Results 41 to 50 of about 3,777 (166)

Characterization of ERG11 Gene in Drug-Resistant Candida Albicans Isolated from Iranian Cases of Recurrent Vulvovaginal Candidiasis [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2020
Background & Aims:  Candida albicans is the most common fungal pathogen of human infections. C. albicans is responsible for significant mucosal infections such as vulvovaginitis in women.
Kambiz Diba, Shahram Khademvatan, Kowsar Jaafari, Soudabe Abharian   +3 more
doaj  

P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates

Medical Mycology, 2022
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM   Objective To determine the profile of fluconazole-resistant Candida isolates (FRCS) and the proportion of erg11 gene mutation in fluconazole-resistant C.
M.S., Sheena, Singh, Rakesh
openaire   +1 more source

The combined action of ERG11 gene overexpression and its mutations in the development of Candida albicans resistance to triazolic antifungals

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Vitaly V. Zverev, Alexander D. Voropaev, Maxim S. Afanasiev, Elena A. Voropaeva, Elena V. Budanova, Ludmila M. Smirnova, Sofia A. Anisova, Yulia N. Urban   +9 more
doaj   +1 more source

Biochemical research elucidating metabolic pathways in Pneumocystis*

Parasite, 2010
Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of ...
Kaneshiro E.S.
doaj   +1 more source

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa [PDF]

Genetics and Molecular Biology, 2014
The phytopathogenic fungus Moniliophthora perniciosa (Stahel) Aime & Philips-Mora, causal agent of witches' broom disease of cocoa, causes countless damage to cocoa production in Brazil.
Geruza de Oliveira Ceita, Laurival Antônio Vilas-Boas, Marcelo Santos Castilho, Marcelo Falsarella Carazzolle, Carlos Priminho Pirovani, Alessandra Selbach-Schnadelbach, Karina Peres Gramacho, Pablo Ivan Pereira Ramos, Luciana Veiga Barbosa, Gonçalo Amarante Guimarães Pereira, Aristóteles Góes-Neto   +10 more
doaj   +3 more sources

A Crucial Role for Ergosterol in Plasma Membrane Composition, Localisation, and Activity of Cdr1p and H⁺-ATPase in Candida albicans

Microorganisms, 2019
Candida albicans is an opportunistic fungal pathogen of humans. Treatment of C. albicans infections relies on azoles, which target the lanosterol 14α-demethylase (Erg11p) encoded by the ERG11 gene.
Jakub Suchodolski, Jakub Muraszko, Przemysław Bernat, Anna Krasowska   +3 more
doaj   +1 more source

Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from a North India region

Journal of Global Antimicrobial Resistance, 2020
Introduction: Fluconazole resistance in Candida tropicalis health care–associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. Materials and methods: A total
Nidhi Pandey, Muktanand Tripathi, Munesh K. Gupta, Ragini Tilak   +3 more
doaj   +1 more source

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source

Determining frequencies of fungicide resistance in Leptosphaeria maculans that render demethylation inhibitor fungicides ineffective in the field

Pest Management Science, EarlyView.
As little as 1–10% of the population is needed to be resistant for demethylation inhibitor fungicides to be rendered ineffective. Following a single round of selection, the frequency increases by more than 15% with limited fitness penalty detected when no selection is present.
Alec J McCallum, Alexander Idnurm, Stephen J Marcroft, Andrew H Ware, Elizabeth M Sheedy, Angela P Van de Wouw   +5 more
wiley   +1 more source

Azole Resistance in Cryptococcus gattii from the Pacific Northwest: Investigation of the Role of ERG11 [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT Cryptococcus gattii is responsible for an expanding epidemic of serious infections in Western Canada and the Northwestern United States (Pacific Northwest). Some patients with these infections respond poorly to azole antifungals, and high azole MICs have been reported in Pacific Northwest C ...
Charles E, Gast, Luiz R, Basso, Igor, Bruzual, Brian, Wong   +3 more
openaire   +2 more sources