Profile of Deflazacort and Metabolites in Urine and Plasma Following Oral Administration: Relevance to Sports Drug Testing. [PDF]
Drug Test AnalResults confirm that the MRL of 30 ng/mL for 21‐desacetyl‐deflazacort together with a 3‐day washout period is an appropriated strategy to detect oral deflazacort administration in sport competition. ABSTRACT Deflazacort (DEF) is a glucocorticoid prohibited in sports competitions when orally administered.
Coll S +5 more
europepmc +2 more sources
Detection of a Distinct Erythropoietin (EPO) Profile After Isoelectric Focusing in Patients With Familial Erythrocytosis. [PDF]
Drug Test AnalA basic EPO IEF profile was identified in patients with familial erythropoiesis linked to mutations in noncoding parts of EPO gene. Comparison of blood and urine EPO profiles from these patients differed from adult wild‐type EPO (WT) and from Eprex‐administered patients. Patients' EPO do not differ from WT EPO after analysis using SDS‐PAGE/SAR‐PAGE. It
Martin L +9 more
europepmc +2 more sources
Evaluating Transcriptomic Biomarkers for rHuEPO Detection: Assessing the Impact of Exercise and Altitude Exposure. [PDF]
Drug Test AnalA two‐stage transcriptomic filter comparing rHuEPO, exercise and altitude responses reduced 153 candidate genes to 50 that were unaffected by physiological stimuli. These retained transcripts offer focused biomarker leads to strengthen antidoping detection of rHuEPO.
Obratov D +4 more
europepmc +2 more sources
Adding conditional superannuation to the antidoping policy mix
, 2017 This article introduces and then examines a novel antidoping policy mechanism, based upon a conditional superannuation fund for professional athletes. It begins by presenting a theoretical case in favor of the scheme relative to the background of current
Liam J. Lenten (7186217) +2 more
core +8 more sources
Statistical Discrimination of Urinary Steroid Biomarkers in the Athlete Biological Passport: A Novel Approach to an Abnormal Steroid Profile Score (ASPS). [PDF]
Drug Test AnalThe study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
Hopker JG +3 more
europepmc +2 more sources