Results 51 to 60 of about 4,848 (182)
Detection of ERG11 point mutations in Iranian fluconazoleresistant Candida albicans isolates
Current Medical Mycology, 2019 Background and Purpose: Candidiasis is referred to a group of superficial anddeep-tissue fungal infections often caused by Candida albicans. The superficialinfections affect the oral, oropharynx, esophagus, and vaginal mucosa. The treatmentof choice for these infections is the use of azoles, such as fluconazole.
Ali Sardari +2 more
openaire +3 more sources
Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis [PDF]
Iranian Biomedical Journal, 2017 Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms.The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined.
Lotfali, Ensieh +7 more
openaire +2 more sources
Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky +9 more
doaj +1 more source
Biochemical research elucidating metabolic pathways in Pneumocystis*
Parasite, 2010 Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of ...
Kaneshiro E.S.
doaj +1 more source
In Vitro and In Vivo Effects of 14α-Demethylase ( ERG11 ) Depletion in Candida glabrata [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT Sterol 14α-demethylase ( ERG11 ) is the target enzyme of azole antifungals that are widely used for the treatment of fungal infections. Candida glabrata is known to be less susceptible to fluconazole than most Candida albicans strains, and the ...
H, Nakayama +3 more
openaire +2 more sources
Microorganisms, 2019 Candida albicans is an opportunistic fungal pathogen of humans. Treatment of C. albicans infections relies on azoles, which target the lanosterol 14α-demethylase (Erg11p) encoded by the ERG11 gene.
Jakub Suchodolski +3 more
doaj +1 more source
, 2021 © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC).
Navarro-Rodríguez P; López-Fernández L; Martin-Vicente A; Guarro J; Capilla J
core
Antifungal susceptibility and detection of mutant ERG11 gene in vaginal Candida isolates in University of Uyo Teaching Hospital, Uyo, Nigeria [PDF]
, 2020 Background: Candida vulvovaginitis is an important cause of morbidity among women. Fluconazole and other azoles are among the commonest antifungal agents used for the treatment of this condition.
Ikenyi, CL, Atting, IA, Ekuma, AE
core +1 more source
Journal of Global Antimicrobial Resistance, 2020 Introduction: Fluconazole resistance in Candida tropicalis health care–associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. Materials and methods: A total
Nidhi Pandey +3 more
doaj +1 more source
Antibiotics, 2021 Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang +9 more
doaj +1 more source