Results 51 to 60 of about 18,271 (248)

Therapeutic orphans no more: Revisiting the ethical justification for excluding pregnant women from pharmaceutical clinical trials

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract For six decades, pregnant women have been routinely excluded from pharmaceutical clinical trials, a practice rooted in a protectionist ethic that emerged after the thalidomide tragedy. This narrative review examines whether that exclusion remains ethically justifiable, drawing on the obstetric, pharmacological, and bioethical literature ...
Camila Kruger Cabar   +1 more
wiley   +1 more source

Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation

open access: yesDrug Design, Development and Therapy, 2018
Tom Ottoboni,1 Mary Rose Keller,2 Matt Cravets,3 Neil Clendeninn,4 Barry Quart5 1Pharmaceutical and Translational Sciences, Heron Therapeutics, Inc., San Diego, CA, USA; 2Clinical Operations, Heron Therapeutics, Inc., San Diego, CA, USA; 3Biometrics ...
Ottoboni T   +4 more
doaj  

Discrepant Urinary Findings Between Dipstick Protein and Sulfosalicylic Acid Test in a Patient With Hyaline Casts: A Case Report

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
In this post‐transplant patient, increased hyaline casts with negative dipstick protein but positive SSA testing occurred during evolving acute kidney injury and resolved with renal recovery. This discordant urinalysis pattern may warrant confirmatory protein testing and correlation with serial renal function in patients at high risk of AKI.
Yifei Jia   +6 more
wiley   +1 more source

Repurposing the Antiemetic Metoclopramide as an Antiviral Against Dengue Virus Infection in Neuronal Cells

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Dengue virus (DENV) is transmitted by Aedes mosquitoes to humans and is a threat worldwide. No effective new drugs have been used for anti-dengue treatment, and repurposing drugs is an alternative approach to treat this condition.
Ting-Jing Shen   +14 more
doaj   +1 more source

Exploring women's experiences and perceptions regarding the pharmacological management of hyperemesis gravidarum: a qualitative study

open access: yesJournal of Pharmacy Practice and Research, EarlyView.
Abstract Background Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting in pregnancy with potential sequelae including hypovolaemia, electrolyte imbalance, and malnutrition, which can result in adverse maternal–foetal outcomes. Aim To explore Australian women's experiences and perceptions regarding the pharmacological management of HG ...
Timothy R. McNamara   +5 more
wiley   +1 more source

Cancer therapy, vomiting, and antiemetics

open access: yes, 1990
Both radiotherapy and chemotherapy for cancer are capable of causing nausea and vomiting. With both treatment modalities, the nausea and vomiting is thought to be a second-order process rather than being due to direct stimulation of neuromechanisms that
David J. Stewart
core   +1 more source

Supplementary material to 'Piechotta et al. Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis'

open access: yes, 2021
Supplementary material 'Piechotta et al. Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis. Cochrane Database of Systematic Reviews.
Kathrin Kuhr   +8 more
core   +1 more source

Učinak pentadekapeptida BPC 157 na produljeni QT interval u štakora uzrokovan ponavljanim dozama antipsihotika i antiemetika [The influence of pentadecapeptide BPC 157 on prolonged QT interval in rats caused with repetitive doses of antipsyhotics and antiemetics] [PDF]

open access: yes, 2015
Repetitive use of different neuroleptics and antiemetics can lead to prolonged QT interval. The aims of our research were to investigate whether the use of pentadecapeptide BPC 157 can prevent the occurence of prolonged QT interval and is this effect ...
Strinić, Dean
core   +1 more source

Pediatric hereditary angioedema presenting as recurrent episodic abdominal pain and vomiting: Challenges in diagnosis and management

open access: yesJPGN Reports, EarlyView.
Abstract Recurrent episodic abdominal pain and vomiting, with symptom‐free intervals between attacks, represent common and often challenging presentations in children, typically leading to extensive workups without a clear etiology, as standard diagnostic algorithms fail to include rare systemic conditions. We present the challenging diagnostic odyssey
Julio Nestor Busaniche   +8 more
wiley   +1 more source

Methodologic issues in trials of antiemetics.

open access: yes, 1984
Studies of antiemetics require consideration of methodologic issues that may not be of concern in trials of antineoplastics. This paper illustrates how the strength of the results of these studies can be affected by (1) the types of patients studied, (2)
J L Pater, A R Willan
core   +1 more source

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