Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller +31 more
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Infection and Drug Resistance, 2022 Arome Solomon Odiba,1,2 Olanrewaju Ayodeji Durojaye,3– 5 Ifeoma Maureen Ezeonu,6 Anthony Christian Mgbeahuruike,7 Bennett Chima Nwanguma1,2 1Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, 410001 ...
Odiba AS +4 more
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Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida auris
Antimicrobial Agents and Chemotherapy, 2021 Candida auris is a novel Candida species that has spread in all continents, causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant to
Jizhou Li +5 more
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Characterization of ERG11 Gene in Drug-Resistant Candida Albicans Isolated from Iranian Cases of Recurrent Vulvovaginal Candidiasis [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2020 Background & Aims: Candida albicans is the most common fungal pathogen of human infections. C. albicans is responsible for significant mucosal infections such as vulvovaginitis in women.
Kambiz Diba +3 more
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Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata [PDF]
, 2014 Acquisition of azole resistance by clinically relevant yeasts in nature may result in a significant, yet undetermined, impact in human health. The main goal of this study was to assess the development of cross-resistance between agricultural and clinical
Estevinho, Leticia M. +8 more
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Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky +9 more
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Biochemical research elucidating metabolic pathways in Pneumocystis*
Parasite, 2010 Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of ...
Kaneshiro E.S.
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Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes [PDF]
, 2017 Traditional approaches to drug discovery are frustratingly inefficient and have several key limitations that severely constrain our capacity to rapidly identify and develop novel experimental therapeutics.
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Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]
, 2015 The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia +2 more
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Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT In Candida albicans , the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in ...
Stephanie A, Flowers +4 more
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