Results 171 to 180 of about 3,376,929 (374)

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Antifungal Resistance in Pulmonary Aspergillosis

Seminars in Respiratory and Critical Care Medicine
AbstractAspergilli may cause various pulmonary diseases in humans, including allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), and acute invasive pulmonary aspergillosis (IPA). In addition, chronic colonization may occur in cystic fibrosis (CF).
Verweij, Paul E, Song, Yinggai, Buil, Jochem B, Zhang, Jianhua, Melchers, Willem J G   +4 more
openaire   +5 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Bacillus based biocontrol on Brassica [PDF]

, 2008
Many bacterial strains have been shown to mediate protection to biotic stress and promote growth of plants. Different bacteria can mediate protection in different ways e.g. by inhibition, competition or increasing plant resistance.
Danielsson, Jesper
core  

Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009 [PDF]

, 2010
Ahmed S. Bueid, S. J. Howard, Caroline B. Moore, Malcolm Richardson, Elizabeth Harrison, Paul Bowyer, David W. Denning   +6 more
openalex   +1 more source

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

Advanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim, Hanjun Hwangbo, ByungJoon Choi, Dogeon Yoon, GeunHyung Kim   +4 more
wiley   +1 more source

Frequency and Antifungal Susceptibility Patterns of Candida Species Isolated from Clinical Samples of Patients Attending to a Tertiary Healthcare Setting in Karnataka, India

Journal of Nature and Science of Medicine
Context: Candida species are common pathogens causing a range of infections from mucocutaneous to systemic. The increasing antifungal resistance among Candida species presents a substantial challenge in healthcare settings.
Asem Ali Ashraf, Vimal Kumar Karnaker, Ganesh Ramanath, Anulekha Roy, Athira Raveendran, Sayantani Nag   +5 more
doaj   +1 more source

In vitro antifungal resistance profile of Candida strains isolated from Saudi women suffering from vulvovaginitis [PDF]

, 2020
Mohamed Taha Yassin, Ashraf Abdеl-Fattah Mostafa, Abdulaziz A. Al–Askar, Rashad Bdeer   +3 more
openalex   +1 more source