Results 1 to 10 of about 6,282 (163)

Decoding resistance in Diutina catenulata by validating clinically relevant Erg11/Fks1 mutations [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveTo verify the causal relationship between specific mutations in the ERG11 and FKS1 genes and antifungal drug resistance in clinical isolates of Diutina catenulata.MethodsRecombinant plasmids expressing mutant alleles of ERG11 (F126L, K143R) or ...
Wei Zhang, Wei Zhang, Wei Zhang, Na Wang, Xin-Fei Chen, Bao-Hua He, Meng Xiao, Ying-Chun Xu, Qi Li   +8 more
doaj   +2 more sources

Pseudolaric Acid B Combats Drug-Resistant Candida albicans Infection via Dual-Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration. [PDF]

Microb Biotechnol
We propose a novel therapeutic approach against fungal infection: Pseudolaric acid B directly eradicates C. albicans via Erg11 inhibition and uniquely, restores vaginal microecological homeostasis by promoting probiotic lactobacilli, addressing both the pathogen and the dysbiotic environment.
Shao T, Zhang Y, Xue B, Chu W.
europepmc   +2 more sources

Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections [PDF]

Journal of Biomedical Science
Objectives We aimed to analyze the genomic variations associated with high azole resistance in the C. albicans isolates of intensive care unit (ICU) patients with Candida bloodstream infections (BSIs) and those from oropharyngeal colonization in HIV ...
Ming-Horng Tsai, Chih-Hung Hsieh, I.-An Tsai, Ching-Min Chang, Ting-Wen Chen, Jen-Fu Hsu, Shih-Ming Chu, Hsuan-Rong Huang, Shao-Hung Wang, Jang-Jih Lu   +9 more
doaj   +2 more sources

Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates [PDF]

mBio
Fluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 ...
Brooke D. Esquivel, Amanda Santos, Jeffrey M. Rybak, Darian J. Santana, P. David Rogers, Theodore C. White   +5 more
doaj   +2 more sources

Dual inhibition of ERG11 and CDR2 in drug-resistant Candida albicans by Indian phytochemicals: a combined in silico–in vitro approach [PDF]

Frontiers in Pharmacology
Invasive candidiasis caused by drug-resistant Candida albicans is an escalating global health concern due to the declining efficacy of conventional antifungal therapies.
Akshay Kisan Mundhe, Reena Rajkumari
doaj   +2 more sources

Azole Resistance in Candida parapsilosis From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis [PDF]

Mycoses
ABSTRACT Background Candida species are common causes of nosocomial infections. Candida parapsilosis has emerged as an important pathogen. Mortality rates associated with invasive C. parapsilosis infections range from 14.5% to 47%, with azole resistance estimated between 4% and 15%.
García‐Hernández M, Nuñez‐García L, Ortíz‐Álvarez J, Delaye‐Martínez M, Flores‐Huacuja M, Vazquez‐Olivares M, Espinosa‐Camacho L, Delgado‐Sapien G, Morales‐Espinosa M, Becerra‐Lobato N, Franco‐Cendejas R, Garza‐González E, Ostrosky‐Zeichner L, Chávez‐Heres T, Hernández‐Durán M, López‐Jácome L, Colín‐Castro C.   +16 more
europepmc   +2 more sources

Fluconazole resistance among Candida species with special emphasis on ERG11 gene mutations among Candida tropicalis [PDF]

Frontiers in Fungal Biology
IntroductionCandidiasis, an opportunistic fungal infection, is increasingly caused by non-albicans Candida species that show reduced fluconazole susceptibility, mainly due to ERG11 overexpression.
Vidyavathi B. Chitharagi, Gowthami S., Mahadevaiah Neelambike Sumana, Morubagal Raghavendra Rao, Sowmya G. S., Yogeesh D. Maheshwarappa   +5 more
doaj   +2 more sources

Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities [PDF]

Nature Communications
Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11
Wanqian Li, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang   +5 more
doaj   +2 more sources

Molecular Identification and Evaluation of Resistance to Antifungal Drugs in <i>Candida</i> Species Isolated From Diaper Rash of Neonates. [PDF]

Health Sci Rep
ABSTRACT Background Diaper dermatitis, also recognized as diaper rash, is one of the most frequent skin conditions in neonates. Materials and Methods A total of 100 babies participated in the study. Eligibility included neonates aged 5–28 days and full‐time diaper wearers.
Shirvani F, Fattahi M, Karimi A, Armin S, Fahimzad SA, Tabatabaei SR, Ghanaei RM, Fallah F, Firooz A, Tabatabaee S, Radfar M, Kalani D, Foroozan H, Galoogah AF, Tamimi P.   +14 more
europepmc   +2 more sources

Emergence of Candida (Candidozyma) auris in Minas Gerais, Brazil: Genomic Surveillance to Guide Rapid Public Health Responses. [PDF]

Mycoses
ABSTRACT Background Candida (Candidozyma) auris is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare‐associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.
Tomé LMR, Camargo DRA, Bastos RW, Dos Santos SCF, Guimarães NR, Pedroso SHSP, de Souza da Silva PE, Góes-Neto A, de Assis Figueredo LJ, da Côrte Castro G, Rodrigues AMRN, Cruzeiro FRS, Dutra NAC, Moura JBP, de Carvalho Pereira G, Faria CD, Giovanetti M, de Melo Iani FC, Alcantara LCJ, Adelino TÉR.   +19 more
europepmc   +2 more sources