Nanotechnology-driven strategies to overcome azole resistance in Phoma arachidicola: mechanistic insights, resistance dynamics, and translational barriers [PDF]
Frontiers in Plant ScienceAzole fungicides are central to peanut disease management, yet their durability is increasingly jeopardized by the accelerating emergence of azole-resistant fungal populations, including Phoma arachidicola, the causal agent of peanut web blotch ...
Jinhui Xie +4 more
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Regulation of ABC Transporters and Ergosterol Biosynthesis by the Transcription Factor FvADS-1 Controls Azole Resistance and Virulence in Fusarium verticillioides [PDF]
Journal of FungiFusarium verticillioides is a significant agricultural pathogen and an emerging causative agent of invasive fusariosis in clinical settings. Fusarium species frequently exhibit resistance to available antifungal agents, yet the molecular mechanisms ...
Yajing Yin +5 more
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Azole Resistance in Aspergillus Species Isolated from Clinical Samples: A Nine-Year Single-Center Study in Turkey (2015–2023) [PDF]
Journal of FungiAzole-resistant mycotic infections pose an escalating global health threat, with an estimated 6.5 million invasive fungal infections (IFIs) annually leading to 3.8 million deaths, 68% directly caused by IFIs.
Zeynep Yazgan +2 more
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The transcription factor RttA contributes to sterol regulation and azole resistance in Aspergillus fumigatus [PDF]
mBioMajor mechanisms of azole resistance in Aspergillus fumigatus involve overexpression of the azole target protein encoded by cyp51A. The elevated expression originates from the duplication of an enhancer element in its promoter, serving as a binding ...
Lukas Birštonas +8 more
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High prevalence of azole resistance among environmental Aspergillus fumigatus isolates from outdoor air in Madrid, Spain [PDF]
Frontiers in MicrobiologyIntroductionAspergillus fumigatus has been designated by the World Health Organization (WHO) as a critical fungal pathogen. Its spores are commonly present in the air and are inhaled daily.
Juan Carlos Soto-Debrán +12 more
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RttA, a Zn2-Cys6 transcription factor in Aspergillus fumigatus, contributes to azole resistance [PDF]
Microbiology SpectrumAspergillus fumigatus is a common environmental fungus and the leading cause of aspergillosis, an opportunistic infection in humans and animals. The mortality rate of aspergillosis remains high despite antifungal treatments, with azole antifungals, such ...
Takahito Toyotome +3 more
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Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance in Candida glabrata [PDF]
Microbiology SpectrumFungal infections affect over 6.55 million individuals annually, with Candida glabrata (recently reclassified as Nakaseomyces glabratus) being the second most common cause of invasive candidiasis and candidemia, conditions that carry a high mortality ...
Catrin C. Williams, Jane Usher
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Microbiology Spectrum, 2022 The emergence of antifungal resistance, especially to the most widely used azole class of ergosterol biosynthesis inhibitors, makes fungal infections difficult to treat in clinics and agriculture. When exposed to azoles, fungi can make adaptive responses
Chengcheng Hu +6 more
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Drug Target Insights, 2022 Aspergilli are ubiquitous fungal pathogens associated with several life-threatening infections, especially in immunocompromised patients. Azoles are the first line of treatment for most Aspergillus related infections.
Pooja Sen +4 more
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Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs. [PDF]
PLoS Genetics, 2018 Invasive fungal infections caused by the pathogen Candida albicans have transitioned from a rare curiosity to a major cause of human mortality. This is in part due to the emergence of resistance to the limited number of antifungals available to treat ...
Harley O'Connor Mount +9 more
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