Results 51 to 60 of about 26,294 (312)

NEPA, a new fixed combination of netupitant and palonosetron, is a cost-effective intervention for the prevention of chemotherapy-induced nausea and vomiting in the UK

Drugs in Context, 2017
Background: The objective was to evaluate the cost-effectiveness of NEPA, an oral fixed combination netupitant (NETU, 300 mg) and palonosetron (PA, 0.5 mg) compared with aprepitant and palonosetron (APPA) or palonosetron (PA) alone, to prevent ...
Helene Cawston, Francois Bourhis, Jennifer Eriksson, Pierfrancesco Ruffo, Paolo D’Agostino, Marco Turini, Lee Schwartzberg, Alistair McGuire   +7 more
doaj   +1 more source

Navigating the Post‐BCMA/GPRC5D Landscape: Efficacy of Selinexor, Bortezomib, and Dexamethasone After Sequential Immunotherapy Failure in Penta‐Refractory Multiple Myeloma—A Multicenter Analysis

American Journal of Hematology, EarlyView.
ABSTRACT Patients with relapsed/refractory multiple myeloma (RRMM) who are penta‐drug refractory, defined as resistant to two proteasome inhibitors, two immunomodulatory agents, and an anti‐CD38 monoclonal antibody, face a dismal prognosis, particularly after exposure to T‐cell–redirecting therapies.
Maximilian Al‐Bazaz, Winfried Alsdorf, Lisa Leypoldt, Piet Sonnemann, Christoph Schaefers, Jule Artzenroth, Marie Harzer, Abdulaziz Kamili, Leandra Bartke, Leon Cords, Jan Vorwerk, Theo Leitner, Markus Maulhardt, Kerstin Brinkert, Annamaria Brioli, Tim Richardson, Udo Holtick, Stefan M. Hillmann, Hans Salwender, Cyrus Khandanpour, Carsten Bokemeyer, Katja Weisel, Ricardo Kosch   +22 more
wiley   +1 more source

Repurposing the Antiemetic Metoclopramide as an Antiviral Against Dengue Virus Infection in Neuronal Cells

Frontiers in Cellular and Infection Microbiology, 2021
Dengue virus (DENV) is transmitted by Aedes mosquitoes to humans and is a threat worldwide. No effective new drugs have been used for anti-dengue treatment, and repurposing drugs is an alternative approach to treat this condition.
Ting-Jing Shen, Ting-Jing Shen, Vu Thi Hanh, Vu Thi Hanh, Vu Thi Hanh, Thai Quoc Nguyen, Thai Quoc Nguyen, Thai Quoc Nguyen, Ming-Kai Jhan, Ming-Kai Jhan, Min-Ru Ho, Min-Ru Ho, Chiou-Feng Lin, Chiou-Feng Lin, Chiou-Feng Lin   +14 more
doaj   +1 more source

Effect of modified rapid sequence induction on postoperative nausea and vomiting in patients undergoing gynecologic laparoscopic surgery - A randomized controlled trial

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: The incidence of postoperative nausea and vomiting (PONV) ranges between 30% and 80%, and face mask ventilation (FMV) prior to intubation may be a significant risk factor.
R. Afshan, Pankaj Kundra, Stalin Vinayagam, Murali Subbaiah, Vikram Kate, K. M. Abdulbasith   +5 more
doaj   +1 more source

Profilaxia antiemética em cirurgia de abdome agudo: estudo comparativo entre droperidol, metoclopramida, tropisetron, granisetron e dexametasona Profilaxis antiemética en cirugía de abdomen agudo: estudio comparativo entre droperidol, metoclopramida, tropisetrón, granisetrón y dexametasona Prophylactic antiemetic therapy for acute abdominal surgery: a comparative study of droperidol, metoclopramide, tropisetron, granisetron and dexamethasone

Revista Brasileira de Anestesiologia, 2008
JUSTIFICATIVA E OBJETIVOS: A incidência de náuseas e vômitos pós-operatórios (NVPO) gira em torno de 30%. A profilaxia de NVPO foi objeto de múltiplos estudos, tanto para tentar diminuir esse problema como para comparar o índice custo-benefício do ...
Víctor Contreras-Domínguez, Paulina Carbonell-Bellolio   +1 more
doaj   +1 more source

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Diabetic gastroparesis: current challenges and future prospects

Clinical and Experimental Gastroenterology, 2018
Danny J Avalos,1 Irene Sarosiek,1 Priyadarshini Loganathan,2 Richard W McCallum1 1Division of Gastroenterology, Center for Neurogastroenterology and GI Motility, Texas Tech University Health Sciences Center, El Paso, TX, USA; 2Department of Internal ...
Avalos DJ, Sarosiek I, Loganathan P, McCallum RW   +3 more
doaj  

Italian multidisciplinary delphi consensus on home management of nausea and vomiting in children with acute gastroenteritis (NoEmesi Project)

Frontiers in Pediatrics
IntroductionVomiting in pediatric acute gastroenteritis (AGE) is a major driver of distress, caregiver anxiety, and failure of oral rehydration, while guidance for home management and pediatric antiemetic use is limited and influenced by regulatory ...
Ruggiero Francavilla, Fernanda Cristofori, Gian Luigi Marseglia, Gian Luigi Marseglia, Antonio D’Avino, Giorgio Ciprandi, Michele Miraglia del Giudice   +6 more
doaj   +1 more source

Bimodal release ondansetron for acute gastroenteritis among adolescents and adults: A randomized clinical trial [PDF]

, 2019
Importance: Vomiting resulting from acute gastroenteritis is commonly treated with intravenous antiemetics in acute care settings. If oral treatment were beneficial, patients might not need intravenous administered hydration or medication. Furthermore, a
Avarello, Jahn, Fathi, Reza, Hahn, Barry, House, Stacey L, Kalfus, Ira N, Lovato, Luis M, Meltzer, Andrew C, Miller, Joseph B, Plasse, Terry F, Raday, Gilead, Silverman, Robert A, Yan, Eric C   +11 more
core   +2 more sources

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source