Results 31 to 40 of about 92,209 (296)
Frontiers in Cellular and Infection Microbiology, 2022 Occurrence and intensity of systemic invasive fungal infections have significantly risen in recent decades with large amount of mortality and morbidity rates at global level.
Kavitha Dhandapani +3 more
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Applied and Environmental Soil Science, 2021 The occurrence of residual antifungal agents through indiscriminate prophylactic use and inappropriate disposal has been reported in wastewater treatment plants (WWTPs), surface water, and groundwater environments. Opportunistic pathogenic aquatic yeasts
Mzimkhulu E. Monapathi +6 more
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Identification and Elimination of Antifungal Tolerance in Candida auris
Biomedicines, 2023 Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi +3 more
doaj +1 more source
Drug-Drug Interaction of Antifungal Drugs
YAKUGAKU ZASSHI, 2005 This article reviews the in vitro metabolic and the in vivo pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole. In the in vitro interaction studies, the effects of antifungal drugs on specific activities of cytochrome P450s (CYPs), including CYP1A2, CYP2C9, CYP2C19,
Toshiro, Niwa +2 more
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Journal of Fungi, 2023 With only four classes of antifungal drugs available for the treatment of invasive systemic fungal infections, the number of resistant fungi is increasing, highlighting the urgent need for novel antifungal drugs.
Keiko Nakano +5 more
doaj +1 more source
Introduction to Antifungal Drugs [PDF]
Clinical Infectious Diseases, 2000 In the United States, only 10 antifungal drugs are currently approved by the Food and Drug Administration (FDA) for the therapy of systemic fungal infections. As shown in table 1, these drugs belong to 3 principal classes: polyenes, pyrimidines, and azoles.
openaire +2 more sources
Memorias do Instituto Oswaldo Cruz, 2021 BACKGROUND Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections.
Rodrigo Almeida-Paes +6 more
doaj +1 more source
Novel Antifungal Compounds Discovered in Medicines for Malaria Venture’s Malaria Box
mSphere, 2018 Similarities in fungal and animal cells make antifungal discovery efforts more difficult than those for other classes of antimicrobial drugs. Currently, there are only three major classes of antifungal drugs used for the treatment of systemic fungal ...
Eric H. Jung +3 more
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Missed Opportunities for Antifungal Stewardship during the COVID-19 Era
Antibiotics, 2023 Significant increases in antibacterial use were observed during the COVID-19 pandemic. However, subsequent analyses found this increase in antibiotic use to be excessive in comparison with the relatively low rates of bacterial coinfection.
Brandon K. Hawkins +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source