Results 31 to 40 of about 7,725 (230)
Formal Nucleophilic Substitution of Bromocyclopropanes with Azoles
, 2016 A highly diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with azoles is described. A wide range of azoles, including pyrroles, indoles, benzimidazoles, pyrazoles, and benzotriazoles, can be ...
Jack Xu (2096188) +3 more
core +2 more sources
Angewandte Chemie, EarlyView.The first nitrile reductive couplings beyond stoichiometric metals or metalloids are described. Using a ruthenium catalyst derived from RuHCl(CO)(PPh3)3 and Cy‐BIPHEP, 2‐propanol‐mediated reductive coupling of phenyl acrylate with aromatic or aliphatic nitriles delivers α,β‐unsaturated β‐amino esters.
Sebastian Höthker +3 more
wiley +2 more sources
Challenges in Ramularia collo-cygni Control
Encyclopedia, 2022 Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, has recently become widespread in Europe. Succinate dehydrogenase inhibitor (SDHI) and demethylation inhibitor (DMI) fungicides are mainly applied for disease control on barley fields,
Andres Mäe, Riinu Kiiker
doaj +1 more source
HaematologicaMobilized hematopoietic stem and progenitor cells (HSPCs) are essential for transplantationbased therapies, including curative gene therapies for sickle cell disease (SCD).
Brandon L. Vu +5 more
doaj +1 more source
Frontiers in Microbiology, 2013 Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, 7 upregulated and 4 downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa ...
Xianyun eSun +7 more
doaj +1 more source
Antifungal Drug Plasma Exposures: A Possible Contribution of Vitamin D-Related Gene Variants
Pharmaceuticals, 2022 Vitamin D (VD) seems to influence drug clearance and outcome. Antifungal drugs (AFU) are the most used azoles in clinical practice. In the literature, no data are available concerning VD’s impact on AFU therapy. The aim of this study was to analyze if VD
Jessica Cusato +12 more
doaj +1 more source
Azoles: Biological Activities and Synthetic Pathways
, 2023 With an increase in patients with suppressed immune system during the past few years, the danger of human fungal infections has significantly grown. There has been a rapid progress in the field of fungal infection treatment.
Amol K. Kharde, Vinod R. Kadu
core +1 more source
Trichosporon asahii Infective Endocarditis of Prosthetic Valve: A Case Report and Literature Review
Antibiotics, 2023 Trichosporon spp. endocarditis is a severe and hard-to-treat infection. Immunosuppressed subjects and carriers of prosthetic valves or intracardiac devices are at risk.
Alice Mulè +13 more
doaj +1 more source
European Journal of Clinical Microbiology & Infectious Diseases, 1997 Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W.; id_orcid 0000-0001-5626-2251 +2 more
openaire +4 more sources
New Antifungal Agents with Azole Moieties
Pharmaceuticals, 2022 Fungal conditions affect a multitude of people worldwide, leading to increased hospitalization and mortality rates, and the need for novel antifungals is emerging with the rise of resistance and immunocompromised patients.
Melissa Martins Teixeira +3 more
doaj +1 more source