Results 31 to 40 of about 4,848 (182)

Fluconazole susceptibility and ERG11 gene expression in vaginal candida species isolated from Lagos Nigeria

, 2012
Fluconazole resistance is an important type of resistance in Candida because in most countries, fluconazole is the drug of choice for vulvovaginal candidiasis. Candida species resist fluconazole by various mechanisms but there is paucity of data on these
Ogunsola, Folasade T, Fowora, Muinah A, Pam, Victoria K, Akpan, Juliet U, Oduyebo, Oyinlola O, Nwaokorie, Francisca O, Oladele, Rita O, Smith, Stella I   +7 more
core   +11 more sources

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BMC Infectious Diseases, 2018
Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen, Hui Wang   +6 more
doaj   +2 more sources

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans

Current Medical Mycology, 2017
Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades.
Fahimeh Alizadeh, Alireza Khodavandi, Sara Zalakian   +2 more
doaj   +1 more source

Spectrum and functional properties of ERG11 gene mutations in fluconazole-resistant Candida albicans strains isolated from HIV-infected patients

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Rationale. The low efficacy of azole antimycotics in treatment of Candida infections, especially in HIV-infected patients, is often associated with overexpression of the ERG11 gene in Candida spp., which results in increased production of ergosterol the
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Alexander D. Voropaev, Yulia N. Urban, Mariam E. Suleimanova, Maxim S. Afanasiev, Elena V. Budanova, Elena A. Voropaeva   +7 more
doaj   +1 more source

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients [PDF]

Current Medical Mycology, 2019
Background and Purpose: Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration.
Sony Paul, Iyanar Kannan, Kalyani Mohanram   +2 more
doaj   +1 more source

The A756T Mutation of the ERG11 Gene Associated With Resistance to Itraconazole in Candida Krusei Isolated From Mycotic Mastitis of Cows

Frontiers in Veterinary Science, 2021
Candida krusei (C. krusei) has been recently recognized as an important pathogen involved in mycotic mastitis of cows. The phenotypic and molecular characteristics of 15 C.
Jun Du, Jun Du, Wenshuang Ma, Wenshuang Ma, Jiaqi Fan, Jiaqi Fan, Xiaoming Liu, Xiaoming Liu, Yujiong Wang, Yujiong Wang, Xuezhang Zhou, Xuezhang Zhou   +11 more
doaj   +1 more source

CDR1, CDR2, MDR1 and ERG11 expression in azole resistant Сandida albicans isolated from HIV-infected patients in city of Moscow

Инфекция и иммунитет, 2022
Candida fungi are common opportunistic microorganisms capable of causing infections of various localization, as well as life-threatening conditions in immunocompromised patients, such as HIV-infected individuals, oncology patients, subjects undergoing ...
A. D. Voropaev, D. A. Yekaterinchev, Y. N. Urban, V. V. Zverev, Yu. V. Nesvizhsky, E. A. Voropaeva, E. I. Likhanskaya, M. S. Afanasiev, S. S. Afanasiev   +8 more
doaj   +1 more source

ERG11 Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of ERG11 Expression, Ergosterol Content, and Membrane Permeability

Antimicrobial Agents and Chemotherapy, 2020
Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated.
Patricia Navarro-Rodríguez, Loida López-Fernández, Adela Martin-Vicente, Josep Guarro, Javier Capilla   +4 more
openaire   +3 more sources

Screening of fluconazole resistance-related genes in Trichosporon asahii with induced fluconazole resistance in vitro

Di-san junyi daxue xuebao, 2020
Objective To screen the genes associated with fluconazole resistance in Trichosporon asahii to facilitate mechanistic studies of fluconazole resistance and the development of new antifungal agents. Methods Three clinical isolates of fluconazole-sensitive
XIA Zhikuan1, XIA Zhikuan1, GUO Jing, ZHANG Dequan, LU Yong, AO Junhong, YANG Rongya   +6 more
doaj   +1 more source

Characterization ofProtothecaCYP51/ERG11 as a possible target for therapeutic drugs

Medical Mycology, 2021
AbstractPrototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis ...
Takahisa Watanabe, Tomohiro Ishikawa, Hirotaka Sato, Noriyuki Hirose, Lisa Nonaka, Kaori Matsumura, Akira Masubuchi, Kazuko Nishimura, Michiaki Masuda   +8 more
openaire   +2 more sources