Results 71 to 80 of about 4,848 (182)

Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing

BMC Microbiology, 2009
Background Amino acid substitutions in the target enzyme Erg11p of azole antifungals contribute to clinically-relevant azole resistance in Candida albicans.
Ellis David, Pantarat Namfon, McNicholas Paul, Wang Bin, Sorrell Tania C, Kong Fanrong, Wang Huiping, Xiao Meng, Widmer Fred, Chen Sharon CA   +9 more
doaj   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrata [PDF]

, 2021
Abstract Azoles, the most commonly used antifungal drugs, specifically inhibit the fungal lanosterol α-14 demethylase enzyme, which is referred to as Erg11. Inhibition of Erg11 ultimately leads to a reduction in ergosterol production, an essential fungal membrane sterol. Many Candida
Bao Gia Vu, W. Scott Moye-Rowley
openaire   +1 more source

Basal expression of ERG11, MDR1 and CDR1 genes in clinical isolates of Candida albicans from Ecuador: insights into azole resistance surveillance

All Life
Introduction Candida albicans is an opportunistic pathogen linked to severe, often fatal, infections. Azoles are the first line of treatment, but its resistance has increasingly been reported worldwide.
Elisa María Sánchez-Villacreses, Juan Carlos Tapia, María José Cáceres-Valdiviezo, Gabriel Morey-León, Juan Carlos Fernández-Cadena, Derly Madeleiny Andrade-Molina   +5 more
doaj   +1 more source

Comparative genomics reveals lineage‐associated structural variation and diversification in a barley fungal pathogen

New Phytologist, EarlyView.
Genome‐wide copy‐number variation landscape highlights structural divergence across Puccinia hordei isolates and potentially links Cyp51 amplification to fungicide insensitivity. Summary Leaf rust, caused by Puccinia hordei, is a major barley disease worldwide.
Xiaohui Yu, Mumta Chhetri, Mafruha Hasan, Thomas H. Roberts, Peng Zhang, Robert F. Park, Yi Ding   +6 more
wiley   +1 more source

Chemical Profiling, Box–Behnken Optimisation, Antimicrobial Activity, and Molecular Docking Study of Z‐Ligustilide Rich Essential Oil From Himalayan Angelica glauca Edgew.

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ABSTRACT Angelica glauca Edgew., a high‐altitude Himalayan medicinal plant, is an important source of bioactive essential oil rich in phthalide derivatives. The present study investigated the influence of environmental conditions and extraction parameters on essential oil yield and chemical composition, with particular emphasis on Z‐ligustilide ...
Balam Singh Bisht, Mahesh Chandra Vishwakarma, Prakash Chandra Mathpal, Jyoti Niwas Pant, Hemant Kumar Joshi, Himanshu Rawat, Chandra Shekhar Mathela   +6 more
wiley   +1 more source

Azole Resistance in Cryptococcus gattii from the Pacific Northwest: Investigation of the Role of ERG11 [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT Cryptococcus gattii is responsible for an expanding epidemic of serious infections in Western Canada and the Northwestern United States (Pacific Northwest). Some patients with these infections respond poorly to azole antifungals, and high azole MICs have been reported in Pacific Northwest C ...
Charles E, Gast, Luiz R, Basso, Igor, Bruzual, Brian, Wong   +3 more
openaire   +2 more sources

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species [PDF]

Memórias do Instituto Oswaldo Cruz, 2016
The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles.
Silva, Danielly Beraldo dos Santos, Rodrigues, Luana Mireli Carbonera, Almeida, Adriana Araújo de, Oliveira, Kelly Mari Pires de, Grisolia/, Alexéia Barufatti   +4 more
openaire   +4 more sources

Evaluation of virulence factors and azole resistance mechanisms of Candida tropicalis isolates from head and neck cancer patients with OPC

Iranian Journal of Microbiology, 2023
Background and Objectives: Candida tropicalis is one of the major non-albicans species causing nosocomial infection. There is limited data about mechanisms of azole-resistance and virulence factors of Candida tropicalis.
Zahra Jahanshiri, Soheila Manifar, Farahnaz Hatami   +2 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source