A Radical‐Based, Transition Metal‐Free Approach for Diaryl Ketone Synthesis
ChemSusChem, EarlyView.A sustainable and scalable one‐pot route to diverse diaryl ketones is described, proceeding via a distinctive radical process between aryl halides and benzonitriles, initiated by KOtBu/DMA and driven by air as the sole oxidant. Free from transition metals, peroxides, and carbon monoxide, this catalyst‐free and selective method exhibits broad functional
Dongjie Wang +4 more
wiley +1 more source
Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model
Barrier Immunity, EarlyView.ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia +4 more
wiley +1 more source
Transition Metal‐Free Ortho‐Deuteration of Electron‐Deficient N‐Heteroarenes
European Journal of Organic Chemistry, EarlyView.Herin, the metal‐free, selective deuteration of electron‐deficient N‐heteroaromatics is reported using O‐carbamate and carboxamide ortho‐directing groups (DGs), lithium 2,2,6,6‐tetramethylpiperidide as the base, and D2O as a green source of D+. The substrate scope includes 10 small molecule N‐heteroaromatic compounds and two pharmaceutically relevant ...
Žiga Oražem +5 more
wiley +1 more source
1,3‐Diazetidin‐2‐Ones: Synthetic Approaches and Therapeutic Promise within the Aza‐β‐Lactam Family
European Journal of Organic Chemistry, EarlyView.This review explores the synthesis, reactivity, and therapeutic potential of 1,3‐diazetidin‐2‐ones—an underexplored class of aza‐β‐lactams. Emphasis is placed on synthetic challenges, emerging methodologies, and their promise as β‐lactamase‐resistant scaffolds in medicinal chemistry. 1,3‐diazetidin‐2‐ones, overlooked members of the aza‐β‐lactam family,
Jozef Kristek, Jiří Pospíšil
wiley +1 more source
Novel Flavonol Derivatives Containing 1,3,4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation. [PDF]
ACS OmegaZhou Y +7 more
europepmc +1 more source
Low‐Carbon Agricultural Strategies: Toward Environmental Protection and Energy Efficiency
Energy Science &Engineering, EarlyView.Integration of agricultural engineering with renewable energy innovations. Sustainable irrigation and mechanization enhance resource‐use efficiency. Circular bioeconomy strategies mitigate emissions and improve soil health. Biocher and biostimulants strengthen resilience in sustainable agriculture.
Ravikumar Jayabal +2 more
wiley +1 more source
Correction: Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus. [PDF]
RSC Med ChemGoswami L +5 more
europepmc +1 more source
Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines
Environmental Toxicology and Chemistry, EarlyView.Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz +4 more
wiley +1 more source
Oral Candida carriage and resistance against common antifungal agents in hematopoietic stem cell transplantation recipients. [PDF]
Support Care CancerMauramo M +4 more
europepmc +1 more source