Results 41 to 50 of about 34,899 (249)

Fungicidal activity plus reservoir effect allow short treatment courses with terbinafine in tinea pedis [PDF]

, 2008
Terbinafine, a synthetic allylamine, exerts fungicidal activity against dermatophytes, the causative pathogens of tinea pedis. As proven in numerous clinical trials, tinea pedis can be effectively and safely treated by topical terbinafine.
Korting, Hans Christian, Schäfer-Korting, Monika, Schöllmann, C.   +2 more
core   +1 more source

Azoles

, 2014
Capítulo cuarto del temario del segundo bloque de la asignatura Ampliación de Química Orgánica Avanzada. Azoles.
Raoul Herbrecht, Yasmine Nivoix
openaire   +3 more sources

Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against Candida albicans

Antibiotics
Background/Objectives: The diminished efficacy of azoles in treating fungal infections is attributed to the emergence of resistance among pathogenic fungi. Employing a synergistic approach with other compounds to enhance the antifungal activity of azoles
Sijin Hang, Li Wang, Zhe Ji, Xuqing Shen, Xinyu Fang, Wanqian Li, Yuanying Jiang, Hui Lu   +7 more
doaj   +1 more source

Sterol C-22 desaturase ERG5 mediates the sensitivity to antifungal azoles in Neurospora crassa and Fusarium verticillioides

Frontiers in Microbiology, 2013
Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, 7 upregulated and 4 downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa ...
Xianyun eSun, Wenzhao eWang, Kangji eWang, Xinxu eYu, Jie eLiu, Fucai eZhou, Baogui eXie, Shaojie eLi   +7 more
doaj   +1 more source

New Antifungal Agents with Azole Moieties

Pharmaceuticals, 2022
Fungal conditions affect a multitude of people worldwide, leading to increased hospitalization and mortality rates, and the need for novel antifungals is emerging with the rise of resistance and immunocompromised patients.
Melissa Martins Teixeira, Diogo Teixeira Carvalho, Emília Sousa, Eugénia Pinto   +3 more
doaj   +1 more source

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models [PDF]

, 2017
Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B. cenocepacia is extremely resistant towards antibiotics and therapy is complicated by its ability to form biofilms.
Brackman, Gilles, Cappoen, Davie, Coenye, Tom, Cos, Paul, Crabbé, Aurélie, Rigole, Petra, Van den Driessche, Freija, Vanhoutte, Bieke, Vercruysse, Jurgen, Verstraete, Glenn, Vervaet, Chris   +10 more
core   +4 more sources

Azole resistance inCandida

European Journal of Clinical Microbiology & Infectious Diseases, 1997
Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W., Baily, G.G., Hood, S.V.
openaire   +4 more sources

LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles

Frontiers in Microbiology, 2020
Lam proteins transport sterols between the membranes of different cellular compartments. In Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs.
Svyatoslav S. Sokolov, Margarita A. Vorobeva, Alexandra I. Smirnova, Alexandra I. Smirnova, Ekaterina A. Smirnova, Nataliya I. Trushina, Nataliya I. Trushina, Kseniia V. Galkina, Kseniia V. Galkina, Fedor F. Severin, Dmitry A. Knorre, Dmitry A. Knorre   +11 more
doaj   +1 more source

Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates. [PDF]

, 2012
The imidazoles 1a–g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = sN(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of
Ahrendt, Albery, Almaşi, Baidya, Brazier, Brotzel, Diner, Dominguez de Maria, Enders, Erkkilä, Grošelj, Herbert Mayr, Komisarska, Lakhdar, Lakhdar, Lelais, List, List, MacMillan, Mahiuddin Baidya, Marcus, Mayr, Mayr, Mayr, Mayr, Mayr, Sami Lakhdar, Schmid, Schmid, Schmid, Seayad, Seebach, Tsogoeva, Uria   +33 more
core   +1 more source

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal, Valera Vera, Edward Augusto   +4 more
core   +1 more source