Results 31 to 40 of about 1,272,091 (279)
Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]
, 2011 The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli +15 more
core +2 more sources
In vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species [PDF]
, 2013 The strict nutritional requirements of Malassezia species make it difficult to test the antifungal susceptibility. Treatments of the chronic and recurrent infections associated with Malassezia spp. are usually ineffective. The objective of this study was
Rojas, Florencia +7 more
core +2 more sources
The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin [PDF]
, 2021 The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture.
Hoenigl, Martin +24 more
core +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Occurrence and intensity of systemic invasive fungal infections have significantly risen in recent decades with large amount of mortality and morbidity rates at global level.
Kavitha Dhandapani +3 more
doaj +1 more source
Applied and Environmental Soil Science, 2021 The occurrence of residual antifungal agents through indiscriminate prophylactic use and inappropriate disposal has been reported in wastewater treatment plants (WWTPs), surface water, and groundwater environments. Opportunistic pathogenic aquatic yeasts
Mzimkhulu E. Monapathi +6 more
doaj +1 more source
Drug-Drug Interaction of Antifungal Drugs
YAKUGAKU ZASSHI, 2005 This article reviews the in vitro metabolic and the in vivo pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole. In the in vitro interaction studies, the effects of antifungal drugs on specific activities of cytochrome P450s (CYPs), including CYP1A2, CYP2C9, CYP2C19,
Toshiro, Niwa +2 more
openaire +3 more sources
Identification and Elimination of Antifungal Tolerance in Candida auris
Biomedicines, 2023 Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi +3 more
doaj +1 more source
Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]
, 2013 Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse +9 more
core +1 more source
Heliyon, 2020 The human pathogenic yeast genus Malassezia may be an etiological agent of skin disorders and has received considerable attention from dermatologists in recent years.
Kaiqin Wang +12 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2021 BACKGROUND Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections.
Rodrigo Almeida-Paes +6 more
doaj +1 more source