Results 31 to 40 of about 3,432 (131)
Mycoses, Volume 69, Issue 5, May 2026.ABSTRACT Background The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. Methods Fourteen azole resistant Candida glabrata clinical isolates were collected from a Lebanese hospital and analysed through whole genome sequencing for ...
Christy Chedraoui +9 more
wiley +1 more source
Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates [PDF]
SpringerPlus, 2014 Correlating antifungal Azole drug resistance and mis-sense mutations of ERG11 has been paradoxical in pathogenic yeast Candida albicans. Amino acid substitutions (single or multiple) are frequent on ERG11, a membrane bound enzyme of Ergosterol biosynthesis pathway. Presence or absence of mutations can not sufficiently predict susceptibility. To analyze
Debnath, Surajit, Addya, Soma
openaire +2 more sources
Exploration, Volume 6, Issue 2, April 2026.We designed and synthesized a dual‐type AIE photosensitizer (named TB) spray, containing a cationic quaternary ammonium unit and a glycosyl‐targeted boronic acid moiety, characterized for the elimination of biofilm infections of Candidozyma auris (C. auris) on high‐touch surfaces.
Xiaoyu Xu +16 more
wiley +1 more source
Role of ERG11 and MDR1 genes in cycloheximide and multidrug resistance in Candida species
Brazilian Journal of MicrobiologyCandida species are amongst the commensals of the mucosal surfaces of the human body which include the oral cavity, vagina, and intestinal mucosa. Fungal infections are on the rise worldwide. The overall burden of infections due to fungi is difficult to estimate because the majority of them remain undiagnosed.
Zill-e- Huma +5 more
openaire +2 more sources
In Vitro and In Vivo Effects of 14α-Demethylase ( ERG11 ) Depletion in Candida glabrata [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT Sterol 14α-demethylase ( ERG11 ) is the target enzyme of azole antifungals that are widely used for the treatment of fungal infections. Candida glabrata is known to be less susceptible to fluconazole than most Candida albicans strains, and the ...
H, Nakayama +3 more
openaire +2 more sources
Infection and Drug Resistance, 2022 Resistance to antifungal drugs for treating Candida infections remains a major concern globally despite the range of medications available. Most of these drugs target key proteins essential to the life cycle of the organism. An enzyme essential for fungal cell membrane integrity, lanosterol 14-α demethylase (CYP51), is encoded by the ERG11 gene in ...
Arome Solomon Odiba +4 more
openaire +3 more sources
The Epidemiology and Infection Control of Candida Auris in Shanghai
Mycoses, Volume 69, Issue 4, April 2026.ABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Mingjing Wei +8 more
wiley +1 more source
ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection [PDF]
International Journal of Oral Science, 2018 AbstractThe hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form ...
Zhou, Yujie +10 more
openaire +2 more sources
iMetaMed, Volume 2, Issue 1, March 2026.Oral microbiota: findings, classification, clinical significance, and therapeutic interventions for human systemic diseases ABSTRACT The oral microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms that colonizes the oral cavity.
Miao Zhang +13 more
wiley +1 more source
Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations [PDF]
Journal of Antimicrobial Chemotherapy, 2008 To investigate fluconazole susceptibility of Candida albicans from non-AIDS patients and to analyse the relationship between mutations in the ERG11 gene of these isolates and fluconazole resistance.Four hundred and twenty-six clinical isolates of Candida species were collected. Fluconazole susceptibility was tested in vitro using microdilution and disc
Yonghao, Xu, Lamei, Chen, Chunyang, Li
openaire +2 more sources