Results 61 to 70 of about 23,173 (263)

Visible-Light Photoredox-Catalyzed Coupling Reaction of Azoles with α‑Carbamoyl Sulfides [PDF]

, 2016
A simple, straightforward strategy for the synthesis of N-substituted azoles is reported that involves a visible-light photoredox-catalyzed coupling reaction of azoles with α-carbamoyl sulfides.
Lucie Jarrige (2821685), Guillaume Levitre (2821682), Géraldine Masson (1525453)   +2 more
core   +3 more sources

Development and Characterization of Ribes nigrum Extract‐Loaded PLGA/Chitosan Nanoparticles as a Vaginal Drug Delivery System for Vulvovaginal Candidiasis

Journal of Applied Polymer Science, EarlyView.
Ribes nigrum extract‐loaded PLGA/chitosan nanoparticles is developed as a vaginal drug delivery system for vulvovaginal candidiasis. The chitosan‐coated nanoparticles exhibit favorable physicochemical properties, strong mucoadhesion, sustained release for up to 2 weeks, excellent biocompatibility, and potent antifungal activity against Candida albicans,
Ayca Aslan Aras, Deniz Uygunoz, Emre Karaduman, Neslihan Merve Eren, Secil Gunay Avci, Mehmet Burcin Piskin, Emek Moroydor Derun   +6 more
wiley   +1 more source

In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. [PDF]

, 2015
Several azoles are widely used to treat human fungal infections. Increasing resistance to these azoles has prompted exploration of their synergistic antifungal activities when combined with other agents.
Grilley, Michelle, Shrestha, Sanjib K., Anderson, Thomas, Dhiman, Christine   +3 more
core   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Cooperative Phosphine-Photoredox Catalysis Enables N–H Activation of Azoles for Intermolecular Olefin Hydroamination [PDF]

Catalytic intermolecular olefin hydroamination is an enabling synthetic strategy that offers direct and atom-economical access to a variety of nitrogen-containing compounds from abundant feedstocks.
Abigail, Doyle, Kassandra, Sedillo, Flora, Fan, Robert, Knowles   +3 more
core   +1 more source

Susceptibility of Mexican isolates of yeasts and moulds to amphotericin B and triazole antifungals

Journal of Infection in Developing Countries, 2009
Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited.
José Luis Arredondo-García, Carlos F. Amábile-Cuevas, RedMic2 Study Group   +2 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Electrochemical N-olefination for the regio- and stereo-selective synthesis of vinyl azoles

Green Synthesis and Catalysis
A selenium-catalyzed electrosynthesis involving regio- and stereo-selective N-olefination of azoles was developed. The room-temperature reaction was efficient (up to 97 ​% yield) and compatible with various styrenes and azoles.
Kejun Lin, Jianyong Lan, Lin Hao, Tingshun Zhu   +3 more
doaj   +1 more source

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Iron-Catalyzed Direct α-Arylation of Ethers with Azoles [PDF]

, 2015
The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process.
Fiser, Béla, Correa Navarro, Arkaitz, Gómez Bengoa, Enrique, Gómez-Bengoa, Enrique   +3 more
core   +1 more source