Results 51 to 60 of about 1,272,091 (279)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
An insight into new strategies and targets to combat antifungal resistance: A comprehensive review
European Journal of Medicinal Chemistry ReportsAntifungal drugs target specific components or processes within fungal cells to prevent or eliminate their growth. Various antifungal targets exist, including the cell membrane disrupted by drugs such as azoles and polyenes.
Deepali Nahar +7 more
doaj +1 more source
Antifungal resistance and clinical significance in small animals
German Journal of Veterinary Research, 2022 Fungal diseases have risen in conjunction with the increasing number of immunosuppressive diseases in human and animal populations. Despite the introduction of new antifungal agents in recent years, the incidence of fungal infections continues to ...
Yasemin Kaya +3 more
doaj +1 more source
, 2016 SMICs of antifungal drugs and sertraline against biofilms of 21 T. asahii isolates and the interactions of antifungal drugs with sertraline.
Rongya Yang (2825303) +3 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
, 2016 Interactions of antifungal drugs with sertraline on antifungal activities against T. asahii planktonic cells.
Rongya Yang (2825303) +3 more
core +1 more source
Tolerability and safety of antifungal drugs [PDF]
, 2013 When treating critically ill patients, as those with fungal infections, attention should be focused on the appropriate use of drugs, especially in terms of dose, safety, and tolerability.
Scaglione, Francesco
core +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Antifungal activity of nonantifungal drugs.
, 2003 The antifungal activity of synthetic, nonchemotherapeutic compounds, antineoplastic agents and antibacterial drugs, such as sulphonamides, has been known since the early 20th century (1932). In this context, the term "nonantifungal" is taken to include a
Afeltra, J., Verweij, P.E.
core +1 more source