Results 21 to 30 of about 1,116,502 (236)

Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]

, 2010
Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Sonashia Velho-Pereira, Nandkumar M. Kamat   +1 more
core   +1 more source

Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS

Metabolic Engineering Communications, 2019
In pharmaceutical industry, isepamicin is mainly manufactured from gentamicin B, which is produced by Micromonospora echinospora as a minor component of the gentamicin complex.
Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu, Tiangang Liu   +8 more
doaj   +1 more source

Pharmacodynamic Effects of Simulated Standard Doses of Antifungal Drugs against Aspergillus Species in a New In Vitro Pharmacokinetic/Pharmacodynamic Model [PDF]

, 2011
In conventional MIC tests, fungi are exposed to constant drug concentrations, whereas in vivo, fungi are exposed to changing drug concentrations.
Thomas J. Walsh, Emmanuel Roilides, Aristea Velegraki, Walsh, Thomas, Zerva, Loukia, Meletiadis, Joseph, Joseph Meletiadis, Roilides, Emmanuel, Rafal Al-Saigh, Velegraki, Aristea, Loukia Zerva, Al Saigh, Rafal   +11 more
core   +1 more source

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, Day, Jeremy, T. S. Harrison, J. Day, Loyse, A   +10 more
core   +1 more source

Fungal Infections as an Uprising Threat to Human Health: Chemosensitization of Fungal Pathogens With AFP From Aspergillus giganteus

Frontiers in Cellular and Infection Microbiology, 2022
Occurrence and intensity of systemic invasive fungal infections have significantly risen in recent decades with large amount of mortality and morbidity rates at global level.
Kavitha Dhandapani, Karthiga Sivarajan, Ramya Ravindhiran, Jothi Nayaki Sekar   +3 more
doaj   +1 more source

Antifungal Drugs and Drug-Induced Liver Injury: A Real-World Study Leveraging the FDA Adverse Event Reporting System Database

Frontiers in Pharmacology, 2022
Aims: We aimed to estimate the risk of drug-induced liver injury (DILI) from various antifungal treatments with azoles and echinocandins causing in real-world practice.Methods: We performed disproportionality and Bayesian analyses based on data from the ...
Zhi-Xuan Zhou, Zhi-Xuan Zhou, Xue-Dong Yin, Xue-Dong Yin, Yu Zhang, Yu Zhang, Qi-Hui Shao, Qi-Hui Shao, Xin-Yu Mao, Xin-Yu Mao, Wen-Juan Hu, Yun-Lin Shen, Bin Zhao, Zhi-Ling Li   +13 more
doaj   +1 more source

Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi [PDF]

, 2008
Background: In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely.
Borelli, Claudia, Korting, Hans Christian, Tietjen, K., Niewerth, M., Schaller, M., Lang-Fugmann, S., Tiemann, R., Fugmann, B., Baasner, B., Nocker, K., Berg, D.   +10 more
core   +1 more source

Pharmaceutical Pollution: Azole Antifungal Drugs and Resistance of Opportunistic Pathogenic Yeasts in Wastewater and Environmental Water

Applied and Environmental Soil Science, 2021
The occurrence of residual antifungal agents through indiscriminate prophylactic use and inappropriate disposal has been reported in wastewater treatment plants (WWTPs), surface water, and groundwater environments. Opportunistic pathogenic aquatic yeasts
Mzimkhulu E. Monapathi, Joseph C. Oguegbulu, Lilian Adogo, Michael Klink, Bamidele Okoli, Fanyana Mtunzi, Johannes S. Modise   +6 more
doaj   +1 more source

Drug-Drug Interaction of Antifungal Drugs

YAKUGAKU ZASSHI, 2005
This article reviews the in vitro metabolic and the in vivo pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole. In the in vitro interaction studies, the effects of antifungal drugs on specific activities of cytochrome P450s (CYPs), including CYP1A2, CYP2C9, CYP2C19,
Toshiro, Niwa, Toshifumi, Shiraga, Akira, Takagi   +2 more
openaire   +3 more sources