Results 1 to 10 of about 3,432 (131)

Pseudolaric Acid B Combats Drug-Resistant Candida albicans Infection via Dual-Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration. [PDF]

Microb Biotechnol
We propose a novel therapeutic approach against fungal infection: Pseudolaric acid B directly eradicates C. albicans via Erg11 inhibition and uniquely, restores vaginal microecological homeostasis by promoting probiotic lactobacilli, addressing both the pathogen and the dysbiotic environment.
Shao T, Zhang Y, Xue B, Chu W.
europepmc   +2 more sources

Azole Resistance in Candida parapsilosis From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis [PDF]

Mycoses
ABSTRACT Background Candida species are common causes of nosocomial infections. Candida parapsilosis has emerged as an important pathogen. Mortality rates associated with invasive C. parapsilosis infections range from 14.5% to 47%, with azole resistance estimated between 4% and 15%.
García‐Hernández M, Nuñez‐García L, Ortíz‐Álvarez J, Delaye‐Martínez M, Flores‐Huacuja M, Vazquez‐Olivares M, Espinosa‐Camacho L, Delgado‐Sapien G, Morales‐Espinosa M, Becerra‐Lobato N, Franco‐Cendejas R, Garza‐González E, Ostrosky‐Zeichner L, Chávez‐Heres T, Hernández‐Durán M, López‐Jácome L, Colín‐Castro C.   +16 more
europepmc   +2 more sources

Molecular Identification and Evaluation of Resistance to Antifungal Drugs in <i>Candida</i> Species Isolated From Diaper Rash of Neonates. [PDF]

Health Sci Rep
ABSTRACT Background Diaper dermatitis, also recognized as diaper rash, is one of the most frequent skin conditions in neonates. Materials and Methods A total of 100 babies participated in the study. Eligibility included neonates aged 5–28 days and full‐time diaper wearers.
Shirvani F, Fattahi M, Karimi A, Armin S, Fahimzad SA, Tabatabaei SR, Ghanaei RM, Fallah F, Firooz A, Tabatabaee S, Radfar M, Kalani D, Foroozan H, Galoogah AF, Tamimi P.   +14 more
europepmc   +2 more sources

Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression [PDF]

Antimicrobial Resistance & Infection Control, 2020
Abstract Objective This study analyzed the distribution and drug resistance of Candida tropicalis ( C. tropicalis ) and the relationship between ERG11 and UPC2 expression and resistance to azole antifungal agents. Methods C. tropicalis was cultured and identified by Sabouraud Agar Medium, CHROM Agar Candida and ATB tests (Bio-Mérieux, France)
Dan Wang, Na An, Yuwei Yang, Xianggui Yang, Yingzi Fan, Jiafu Feng   +5 more
openaire   +4 more sources

ERG11 Gene Variability and Azole Susceptibility in Malassezia pachydermatis

Mycopathologia, 2022
AbstractMalassezia pachydermatis is part of the normal skin microbiota of various animal species but under certain circumstances becomes an opportunistic pathogen producing otitis and dermatitis. Commonly these Malassezia diseases are effectively treated using azoles. However, some cases of treatment failure have been reported. Alterations in the ERG11
Leyna Díaz, Gemma Castellá, M. Rosa Bragulat, F. Javier Cabañes   +3 more
openaire   +3 more sources

ERG11 Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of ERG11 Expression, Ergosterol Content, and Membrane Permeability

Antimicrobial Agents and Chemotherapy, 2020
Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated.
Patricia Navarro-Rodríguez, Loida López-Fernández, Adela Martin-Vicente, Josep Guarro, Javier Capilla   +4 more
openaire   +3 more sources

Characterization ofProtothecaCYP51/ERG11 as a possible target for therapeutic drugs

Medical Mycology, 2021
AbstractPrototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis ...
Takahisa Watanabe, Tomohiro Ishikawa, Hirotaka Sato, Noriyuki Hirose, Lisa Nonaka, Kaori Matsumura, Akira Masubuchi, Kazuko Nishimura, Michiaki Masuda   +8 more
openaire   +2 more sources

Rapid detection of ERG11 polymorphism associated azole resistance in Candida tropicalis

PLOS ONE, 2021
Increasing reports of azole resistance inCandida tropicalis, highlight the development of rapid resistance detection techniques. Nonsynonymous mutations in the lanosterol C14 alpha-demethylase (ERG11) gene is one of the predominant mechanisms of azole resistance inC.tropicalis. We evaluated the tetra primer-amplification refractory mutation system-PCR (
Saikat Paul, Rajneesh Dadwal, Shreya Singh, Dipika Shaw, Arunaloke Chakrabarti, Shivaprakash M. Rudramurthy, Anup Ghosh   +6 more
openaire   +4 more sources

ERG11 and ABC2 Overexpression but Not ERG11 Gene Mutations Are Involved in the Development of Itraconazole Resistance in Candida Krusei

Blood, 2015
Abstract Background: Recent years, the incidence and mortality of fungal infection has been on the rise in the patients with hematologic malignancies. This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Juanxia Meng, Qi Deng, Tao Sui   +12 more
openaire   +1 more source

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis

Biomédica, 2023
Introduction. Drug resistance to azoles is a growing problem in the Candida genus.Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains.Materials and methods. Nineteen strains, with and without exposure to fluconazole, were selected for this study.
Ana Elisa Rojas, Leidy Yurany Cárdenas, María Camila García, Jorge Enrique Pérez   +3 more
openaire   +3 more sources