Results 1 to 10 of about 1,116,502 (236)
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť +2 more
doaj +7 more sources
Journal of Fungi, 2023 Due to their eukaryotic heritage, the differences between a fungal pathogen’s molecular makeup and its human host are small. Therefore, the discovery and subsequent development of novel antifungal drugs are extremely challenging.
Giel Vanreppelen +3 more
doaj +7 more sources
Repurposing antifungal drugs for cancer therapy
Journal of Advanced Research, 2023 Background: Repurposing antifungal drugs in cancer therapy has attracted unprecedented attention in both preclinical and clinical research due to specific advantages, such as safety, high-cost effectiveness and time savings compared with cancer drug ...
Ningna Weng +5 more
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QJM: An International Journal of Medicine, 1995 Introduction Fungi have been recognized as pathogens for many years. However, the incidence of fungal infections in the pediatric population has increased substantially due to the increased use of broad-spectrum antibiotics, immunosuppressive agents, hyperalimentation products, and central venous catheters in addition to the acquired ...
J T, Cross, S L, Hickerson, T, Yamauchi
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Antifungal Nanomaterials: Current Progress and Future Directions [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 Fungal infection poses a severe threat to human health worldwide resulting in a serious problem in clinic. Due to the limited arsenal of existing antifungal drugs, the nanomaterials were thus regarded as the candidate for developing new antifungal drugs.
Jia-Le Xu +4 more
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Antifungal drugs prescription pattern in a tertiary care teaching hospital in South India
National Journal of Physiology, Pharmacy and Pharmacology, 2023 Background: Fungal infections are a major threat to human health. Immunocompromised patients are more susceptible to fungal infections which may be from superficial to systemic fungal infections. Proper diagnosis and appropriate prescription is essential
Subashree A, Anuradha C R, Reena G R
doaj +1 more source
Prescribing Pattern of Antifungal Drugs in a Tertiary Care Teaching Hospital in Western India
Pharmacology and Clinical Pharmacy Research, 2023 Fungal infections are prevalent in a tropical country like India. Pharmacotherapy of fungal disease has been revolutionized by the introduction of relatively less toxic oral drugs, com- bination therapy, and new formulations of older agents.
Parth B. Patel +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Triazole antifungal drugs (TAD) are widely used to treat invasive fungal infections due to their broad antifungal spectrum and low toxicity. Despite their preference in the clinic, multiple Adverse Events (AE) are still reported each year.
Jianxing Zhou +8 more
doaj +1 more source
Development and research progress of anti-drug resistant fungal drugs
Journal of Infection and Public Health, 2022 With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year.
Xiangyi Cui +3 more
doaj +1 more source
Antifungal Drug Repurposing [PDF]
Antibiotics, 2020 Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including the generation of reactive oxygen species.
Jong H. Kim +7 more
openaire +3 more sources