Results 71 to 80 of about 3,777 (166)
mSphereThe widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism.
Pengju Yu +7 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2015 Objective: To investigate the azole susceptibility of Candida albicans (C. albicans) from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole resistance. Methods: Three hundred and two
Bin Wang +8 more
doaj +1 more source
ChemistrySelect, Volume 11, Issue 19, 20 May 2026.This study highlights the antifungal potential of 2‐mercaptobenzothiazole (MBT) and sulfonamides against multidrug‐resistant Candida albicans. In vitro assays and molecular docking with lanosterol 14α‐demethylase (L14αDM) reveal favorable activity and binding, supporting their repositioning as promising antifungal candidates. ABSTRACT Fungal infections
Bruno A. de Oliveira +6 more
wiley +1 more source
Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species [PDF]
Memórias do Instituto Oswaldo Cruz, 2016 The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles.
Silva, Danielly Beraldo dos Santos +4 more
openaire +4 more sources
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT Wine yeasts play a central role in alcoholic fermentation and significantly contribute to the sensory attributes of wines through cellular autolysis during lees aging (sur lie), especially in white wines. This process releases organic compounds that alter the wine's chemical and sensory profile.
José Ricardo Machado dos Santos +1 more
wiley +1 more source
ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection [PDF]
International Journal of Oral Science, 2018 AbstractThe hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form ...
Zhou, Yujie +10 more
openaire +2 more sources
Mycoses, Volume 69, Issue 5, May 2026.ABSTRACT Background The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. Methods Fourteen azole resistant Candida glabrata clinical isolates were collected from a Lebanese hospital and analysed through whole genome sequencing for ...
Christy Chedraoui +9 more
wiley +1 more source
Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations [PDF]
Journal of Antimicrobial Chemotherapy, 2008 To investigate fluconazole susceptibility of Candida albicans from non-AIDS patients and to analyse the relationship between mutations in the ERG11 gene of these isolates and fluconazole resistance.Four hundred and twenty-six clinical isolates of Candida species were collected. Fluconazole susceptibility was tested in vitro using microdilution and disc
Yonghao, Xu, Lamei, Chen, Chunyang, Li
openaire +2 more sources
Exploration, Volume 6, Issue 2, April 2026.We designed and synthesized a dual‐type AIE photosensitizer (named TB) spray, containing a cationic quaternary ammonium unit and a glycosyl‐targeted boronic acid moiety, characterized for the elimination of biofilm infections of Candidozyma auris (C. auris) on high‐touch surfaces.
Xiaoyu Xu +16 more
wiley +1 more source
The Epidemiology and Infection Control of Candida Auris in Shanghai
Mycoses, Volume 69, Issue 4, April 2026.ABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Mingjing Wei +8 more
wiley +1 more source