Results 41 to 50 of about 3,432 (131)

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species [PDF]

Memórias do Instituto Oswaldo Cruz, 2016
The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles.
Silva, Danielly Beraldo dos Santos, Rodrigues, Luana Mireli Carbonera, Almeida, Adriana Araújo de, Oliveira, Kelly Mari Pires de, Grisolia/, Alexéia Barufatti   +4 more
openaire   +4 more sources

First Report of Fluconazole‐Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Sarah Santos Gonçalves, Simone Bravim Maifrede, Eduardo Yäkel, Pedro Massaroni Peçanha, Francisco Ozório Bessa‐Neto, Rodrigo Cayô, Anderson Messias Rodrigues, Patricia Muñoz, Pilar Escribano, Jesús Guinea   +9 more
wiley   +1 more source

Universal PCR assays to detect Candida FKS and ERG11 mutations

International Journal of Infectious Diseases
Introduction: The emergence of antifungal resistance in Candida species presents significant challenges in managing infections, particularly among immunocompromised patients. This study aimed to develop rapid molecular assays for detecting mutations in the FKS genes across four clinically significant Candida species: Candida albicans, C.
Dr Yuk Yam Cheung, Mr. Zhi Hao ZHANG, Ms. Wing Yan CHAR, Mr. Tsun Hang FONG, Mr. Chun Yu LI   +4 more
openaire   +2 more sources

Biocide Response of Candida auris

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Candida auris is an emerging multidrug‐resistant yeast demonstrating remarkable persistence in healthcare environments, contributing to nosocomial transmission and outbreak persistence. Increasing disinfectant failure reports have raised concerns regarding infection control policies, as environmental reservoirs play central roles in its spread.
Sidre Erganis, Ali Ozturk, Elif Ayca Sahin, Ayse Kalkanci   +3 more
wiley   +1 more source

Biotrophic Interactions Between a Mycoparasitic Ampelomyces Fungus and Podosphaera xanthii on Fungicide‐Treated Melon Leaves

Plant Pathology, Volume 75, Issue 2, March/April 2026.
The digital micrographs show images of the infection progress by the mycoparasitic Ampelomyces strain in a melon powdery mildew fungus Podosphaera xanthii that was treated with kresoxim‐methyl and sprayed with Ampelomyces spores under the high‐humidity conditions of a growth chamber.
Yuito Sato, Haruna Ikoma, Márk Z. Németh, Risa Tsumura, Diána Seress, Levente Kiss, Teruo Nonomura   +6 more
wiley   +1 more source

Yeast‐Based Biotechnology for Civilian Security

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Yeasts constitute robust and versatile eukaryotic platforms for biotechnological applications relevant to civilian security. Both native and genetically engineered yeast systems enable sensitive detection of chemical and biological hazards, effective removal of metals and organic pollutants, and detoxification of mycotoxins.
Justyna Ruchała, Roksolana Vasylyshyn, Maciej Wnuk   +2 more
wiley   +1 more source

[Investigation of ERG11 and MRR1 Resistance Genes in Candida parapsilosis Isolates].

Mikrobiyoloji bulteni
Candida parapsilosis is an important fungal pathogen that is particularly isolated from blood cultures. In recent years, although there are regional differences between centres, resistance to fluconazole which is the most commonly preferred drug for candidemia, has increased in many regions.
Kurt, Ozge, Kuskucu, Mert Ahmet, Yazgan, Zeynep, Arslan, Nese, Aygun, Gokhan, Kucukbasmaci, Omer   +5 more
openaire   +2 more sources

Harnessing Machine Learning to Uncover Hidden Patterns in Azole-Resistant CYP51/ERG11 Proteins

Microorganisms
Fungal resistance is a public health concern due to the limited availability of antifungal resources and the complexities associated with treating persistent fungal infections. Azoles are thus far the primary line of defense against fungi. Specifically, azoles inhibit the conversion of lanosterol to ergosterol, producing defective sterols and impairing
Otávio Guilherme Gonçalves de Almeida, Marcia Regina von Zeska Kress   +1 more
openaire   +3 more sources

Urosepsis by multidrug-resistant <i>Nakaseomyces glabratus</i> with non-functional Erg3 and Erg11-do collateral sensitivity and a unique mode of action make nitroxoline a viable UTI antifungal? [PDF]

mBio
Carolus H, Biriukov V, Vreys J, Lobo Romero C, Herrera Avila JP, Vergauwen R, Sofras D, Nysten J, Vanreppelen G, Vinken L, Britto Xavier B, Gabaldón T, Lagrou K, Naesens R, Van Dijck P.   +14 more
europepmc   +1 more source

Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts. [PDF]

PLoS Genet
Harrison MC, Rinker DC, LaBella AL, Opulente DA, Wolters JF, Zhou X, Shen XX, Groenewald M, Hittinger CT, Rokas A.   +9 more
europepmc   +1 more source