Results 61 to 70 of about 7,725 (230)

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source

Farmacología de los azoles [PDF]

, 2007
Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake.
Azanza, J.R. (José Ramón), Sadaba, B. (Belén), Garcia-Quetglas, E. (Emilio)   +2 more
core   +1 more source

Molecular Modification Strategies for CO2 Electroreduction to C2+ Products: Classifications, Mechanisms, Advances, and Perspectives

EcoEnergy, EarlyView.
This review comprehensively outlines molecular modification strategies for steering CO2 electroreduction toward C2+ products, including the classification of diverse molecular structures, elucidation of their roles in microenvironment regulation, dissection of C–C coupling pathway engineering, and forward‐looking perspectives on machine learning and ...
Lingling Peng, Hanwen Liu, Tianyou Peng
wiley   +1 more source

Iron-Catalyzed Direct α-Arylation of Ethers with Azoles [PDF]

, 2015
The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process.
Fiser, Béla, Correa Navarro, Arkaitz, Gómez Bengoa, Enrique, Gómez-Bengoa, Enrique   +3 more
core   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

3D-QSAR and pharmacophore model study on aryl diphenolic azoles as estrogen receptor-b ligands

, 2013
3D-QSAR and pharmacophore model study on aryl diphenolic azoles as estrogen receptor-b ...
Jun-Zhi Wang, 邓伟侨, Hua-Jun Luo, Kun Zou, Nian-Yu Huang   +4 more
core  

Copper-Catalyzed N‑Arylation of Azoles and Mannich-Type Coupling of Ketones and Azoles under Metal-Free Conditions

, 2016
A new process has been developed for the copper-catalyzed direct N-arylation of five-membered heterocycles with azoles. Five-membered heterocycles bearing an acetyl group also underwent a Mannich-type reaction with activated azoles to give the ...
Kai Sun (140584), Lulu Liu (793645), Jingjing Sun (543035), Xin Wang (91924), Zhonghong Zhu (1402981)   +4 more
core   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species [PDF]

Jinqing Zhang,1,* Gaolian Li,2,* Jing Hu,3,* Jingwen Tan,4 Heng Zhang,5 Yizheng Zhou5 1Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Gynaecology ...
Li G, Zhang J, Hu J, Tan J, Zhang H, Zhou Y   +5 more
core  

Direct, Regioselective N‑Alkylation of 1,3-Azoles

, 2016
Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the
Alessandro A. Boezio (1447501), Russell F. Graceffa (1447498), Shuai Chen (506142)   +2 more
core   +1 more source