Results 41 to 50 of about 6,332 (203)
Journal of Fungi, 2022 In recent decades, an epidemiological shift has been observed from Candida infections to non-albicans species and resistance to azoles. We investigated the associated factors and molecular mechanisms of azole-resistant blood isolates of C.
Teera Leepattarakit +2 more
doaj +1 more source
Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]
, 2019 Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni +6 more
core +2 more sources
Blood, 2015 Abstract Background: Recent years, the incidence and mortality of fungal infection has been on the rise in the patients with hematologic malignancies. This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.
Xiaoyuan He +12 more
openaire +1 more source
Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]
, 2018 We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T +10 more
core +3 more sources
Detection of ERG11 point mutations in Iranian fluconazoleresistant Candida albicans isolates
Current Medical Mycology, 2019 Background and Purpose: Candidiasis is referred to a group of superficial anddeep-tissue fungal infections often caused by Candida albicans. The superficialinfections affect the oral, oropharynx, esophagus, and vaginal mucosa. The treatmentof choice for these infections is the use of azoles, such as fluconazole.
Ali Sardari +2 more
openaire +3 more sources
Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]
, 2019 The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core +2 more sources
P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates
Medical Mycology, 2022 Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objective To determine the profile of fluconazole-resistant Candida isolates (FRCS) and the proportion of erg11 gene mutation in fluconazole-resistant C.
M.S., Sheena, Singh, Rakesh
openaire +1 more source
Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrata [PDF]
, 2021 AbstractAzoles, the most commonly used antifungal drugs, specifically inhibit the fungal lanosterol α-14 demethylase enzyme, which is referred to as Erg11. Inhibition of Erg11 ultimately leads to a reduction in ergosterol production, an essential fungal membrane sterol.
Bao Gia Vu, W. Scott Moye-Rowley
openaire +1 more source
Analysis of ergosterol and gene expression profiles of sterol ∆5,6-desaturase (ERG3) and lanosterol 14α-demethylase (ERG11) in Candida albicans treated with carvacrol [PDF]
, 2018 Introduction: Usually, for treatment of fungal infections, antifungals such as azoles are used, but one of the biggest problems faced in clinical practice is the emergence of resistance for most of these drugs.
Alizadeh, Fahimeh. +3 more
core +2 more sources
Journal of Fungi, 2022 Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformansERG11 gene (CYP51) has been observed in ...
Priscilla Belbir Atim +6 more
doaj +1 more source