Results 31 to 40 of about 23,173 (263)
Nature Communications, 2020 Aryl azoles are common scaffolds in pharmaceutically relevant molecules. Here, the authors report the mild and highly regioselective ortho magnesiation of aryl azoles using a tailored magnesium amide base in hydrocarbon solvents followed by an efficient ...
Ferdinand H. Lutter +6 more
doaj +1 more source
Angewandte Chemie, EarlyView.While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond +7 more
wiley +2 more sources
Journal of Fungi, 2021 Numerous reports describe the emergence of resistance in dermatophytes, especially in T. rubrum and T. mentagrophytes/indotineae strains. We here present a review of the current status of resistance in dermatophytes worldwide.
Rosalie Sacheli, Marie-Pierre Hayette
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Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Journal of Fungi, 2021 Azoles are one of the most widely used drugs to treat fungal infections. To further understand the fungal response to azoles, we analyzed the MAPK circuitry of the model yeast Saccharomyces cerevisiae that operates under treatment with these antifungals.
Ángela Sellers-Moya +3 more
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Direct Arylation of Simple Azoles Catalyzed by 1,10-Phenanthroline Containing Palladium Complexes: An Investigation of C4 Arylation of Azoles and the Synthesis of Triarylated Azoles by Sequential Arylation [PDF]
, 2016 Direct triarylation and sequential triarylation reactions of simple azoles catalyzed by [Pd(phen)2]PF6 are described. Simple azoles, such as N-methylimidazole, thiazole, and oxazole, were observed to undergo triaryaltion reactions even at their C4 ...
Toshiaki Murai (1402201) +2 more
core +1 more source
Azole γ‐Peptides Helix Switching via Heterocycle Substitutions
Angewandte Chemie, EarlyView.Heterocycle substitution in azole‐based γ‐amino acids enables control over the helical shape of heterocyclic γ‐peptides. S↔N permutation in thiazole residues switches a canonical 9‐helix into a flexible helix exhibiting discontinuous hydrogen bonding.
Samantha Chaise +10 more
wiley +2 more sources
Determination of important azoles in soil solution using CE [PDF]
, 2019 The azoles (represented by penconazole, cyproconazole, and tebuconazole in this study) are frequently used agrochemicals to protect various crops against mildew and fungi.
Dytrtová, Jana Jaklová +3 more
core +1 more source
Challenges in Ramularia collo-cygni Control
Encyclopedia, 2022 Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, has recently become widespread in Europe. Succinate dehydrogenase inhibitor (SDHI) and demethylation inhibitor (DMI) fungicides are mainly applied for disease control on barley fields,
Andres Mäe, Riinu Kiiker
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Antifungal Drug Plasma Exposures: A Possible Contribution of Vitamin D-Related Gene Variants
Pharmaceuticals, 2022 Vitamin D (VD) seems to influence drug clearance and outcome. Antifungal drugs (AFU) are the most used azoles in clinical practice. In the literature, no data are available concerning VD’s impact on AFU therapy. The aim of this study was to analyze if VD
Jessica Cusato +12 more
doaj +1 more source