Results 161 to 170 of about 473,247 (336)

Mycoticin, a New Antifungal Antibiotic

open access: bronze, 1954
R. C. Burke   +3 more
openalex   +1 more source

Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases

open access: yesAdvanced Science, EarlyView.
Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang   +13 more
wiley   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

open access: yesAdvanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng   +8 more
wiley   +1 more source

Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines

open access: yesInternational Journal of Nanomedicine, 2018
Katarzyna Niemirowicz-Laskowska,1 Katarzyna Głuszek,1 Ewelina Piktel,1 Karlis Pajuste,2 Bonita Durnaś,3 Grzegorz Król,3 Agnieszka Z Wilczewska,4 Paul A Janmey,5 Aiva Plotniece,2 Robert Bucki1 1Department of Microbiological and Nanobiomedical ...
Niemirowicz-Laskowska K   +9 more
doaj  

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

open access: yesAdvanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao   +11 more
wiley   +1 more source

Prediction of Lung Cancer Metastasis Risk Based on Single‐Cell Metabolic Profiling of Circulating Tumor Cells

open access: yesAdvanced Science, EarlyView.
A self‐developed CTC sorting and capture platform enabled single‐cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis‐specific metabolic signatures. A classification model developed from these signatures predicted lung cancer metastasis risk, outperforming traditional markers and total CTC counts (AUCs:89 brain = 0.74; bone = 0.92).
Yang Xu   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy