Results 61 to 70 of about 23,046 (254)

Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundCryptococcosis is a global invasive mycosis with high rates of morbidity and mortality, especially in AIDS patients. Its treatment remains challenging because of the limited antifungals and their unavoidable toxicity, and as such more efforts ...
Yali Li, Sheng Li, Min Chen, Jialing Xiao, Hong Fang   +4 more
doaj   +1 more source

Direct Arylation of Simple Azoles Catalyzed by 1,10-Phenanthroline Containing Palladium Complexes: An Investigation of C4 Arylation of Azoles and the Synthesis of Triarylated Azoles by Sequential Arylation

, 2016
Direct triarylation and sequential triarylation reactions of simple azoles catalyzed by [Pd(phen)2]PF6 are described. Simple azoles, such as N-methylimidazole, thiazole, and oxazole, were observed to undergo triaryaltion reactions even at their C4 ...
Toshiaki Murai (1402201), Eiji Yamaguchi (1447486), Fumitoshi Shibahara (1490908)   +2 more
core   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, EarlyView.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source

N‑Trifluoropropylation of Azoles through N‑Vinylation and Sequential Hydrogenation

, 2022
Installing a fluoroalkyl group onto the nitrogen atom of azoles represents a potential strategy for lead optimization in medicinal chemistry. Herein, we describe a method for the N-trifluoropropylation of azoles.
Guo-Shu Chen (8736579), Yin-Yin Zhuang (14058943), Shu-Jie Chen (8736582), Jia-Hui Li (5981738), Yun-Lin Liu (2178446), Zhi-Qing He (11918849), Chang-Ping Chen (1849531)   +6 more
core   +1 more source

Correlation Between the Molecular Structure of Metal‐Supporting Ligands and Catalysis in the Oxygenase‐Mimicking Immobilized Metal Complex Catalysts

European Journal of Inorganic Chemistry, Volume 29, Issue 16, 4 June 2026.
The correlation between the structures of metal complexes immobilized in the mesopores of hydrophobically modified silicate supports was examined in relation to the catalytic activities toward C‐H oxidation. On the alkene oxidation with H2O2, the iron catalyst bearing bis(imidazolyl)methane ligand promotes allylic oxidation, whereas the mononuclear ...
Yuta Akizawa, Hiroe Fukuzaki, Nana Aizawa, Sho Ikeda, Airi Kawabe, Saori Nishiyama, Iori Nagasawa, Masaya Okamura, Shiro Hikichi   +8 more
wiley   +1 more source

Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles

Beilstein Journal of Organic Chemistry, 2021
Desulfonylative alkylation of N-tosyl-1,2,3-triazoles under metal-free conditions leading to β-triazolylenones is reported here. The present study encompasses the synthesis of triazoles with a new substitution pattern in a single step from cyclic 1,3 ...
Soumyaranjan Pati, Renata G. Almeida, Eufrânio N. da Silva Júnior, Irishi N. N. Namboothiri   +3 more
doaj   +1 more source

Eficacia de los azoles en el tratamiento de la leishmaniasis cutánea

, 2016
Introduction: standard treatment of cutaneous leishmaniasis has many limitations associated with adverse effects, contraindications and high cost, for this reason have been explored other therapeutic options as the azole compounds.
Cardona Arias, Jaiberth Antonio, Palacio Barco, MA, Palacio Barco, M.A, López Carvajal, Liliana   +3 more
core   +1 more source

Activation of Aryl Halides by Triplet–Triplet Annihilation Upconversion Enabling Coupling Processes Under an Open‐to‐Air Environment

European Journal of Organic Chemistry, EarlyView.
Triplet–triplet annihilation upconversion (TTA‐UC) performed inside supramolecular viscoelastic gels enables efficient CC and C–heteroatom coupling reactions under green LED irradiation in open‐air conditions. The gel network restricts oxygen diffusion, preserves triplet states, and allows aryl halide activation through upconverted excited states ...
Daniel Álvarez‐Gutiérrez, Paola Domínguez Domínguez, M. Consuelo Jiménez, David Díaz Díaz, Raúl Pérez‐Ruiz   +4 more
wiley   +1 more source

Susceptibility of Mexican isolates of yeasts and moulds to amphotericin B and triazole antifungals

Journal of Infection in Developing Countries, 2009
Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited.
José Luis Arredondo-García, Carlos F. Amábile-Cuevas, RedMic2 Study Group   +2 more
doaj   +1 more source