Results 1 to 10 of about 81,126 (158)

Development and research progress of anti-drug resistant fungal drugs

Journal of Infection and Public Health, 2022
With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year.
Xiangyi Cui, Lanlin Wang, Yuhong Lü, Changwu Yue   +3 more
doaj   +5 more sources

Fungal Drug Response and Antimicrobial Resistance

Journal of Fungi, 2023
Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor, Amparo Pascual-Ahuir, Markus Proft   +2 more
doaj   +4 more sources

Harnessing random peptide mixtures to combat multidrug-resistant fungal infections [PDF]

mBio
Invasive fungal infections are associated with high mortality and are increasingly difficult to treat due to a limited antifungal arsenal and the rapid emergence of drug resistance.
John Adeoye, Yael Belo, Marina Campos Rocha, Hilla Hayby, Aygun Israyilova, Zvi Hayouka, Neta Shlezinger   +6 more
doaj   +2 more sources

Epigenetic Regulation of Antifungal Drug Resistance

Journal of Fungi, 2022
In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra, Mayur Raney, Aditi Pareek, Rupinder Kaur   +3 more
doaj   +1 more source

Antifungal resistance in dermatophytosis: A global health concern

Letters in Animal Biology, 2022
Dermatophytosis is a common dermatological problem in animals as well as humans which is associated with interference in immune function. Unlike the antibacterial resistance which is frequently reported, antifungal resistance is less commonly reported ...
Jubeda Begum, P Das
doaj   +1 more source

The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. [PDF]

PLoS ONE, 2012
The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90 functions in concert with co-chaperones to regulate stability and activation of client proteins ...
Rebecca S Shapiro, Aimee K Zaas, Marisol Betancourt-Quiroz, John R Perfect, Leah E Cowen   +4 more
doaj   +1 more source

The metal chaperone protein MtmA plays important roles in antifungal drug susceptibility in Aspergillus fumigatus

Frontiers in Microbiology, 2022
Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence.
Pengfei Zhai, Yinyan Ma, Wenlong Du, Ling Lu   +3 more
doaj   +1 more source

Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans

mBio, 2023
Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo, Adèle Trottier, Frédérique Moyrand, Jean-Yves Coppée, Corinne Maufrais, Ana Claudia G. Zimbres, Thi Tuong Vi Dang, Alexandre Alanio, Marie Desnos-Ollivier, Isabelle Mouyna, Gérard Péhau-Arnaude, Pierre-Henri Commere, Sophie Novault, Iuliana V. Ene, Leonardo Nimrichter, Marcio L. Rodrigues, Guilhem Janbon   +16 more
doaj   +1 more source

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

mSphere, 2021
Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida ...
Golnoush Madani, Erwin Lamping, Richard D. Cannon   +2 more
doaj   +1 more source

Mitochondria-Mediated Azole Drug Resistance and Fungal Pathogenicity: Opportunities for Therapeutic Development

Microorganisms, 2020
In recent years, the role of mitochondria in pathogenic fungi in terms of azole resistance and fungal pathogenicity has been a rapidly developing field. In this review, we describe the molecular mechanisms by which mitochondria are involved in regulating
Jinxing Song, Jingwen Zhou, Lei Zhang, Rongpeng Li   +3 more
doaj   +1 more source