Results 41 to 50 of about 23,173 (263)
N‑Trifluoropropylation of Azoles through N‑Vinylation and Sequential Hydrogenation [PDF]
, 2022 Installing a fluoroalkyl group onto the nitrogen atom of azoles represents a potential strategy for lead optimization in medicinal chemistry. Herein, we describe a method for the N-trifluoropropylation of azoles.
Guo-Shu Chen (8736579) +6 more
core +1 more source
HaematologicaMobilized hematopoietic stem and progenitor cells (HSPCs) are essential for transplantationbased therapies, including curative gene therapies for sickle cell disease (SCD).
Brandon L. Vu +5 more
doaj +1 more source
Frontiers in Microbiology, 2013 Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, 7 upregulated and 4 downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa ...
Xianyun eSun +7 more
doaj +1 more source
Trichosporon asahii Infective Endocarditis of Prosthetic Valve: A Case Report and Literature Review
Antibiotics, 2023 Trichosporon spp. endocarditis is a severe and hard-to-treat infection. Immunosuppressed subjects and carriers of prosthetic valves or intracardiac devices are at risk.
Alice Mulè +13 more
doaj +1 more source
European Journal of Clinical Microbiology & Infectious Diseases, 1997 Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W.; id_orcid 0000-0001-5626-2251 +2 more
openaire +4 more sources
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Eficacia de los azoles en el tratamiento de la leishmaniasis cutánea [PDF]
, 2016 Introduction: standard treatment of cutaneous leishmaniasis has many limitations associated with adverse effects, contraindications and high cost, for this reason have been explored other therapeutic options as the azole compounds.
Cardona Arias, Jaiberth Antonio +3 more
core +2 more sources
New Antifungal Agents with Azole Moieties
Pharmaceuticals, 2022 Fungal conditions affect a multitude of people worldwide, leading to increased hospitalization and mortality rates, and the need for novel antifungals is emerging with the rise of resistance and immunocompromised patients.
Melissa Martins Teixeira +3 more
doaj +1 more source
Efficient synthesis of 2-substituted azoles: radical C–H alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition [PDF]
, 2017 A simple and efficient synthesis of 2-substituted azoles by alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition has been developed.
Li-kun Jin, Chun Cai, Ze-lin Li
core +1 more source
Copper-Catalyzed N‑Arylation of Azoles and Mannich-Type Coupling of Ketones and Azoles under Metal-Free Conditions [PDF]
, 2016 A new process has been developed for the copper-catalyzed direct N-arylation of five-membered heterocycles with azoles. Five-membered heterocycles bearing an acetyl group also underwent a Mannich-type reaction with activated azoles to give the ...
Kai Sun (140584) +4 more
core +1 more source