Diazocarbonyl and Related Compounds in the Synthesis of Azoles [PDF]
Molecules, 2021 Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo chemistry is the preparation of azoles from diazo compounds.
Mikhail Krasavin +2 more
exaly +4 more sources
Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles [PDF]
Molecules, 2020 The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Erik Van Der Eycken +2 more
exaly +4 more sources
Nuclear Quadrupole Resonance Spectroscopy: Tautomerism and Structure of Functional Azoles [PDF]
Crystals, 2019 The Nuclear Quadrupole Resonance spectroscopy data of functionalized azoles (imidazoles, triazoles and corresponding benzazoles) are reviewed and critically discussed. The possibility of studying the tautomerism of azoles by the NQR method is considered.
Lyudmila I. Larina
doaj +2 more sources
Pharmacovigilance analysis of myopathy associated with azoles and nonstatins interactions based on US FAERS database [PDF]
Scientific ReportsAzoles are first-line antifungal agents known to increase the risk of statin-related myopathy due to drug interactions. However, myopathy events have also been observed in patients using azoles without concurrent statin use, suggesting that azoles may be
Shen’ao Jing +8 more
doaj +2 more sources
Preparation and Utility of N-Alkynyl Azoles in Synthesis [PDF]
Molecules, 2019 Heteroatom-substituted alkynes have attracted a significant amount of interest in the synthetic community due to the polarized nature of these alkynes and their utility in a wide range of reactions.
Brandon Reinus, Sean M. Kerwin
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Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against Candida albicans [PDF]
AntibioticsBackground/Objectives: The diminished efficacy of azoles in treating fungal infections is attributed to the emergence of resistance among pathogenic fungi. Employing a synergistic approach with other compounds to enhance the antifungal activity of azoles
Sijin Hang +7 more
doaj +2 more sources
Regulation of ABC Transporters and Ergosterol Biosynthesis by the Transcription Factor FvADS-1 Controls Azole Resistance and Virulence in Fusarium verticillioides [PDF]
Journal of FungiFusarium verticillioides is a significant agricultural pathogen and an emerging causative agent of invasive fusariosis in clinical settings. Fusarium species frequently exhibit resistance to available antifungal agents, yet the molecular mechanisms ...
Yajing Yin +5 more
doaj +2 more sources
Therapeutic Tools for Vulvovaginal Candidiasis: Current and Emerging Antifungal Agents [PDF]
Journal of FungiVulvovaginal candidiasis (VVC) represents a widespread gynaecological challenge, affecting approximately 75% of women at some point during their reproductive years, with a significant subset progressing to recurrent forms (RVVC).
Guillermo Quindós +6 more
doaj +2 more sources
Vinylation of N-Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones
Molecules, 2023 A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and azoles in the presence of potassium hydroxide was developed. This reaction proceeded under mild and transition metal-free conditions through an addition/elimination cascade ...
Martina Palomba +5 more
doaj +1 more source
In Vitro and In Vivo Interactions of TOR Inhibitor AZD8055 and Azoles against Pathogenic Fungi
Microbiology Spectrum, 2022 In the present study, in vitro and in vivo interactions of TOR inhibitor AZD8055 and azoles, including itraconazole, voriconazole, posaconazole and fluconazole, against a variety of pathogenic fungi were investigated.
Yi Sun +5 more
doaj +1 more source