Results 61 to 70 of about 34,899 (249)

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundCryptococcosis is a global invasive mycosis with high rates of morbidity and mortality, especially in AIDS patients. Its treatment remains challenging because of the limited antifungals and their unavoidable toxicity, and as such more efforts ...
Yali Li, Sheng Li, Min Chen, Jialing Xiao, Hong Fang   +4 more
doaj   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]

, 2019
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam, Alina Secrieru, Alkorta, Andes, Anwar, Behr, Brown, Castillo, Catalan, Chauhan, Clark, Elguero, Elnagdi, Favre, Fichez, Hall, Horta, Katritzky, Katritzky, Kost, Kumar, Larina, Maria Lurdes Santos Cristiano, Mert, Minkin, Minkin, Mohamed, Nagy, Nimbalkar, Paul Michael O’Neill, Schofield, Simons, Szajda, Taylor, Zerbi   +34 more
core   +2 more sources

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, EarlyView.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source

Development of cross-resistance by Aspergillus fumigatus to clinical azoles following exposure to prochloraz, an agricultural azole [PDF]

, 2014
Background: The purpose of this study was to unveil whether azole antifungals used in agriculture, similar to the clinical azoles used in humans, can evoke resistance among relevant human pathogens like Aspergillus fumigatus, an ubiquitous agent in ...
Estevinho, Leticia M., Faria-Ramos, Isabel, Farinha, Sofia, Miranda, Isabel M., Neves-Maia, João, Pina-Vaz, Cidália, Rodrigues, Acácio G., Tavares, Pedro R.   +7 more
core   +1 more source

Correlation Between the Molecular Structure of Metal‐Supporting Ligands and Catalysis in the Oxygenase‐Mimicking Immobilized Metal Complex Catalysts

European Journal of Inorganic Chemistry, EarlyView.
The correlation between the structures of metal complexes immobilized in the mesopores of hydrophobically modified silicate supports was examined in relation to the catalytic activities toward C‐H oxidation. On the alkene oxidation with H2O2, the iron catalyst bearing bis(imidazolyl)methane ligand promotes allylic oxidation, whereas the mononuclear ...
Yuta Akizawa, Hiroe Fukuzaki, Nana Aizawa, Sho Ikeda, Airi Kawabe, Saori Nishiyama, Iori Nagasawa, Masaya Okamura, Shiro Hikichi   +8 more
wiley   +1 more source

Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles

Beilstein Journal of Organic Chemistry, 2021
Desulfonylative alkylation of N-tosyl-1,2,3-triazoles under metal-free conditions leading to β-triazolylenones is reported here. The present study encompasses the synthesis of triazoles with a new substitution pattern in a single step from cyclic 1,3 ...
Soumyaranjan Pati, Renata G. Almeida, Eufrânio N. da Silva Júnior, Irishi N. N. Namboothiri   +3 more
doaj   +1 more source

Effect of azole fungicide mixtures, alternations and dose on azole sensitivity in the wheat pathogen Zymoseptoria tritici [PDF]

, 2016
The evolution of fungicide resistance in the cereal pathogen Zymoseptoria tritici, is a serious threat to the sustainability and profitability of wheat production in Europe. Application of azole fungicides has been shown to affect fitness of Z.
Bosch, Bosch, Bosch, Brown, Burke, Cools, Cools, Cools, Crawley, Fraaije, Fraaije, Fraaije, Fraaije, Green, Hobbelen, Hobbelen, Hobbelen, Hobbelen, Hollomon, Kendall, Kendall, Mavroeidi, Mavroeidi, Mikaberidze, Mullins, O'Sullivan, Rieu, Shaw, Shaw, Stammler, Stammler, Zadoks   +31 more
core   +1 more source

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, EarlyView.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source