Results 41 to 50 of about 4,848 (182)
Blood, 2015 Abstract Background: Recent years, the incidence and mortality of fungal infection has been on the rise in the patients with hematologic malignancies. This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.
Xiaoyuan He +12 more
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, 2023 Background: The basidiomycete fungus, Ganoderma boninense is the main contributor to oil palm Basal Stem Rot (BSR) in Malaysia and Indonesia. Lanosterol 14α-Demethylase (ERG11) is a key enzyme involved in biosynthesis of ergosterol, which is an important
Vadamalai, Ganesan +6 more
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BMC Infectious Diseases, 2022 Background Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance to azoles, first-line antifungals has increased.
Essi Etonam Dovo +13 more
doaj +1 more source
ERG11 couples oxidative stress adaptation, hyphal elongation and virulence in Candida albicans [PDF]
FEMS Yeast Research, 2018 Candida albicans is a major fungal opportunistic pathogen for humans. In the treatment of C. albicans, azole drugs target the sterol 14α-demethylase (CYP51) encoded by ERG11 gene. Most studies have focused on the fact that the ERG11 mutant results in drug resistance, but its mechanism of action as a drug target has not been described yet.
YongQin, Wu +5 more
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Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis.
PLoS ONE, 2022 This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant and 10 azole-susceptible (S) clinical isolates of C.
Saikat Paul +6 more
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Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates
Molecular Biology Reports, 2022 Abstract Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance ...
Majid Zare-Bidaki +3 more
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Journal of Fungi, 2022 In recent decades, an epidemiological shift has been observed from Candida infections to non-albicans species and resistance to azoles. We investigated the associated factors and molecular mechanisms of azole-resistant blood isolates of C.
Teera Leepattarakit +2 more
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Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT In Candida albicans , the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in ...
Stephanie A, Flowers +4 more
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Infection and Drug Resistance, 2022 Arome Solomon Odiba,1,2 Olanrewaju Ayodeji Durojaye,3– 5 Ifeoma Maureen Ezeonu,6 Anthony Christian Mgbeahuruike,7 Bennett Chima Nwanguma1,2 1Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, 410001 ...
Odiba AS +4 more
doaj
Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion [PDF]
Antimicrobial Agents and Chemotherapy, 1996 The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase.
V L, Kan, A, Geber, J E, Bennett
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