Results 1 to 10 of about 134,309 (205)

Novel Antifungal Agents and Their Activity against Aspergillus Species

Journal of Fungi, 2020
There is a need for new antifungal agents, mainly due to increased incidence of invasive fungal infections (IFI), high frequency of associated morbidity and mortality and limitations of the current antifungal agents (e.g., toxicity, drug–drug ...
Roya Vahedi-Shahandashti, Cornelia Lass-Flörl   +1 more
doaj   +1 more source

Fungal Drug Response and Antimicrobial Resistance

Journal of Fungi, 2023
Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor, Amparo Pascual-Ahuir, Markus Proft   +2 more
doaj   +1 more source

Synthesis and antifungal activity investigation of a novel clotrimazole derivative

Mongolian Journal of Chemistry, 2014
Azole antifungal agents disrupt fungal ergosterol synthesis that is essential for the formation of fungal cell membrane by preventing 14-α-demethylase enzyme from binding to its substrate.
B Zoljargal, N Davaasuren
doaj   +1 more source

Cationic surfactants as antifungal agents [PDF]

, 2022
Fungi-in being responsible for causing diseases in animals and humans as well as environmental contaminations in health and storage facilities-represent a serious concern to health security.
Morcelle del Valle, Susana Raquel, Saparrat, Mario Carlos Nazareno, Fait, María Elisa, Bakás, Laura Susana, Garrote, Graciela Liliana   +4 more
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Cardiac arrhythmias of BCR-ABL inhibitors with or without triazole antifungal agents: A real-world pharmacovigilance study based on the food and drug administration adverse event reporting system database

SAGE Open Medicine
Objectives: Breakpoint Cluster Region (BCR)-Abelson tyrosine kinase (ABL) inhibitors are widely used in the treatment of blood cancers, particularly chronic myelogenous leukemia and are often combined with triazole antifungal agents to prevent fungal ...
Peitao Xie, Lishan Lu, Yixuan Tian, Rongrong Jia, Xuemei Tian, Pu Bai   +5 more
doaj   +1 more source

Trend of Candida species profiles and their susceptibility to various antifungals in Jakarta, Indonesia [PDF]

Current Medical Mycology
Background and Purpose: Fungal infections are prevalent in tropical countries, and their etiology depends on various factors, including the underlying cause and accompanying risk factors.
Conny Tjampakasari, Yeva Rosana, Mardiastuti Wahid   +2 more
doaj   +1 more source

Antifungal activity of some metabolites of higher fungi (Basidiomycetes) - an overview

Acta Societatis Botanicorum Poloniae, 2014
A series of compounds of different chemical structures showing antifungal activity were isolated from higher fungi (Basidiomycetes) fruit bodies. Among the microflora against which the examined metabolites showed effective activity, there are pathogenic ...
Teresa Florianowicz
doaj   +1 more source

Next-generation antifungal drugs: Mechanisms, efficacy, and clinical prospects

Acta Pharmaceutica Sinica B
Invasive fungal infections (IFIs) have become prominent global health threats, escalating the burden on public health systems. The increasing occurrence of invasive fungal infections is due primarily to the extensive application of chemotherapy ...
Xueni Lu, Jianlin Zhou, Yi Ming, Yuan Wang, Ruirui He, Yangyang Li, Lingyun Feng, Bo Zeng, Yanyun Du, Chenhui Wang   +9 more
doaj   +1 more source

Impact of first-line antifungal agents on the outcomes and costs of candidemia [PDF]

, 2012
Candida species are the leading causes of invasive fungal infection among hospitalized patients and are responsible for major economic burdens. The goals of this study were to estimate the costs directly associated with the treatment of candidemia and ...
한상훈
core  

Genetic Differentiation, Diversity, and Drug Susceptibility of Candida krusei

Frontiers in Microbiology, 2018
Candida krusei is a notable pathogenic fungus that causes invasive candidiasis, mainly due to its natural resistance to fluconazole. However, to date, there is limited research on the genetic population features of C. krusei.
Jie Gong, Meng Xiao, Meng Xiao, He Wang, He Wang, Timothy Kudinha, Timothy Kudinha, Yu Wang, Fei Zhao, Weiwei Wu, Lihua He, Ying-Chun Xu, Ying-Chun Xu, Jianzhong Zhang   +13 more
doaj   +1 more source