Decoding resistance in Diutina catenulata by validating clinically relevant Erg11/Fks1 mutations [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectiveTo verify the causal relationship between specific mutations in the ERG11 and FKS1 genes and antifungal drug resistance in clinical isolates of Diutina catenulata.MethodsRecombinant plasmids expressing mutant alleles of ERG11 (F126L, K143R) or ...
Wei Zhang +8 more
doaj +5 more sources
Microbiology Spectrum, 2021 Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M Rybak +2 more
exaly +5 more sources
Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates [PDF]
mBioFluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 ...
Brooke D. Esquivel +5 more
doaj +3 more sources
Phylogenetic and Structural Analysis of Miconazole Susceptibility in Malassezia pachydermatis Isolates From Dogs With Otitis Externa. [PDF]
Vet DermatolBackground: An increased number of dogs with unresolved yeast otitis externa (OE) after miconazole treatment was observed at a tertiary practice. Hypothesis/Objectives: To evaluate miconazole susceptibility in Malassezia pachydermatis isolates from canine OE.
Belcher CM +5 more
europepmc +2 more sources
Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections [PDF]
Journal of Biomedical ScienceObjectives We aimed to analyze the genomic variations associated with high azole resistance in the C. albicans isolates of intensive care unit (ICU) patients with Candida bloodstream infections (BSIs) and those from oropharyngeal colonization in HIV ...
Ming-Horng Tsai +9 more
doaj +2 more sources
Fluconazole resistance among Candida species with special emphasis on ERG11 gene mutations among Candida tropicalis [PDF]
Frontiers in Fungal BiologyIntroductionCandidiasis, an opportunistic fungal infection, is increasingly caused by non-albicans Candida species that show reduced fluconazole susceptibility, mainly due to ERG11 overexpression.
Vidyavathi B. Chitharagi +5 more
doaj +2 more sources
Dual inhibition of ERG11 and CDR2 in drug-resistant Candida albicans by Indian phytochemicals: a combined in silico–in vitro approach [PDF]
Frontiers in PharmacologyInvasive candidiasis caused by drug-resistant Candida albicans is an escalating global health concern due to the declining efficacy of conventional antifungal therapies.
Akshay Kisan Mundhe, Reena Rajkumari
doaj +2 more sources
Emerging Antifungal Resistance in Tropical Mycoses: A Genomic and Clinical Perspective From Endemic Zones. [PDF]
J R Soc N ZAntifungal resistance in tropical mycoses is an increasingly important component of the global antimicrobial resistance crisis, particularly in endemic regions where diagnostic capacity, therapeutic options, and surveillance systems are limited. This review synthesizes clinical, environmental, and genomic evidence on resistance in major endemic and ...
Miraloglu M.
europepmc +2 more sources
Engineering Yarrowia lipolytica for high-level ergosterol production [PDF]
Synthetic and Systems BiotechnologyErgosterol is the key precursor of steroid drug synthesis. In this experiment, we systematically modified the synthesis of ergosterol. Firstly, we identified key rate-limiting enzymes through systematic screening of the post-squalene pathway ...
Xinyu Liu +7 more
doaj +2 more sources
Сибирский онкологический журнал, 2022 Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova +6 more
doaj +1 more source