Characterization of ERG11 Gene in Drug-Resistant Candida Albicans Isolated from Iranian Cases of Recurrent Vulvovaginal Candidiasis [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2020 Background & Aims: Candida albicans is the most common fungal pathogen of human infections. C. albicans is responsible for significant mucosal infections such as vulvovaginitis in women.
Kambiz Diba +3 more
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Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]
Current Medical MycologyBackground and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege +4 more
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ERG11 mutations associated with azole resistance in Candida albicans isolates from vulvovaginal candidosis patients [PDF]
Asian Pacific Journal of Tropical Biomedicine, 2015 Objective: To investigate the azole susceptibility of Candida albicans (C. albicans) from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole resistance. Methods: Three hundred and two
Bin Wang +8 more
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Lack of Association between Fluconazole Susceptibility and ERG11 Nucleotide Polymorphisms in Cryptococcus neoformans Clinical Isolates from Uganda [PDF]
Journal of Fungi, 2022 Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformansERG11 gene (CYP51) has been observed in ...
Priscilla Belbir Atim +6 more
doaj +2 more sources
Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida auris
Antimicrobial Agents and Chemotherapy, 2021 Candida auris is a novel Candida species that has spread in all continents, causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant to
Jizhou Li +5 more
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Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa [PDF]
Genetics and Molecular Biology, 2014 The phytopathogenic fungus Moniliophthora perniciosa (Stahel) Aime & Philips-Mora, causal agent of witches' broom disease of cocoa, causes countless damage to cocoa production in Brazil.
Geruza de Oliveira Ceita +10 more
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Variation in the erg11 Gene from Pneumocystis jirovecii.
, 2010 The erg11 gene codes for sterol 14-demethylase (14DM), a key enzyme in sterol biosynthesis and the target for triazole antimycotic drugs. Two sterol composition phenotypes have been described in patients with pneumonia caused by P. jirovecii; one phenotype has a much higher amount of lanosterol derivatives (C31 and C32 sterols) dominated by ...
SCOTT P. KEELY +6 more
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mSphereThe widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism.
Pengju Yu +7 more
doaj +2 more sources
Correlation between ERG11 Gene Mutations and Fluconazole Resistance in Candida albicans Strains Isolated from Rasht in Years 2015-2016 [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017 Background: Candida albicans as an opportunistic fungal pathogen in human causes candidiasis. The widespread use of azoles has led to the increase of azole resistance in Candida albicans isolates.
Saeedeh Balabandi +2 more
doaj +1 more source
Mycopathologia, 2014 The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Jingwen, Tan +6 more
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