Results 121 to 130 of about 645,736 (382)

Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris

Frontiers in Microbiology, 2019
Candida auris is an emerging multi-drug resistant yeast, that causes major issues regarding patient treatment and surface disinfection in hospitals. Indeed, an important proportion of C. auris strains isolated worldwide present a decreased sensitivity to
F. Chaabane, Artan Graf, L. Jequier, A. Coste   +3 more
semanticscholar   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters

Frontiers in Pharmacology
IntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng, Ruhua Wei, Yating Lu, Wen Cao, Kai Mo, Zheng Huang, Yane Qin, Xiaobu Lan   +7 more
doaj   +1 more source

Biocatalytic preparation and absolute configuration of enantiomerically pure fungistatic anti-2-benzylindane derivatives. Study of the detoxification mechanism by Botrytis cinerea [PDF]

, 2010
Enantiomerically pure 2-benzylindane derivatives were prepared using biocatalytic methods and their absolute configuration determined. (1R,2S)-2-Benzylindan-1-ol ((1R,2S)-2) and (S)-2-benzylindan-1-one ((S)-3) were produced by fermenting baker’s yeast.
Aleu, Bustillo, Bálint, Cristina Pinedo-Rivilla, Cui, De Gonzalo, Florey, Fronza, Isidro G. Collado, Josefina Aleu, Kokubun, Lamarche, Lorentzen, Manuel Grande Benito, Martínez, Nakamura, Osbourn, Petrignet, Pezet, Prost, Shieh, Smith, Snatzke, Stamb   +23 more
core   +2 more sources

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

First hospital outbreak of the globally emerging Candida auris in a European hospital [PDF]

, 2016
Background: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016.
Abdolrasouli, A, Armstrong-James, DPH, Chowdhary, A, Fisher, MC, Hagen, F, Hall, A, Meis, JF, Rhodes, JL, Ryan, L, Schelenz, S, Shackleton, J, Trimlett, R   +11 more
core   +2 more sources

Antibacterial and Antifungal Activities of Spices

International Journal of Molecular Sciences, 2017
Infectious diseases caused by pathogens and food poisoning caused by spoilage microorganisms are threatening human health all over the world. The efficacies of some antimicrobial agents, which are currently used to extend shelf-life and increase the ...
Qing Liu, Xiao Meng, Ya Li, Cai-Ning Zhao, Guo-Yi Tang, Huabin Li   +5 more
semanticscholar   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

EVALUATION OF ANTIFUNGAL ACTIVITY OF ANAEROBIC DIGESTATE AND ITS EFFECT ON GROWTH AND YIELD OF MAIZE [PDF]

, 2018
Pakistan is an agricultural country. The increased population leads to increasing demand for food. Unfortunately, crops are infected by different microbes and nutrient deficiency of soil adversely affects the yield of the crop ...
Badshah, Malik, Haq, Abdul, Khan, Alam, Zaffar, Nazia   +3 more
core  

Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]

, 2019
A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core   +4 more sources