Disulfiram reverses fluconazole-resistance mediated by Cdr1 in Candida albicans and interferes with biofilm formation [PDF]
Applied Microbiology and BiotechnologyThe incidence of Candida albicans infections has risen markedly, particularly among immunocompromised individuals and cancer patients undergoing chemotherapy. Fluconazole is commonly used as a first-line treatment for C.
Ahmed Rezk +4 more
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Effect of fluconazole dose on the extent of fluconazole-triazolam interaction [PDF]
British Journal of Clinical Pharmacology, 1996 1Azole antimycotics interact with the short acting hypnotic triazolam. The effect of fluconazole dose on the extent of fluconazole‐triazolam interaction was investigated in a double‐blind, randomized cross‐over study of four phases. 2Eight healthy volunteers received either 50 mg, 100 mg or 200 mg (400 mg on day 1) of fluconazole or placebo orally ...
Klaus Olkkola, Pertti J. Neuvonen
exaly +4 more sources
Clinical correlates for fluconazole resistance in Candida bloodstream infections [PDF]
Frontiers in Public HealthBackgroundCandidemia poses a growing global health threat, with rising fluconazole resistance complicating clinical management. This study aimed to investigate the species distribution and fluconazole resistance profiles of Candida bloodstream infections
Zihuan Li +7 more
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Physiologically based pharmacokinetic modeling of fluconazole: interpretation of gender-dependent pharmacokinetics and cytochrome P450 inhibition [PDF]
Frontiers in PharmacologyThe accurate prediction of clinical drug–drug interactions (DDIs) in modeling analysis relies on the fraction of metabolism and transport of the substrate drugs and on the inhibitory potency and plasma exposure of index inhibitors.
Kazuya Ishida +3 more
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Mutations in
mBio, 2020 Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak +12 more
doaj +1 more source
Iranian Journal of Public Health, 2020 Background: Dermatophytosis is one of the most common fungal infections in humans. Antifungals such as fluconazole are effectively used for treating dermatophytosis; however, drug resistance was observed in many cases.
Najmossadat MUSAVI BAFRUI +2 more
doaj +1 more source
Fluconazole Failure in the Treatment of Coccidioidal Meningitis
Journal of Fungi, 2022 Introduction: Coccidioidal meningitis (CM) is the most lethal form of disseminated coccidioidomycosis. Current guidelines recommend fluconazole as initial therapy but there has been a paucity of data regarding failure of fluconazole and optimal ...
Simran Gupta +4 more
doaj +1 more source
Fixed drug eruption caused by fluconazole
Медицинский вестник Юга России, 2023 Objective: to characterize a group of patients with fixed drug erythema (FDE) caused by fluconazole to determine the sensitivity and specificity of the local provocative application test (LPAT) and to evaluate cross-allergenic reactivity with other ...
T. N. Myasnikova +3 more
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Indifferent effect of nonsteroidal anti-inflammatory drugs (NSAIDs) combined with fluconazole against multidrug-resistant Candida auris [PDF]
Current Medical Mycology, 2019 Background and Purpose: Emergence and development of antifungal drug resistance in Candida species constitute a serious concern. Candida auris as an emerging multidrug-resistant fungus is the most important public health threat with high levels of ...
Fatemeh Ahangarkani +10 more
doaj +1 more source
Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates: a systematic review and meta-analysis [PDF]
Clinical and Experimental Pediatrics, 2021 Background Evidence shows that fluconazole prophylaxis is an effective treatment against invasive fungal infections in preterm neonates, however, the most efficient schedule of fluconazole prophylaxis for the colonization and mortality of invasive ...
Mahmoud Robati Anaraki +2 more
doaj +1 more source