Results 21 to 30 of about 3,777 (166)

Spectrum and functional properties of ERG11 gene mutations in fluconazole-resistant Candida albicans strains isolated from HIV-infected patients

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Rationale. The low efficacy of azole antimycotics in treatment of Candida infections, especially in HIV-infected patients, is often associated with overexpression of the ERG11 gene in Candida spp., which results in increased production of ergosterol the
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Alexander D. Voropaev, Yulia N. Urban, Mariam E. Suleimanova, Maxim S. Afanasiev, Elena V. Budanova, Elena A. Voropaeva   +7 more
doaj   +1 more source

The A756T Mutation of the ERG11 Gene Associated With Resistance to Itraconazole in Candida Krusei Isolated From Mycotic Mastitis of Cows

Frontiers in Veterinary Science, 2021
Candida krusei (C. krusei) has been recently recognized as an important pathogen involved in mycotic mastitis of cows. The phenotypic and molecular characteristics of 15 C.
Jun Du, Jun Du, Wenshuang Ma, Wenshuang Ma, Jiaqi Fan, Jiaqi Fan, Xiaoming Liu, Xiaoming Liu, Yujiong Wang, Yujiong Wang, Xuezhang Zhou, Xuezhang Zhou   +11 more
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CDR1, CDR2, MDR1 and ERG11 expression in azole resistant Сandida albicans isolated from HIV-infected patients in city of Moscow

Инфекция и иммунитет, 2022
Candida fungi are common opportunistic microorganisms capable of causing infections of various localization, as well as life-threatening conditions in immunocompromised patients, such as HIV-infected individuals, oncology patients, subjects undergoing ...
A. D. Voropaev, D. A. Yekaterinchev, Y. N. Urban, V. V. Zverev, Yu. V. Nesvizhsky, E. A. Voropaeva, E. I. Likhanskaya, M. S. Afanasiev, S. S. Afanasiev   +8 more
doaj   +1 more source

ERG11 Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of ERG11 Expression, Ergosterol Content, and Membrane Permeability

Antimicrobial Agents and Chemotherapy, 2020
Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated.
Patricia Navarro-Rodríguez, Loida López-Fernández, Adela Martin-Vicente, Josep Guarro, Javier Capilla   +4 more
openaire   +3 more sources

Characterization ofProtothecaCYP51/ERG11 as a possible target for therapeutic drugs

Medical Mycology, 2021
AbstractPrototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis ...
Takahisa Watanabe, Tomohiro Ishikawa, Hirotaka Sato, Noriyuki Hirose, Lisa Nonaka, Kaori Matsumura, Akira Masubuchi, Kazuko Nishimura, Michiaki Masuda   +8 more
openaire   +2 more sources

Screening of fluconazole resistance-related genes in Trichosporon asahii with induced fluconazole resistance in vitro

Di-san junyi daxue xuebao, 2020
Objective To screen the genes associated with fluconazole resistance in Trichosporon asahii to facilitate mechanistic studies of fluconazole resistance and the development of new antifungal agents. Methods Three clinical isolates of fluconazole-sensitive
XIA Zhikuan1, XIA Zhikuan1, GUO Jing, ZHANG Dequan, LU Yong, AO Junhong, YANG Rongya   +6 more
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Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei. [PDF]

PLoS ONE, 2015
To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei.The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and ...
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Yuchen Zhang, Juanxia Meng, Qi Deng, Tao Sui   +13 more
doaj   +1 more source

ERG11 and ABC2 Overexpression but Not ERG11 Gene Mutations Are Involved in the Development of Itraconazole Resistance in Candida Krusei

Blood, 2015
Abstract Background: Recent years, the incidence and mortality of fungal infection has been on the rise in the patients with hematologic malignancies. This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Juanxia Meng, Qi Deng, Tao Sui   +12 more
openaire   +1 more source

Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]

Current Medical Mycology
Background and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege, Şükrü Öksüz, Emel Akbaş, Emel Çalişkan, Mehmet Sungur   +4 more
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First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso

BMC Infectious Diseases, 2022
Background Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance to azoles, first-line antifungals has increased.
Essi Etonam Dovo, Théodora Mahoukèdè Zohoncon, Sessi Frida Tovo, Serge Théophile Soubeiga, Isabelle Touwendpoulimdé Kiendrebeogo, Albert Théophane Yonli, Rogomenona Alice Ouedraogo, Amana Mètuor Dabire, Florencia Wendkuuni Djigma, Christelle Wendyam Nadembega, Marius Belemgnegre, Paul Ouedraogo, Dorcas Obiri-Yeboah, Jacques Simpore   +13 more
doaj   +1 more source