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Fungal Drug Response and Antimicrobial Resistance
Journal of Fungi, 2023 Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor +2 more
doaj +6 more sources
Microorganisms, 2020 In recent years, the role of mitochondria in pathogenic fungi in terms of azole resistance and fungal pathogenicity has been a rapidly developing field. In this review, we describe the molecular mechanisms by which mitochondria are involved in regulating
Jinxing Song +3 more
doaj +3 more sources
Fungal Cell Wall: Emerging Antifungals and Drug Resistance [PDF]
Frontiers in Microbiology, 2019 The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima +2 more
doaj +4 more sources
Development and research progress of anti-drug resistant fungal drugs
Journal of Infection and Public Health, 2022 With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year.
Xiangyi Cui +3 more
doaj +5 more sources
Epigenetic Regulation of Antifungal Drug Resistance
Journal of Fungi, 2022 In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra +3 more
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AI in fungal drug development: opportunities, challenges, and future outlook
Frontiers in Cellular and Infection MicrobiologyThe application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal infections and the challenge of antifungal resistance.
Yanjian Li +4 more
doaj +4 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The incidence of infections due to fungal pathogens has dramatically increased in human populations with weakened or suppressed immune systems.
Sue Jinks-Robertson +2 more
exaly +2 more sources
The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi
Microorganisms, 2023 The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment.
Kylie J. Boyce
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Antifungals and Drug Resistance
Encyclopedia, 2022 Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal).
Chowdhury Mobaswar Hossain +6 more
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An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in Aspergillus fumigatus [PDF]
mBioAntibiotic tolerance paves the way for acquired resistance in bacterial pathogens. However, the mechanisms of tolerance and its evolutionary role in acquired resistance in pathogenic fungi, and particularly in filamentous fungi, remain elusive.
Sandeep Vellanki +4 more
doaj +2 more sources