Results 31 to 40 of about 3,777 (166)
Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis.
PLoS ONE, 2022 This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant and 10 azole-susceptible (S) clinical isolates of C.
Saikat Paul +6 more
doaj +1 more source
Journal of Fungi, 2022 In recent decades, an epidemiological shift has been observed from Candida infections to non-albicans species and resistance to azoles. We investigated the associated factors and molecular mechanisms of azole-resistant blood isolates of C.
Teera Leepattarakit +2 more
doaj +1 more source
Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT In Candida albicans , the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in ...
Stephanie A, Flowers +4 more
openaire +2 more sources
ERG11 couples oxidative stress adaptation, hyphal elongation and virulence in Candida albicans [PDF]
FEMS Yeast Research, 2018 Candida albicans is a major fungal opportunistic pathogen for humans. In the treatment of C. albicans, azole drugs target the sterol 14α-demethylase (CYP51) encoded by ERG11 gene. Most studies have focused on the fact that the ERG11 mutant results in drug resistance, but its mechanism of action as a drug target has not been described yet.
YongQin, Wu +5 more
openaire +2 more sources
Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion [PDF]
Antimicrobial Agents and Chemotherapy, 1996 The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase.
V L, Kan, A, Geber, J E, Bennett
openaire +2 more sources
Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates
Molecular Biology Reports, 2022 Abstract Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance ...
Majid Zare-Bidaki +3 more
openaire +2 more sources
Journal of Fungi, 2022 Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformansERG11 gene (CYP51) has been observed in ...
Priscilla Belbir Atim +6 more
doaj +1 more source
Detection of ERG11 point mutations in Iranian fluconazoleresistant Candida albicans isolates
Current Medical Mycology, 2019 Background and Purpose: Candidiasis is referred to a group of superficial anddeep-tissue fungal infections often caused by Candida albicans. The superficialinfections affect the oral, oropharynx, esophagus, and vaginal mucosa. The treatmentof choice for these infections is the use of azoles, such as fluconazole.
Ali Sardari +2 more
openaire +3 more sources
Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis [PDF]
Iranian Biomedical Journal, 2017 Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms.The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined.
Lotfali, Ensieh +7 more
openaire +2 more sources
Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida auris
Antimicrobial Agents and Chemotherapy, 2021 Candida auris is a novel Candida species that has spread in all continents, causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant to
Jizhou Li +5 more
openaire +3 more sources