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The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi. [PDF]
Microorganisms, 2023 The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment. Mutations in key resistance genes such as ERG11 were postulated to be the predominant cause of antifungal drug resistance in the clinic.
Boyce KJ.
europepmc +7 more sources
Epigenetic Regulation of Antifungal Drug Resistance. [PDF]
J Fungi (Basel), 2022 In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance. Emerging resistance to the limited therapeutic options for the treatment of invasive fungal infections is a growing concern.
Patra S, Raney M, Pareek A, Kaur R.
europepmc +6 more sources
Antifungals and Drug Resistance
Encyclopedia, 2022 Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal). Antibiotics also prevent bacterial infections through either bacteriostatic or bactericidal mechanisms.
Lisa Kathleen Ryan +2 more
exaly +5 more sources
Molecular Evolution of Antifungal Drug Resistance [PDF]
Annual Review of Microbiology, 2017 The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The management of infections caused by these organisms is intimately dependent on the efficacy of antifungal agents; however, fungi that are resistant to these treatments are regularly ...
Leah E Cowen +2 more
exaly +4 more sources
Antifungal drug-resistance mechanisms in Candida biofilms. [PDF]
Curr Opin Microbiol, 2023 Infections caused by the Candida species of human fungal pathogens are a significant medical problem because they can disseminate to nearly every organ of the body. In addition, there are only a few classes of antifungal drugs available to treat patients with invasive fungal infections. Candida infections that are associated with biofilms can withstand
Kaur J, Nobile CJ.
europepmc +6 more sources
Antifungal drug resistance: an update. [PDF]
Eur J Hosp Pharm, 2022 The number of antifungal classes is small, and resistance is becoming a much more frequent problem. Much greater emphasis needs to be placed on susceptibility testing and antifungal stewardship. Such efforts demonstrably improve survival and overall clinical outcomes.
Denning DW.
europepmc +5 more sources
Update on Antifungal Drug Resistance. [PDF]
Curr Clin Microbiol Rep, 2015 Invasive fungal infections remain a major source of global morbidity and mortality, especially among patients with underlying immune suppression. Successful patient management requires antifungal therapy. Yet, treatment choices are restricted due to limited classes of antifungal agents and the emergence of antifungal drug resistance.
Perlin DS, Shor E, Zhao Y.
europepmc +4 more sources
Efflux-Mediated Antifungal Drug Resistance [PDF]
Clinical Microbiology Reviews, 2009 SUMMARY Fungi cause serious infections in the immunocompromised and debilitated, and the incidence of invasive mycoses has increased significantly over the last 3 decades. Slow diagnosis and the relatively few classes of antifungal drugs result in high attributable mortality for systemic fungal infections. Azole
Cannon, Richard D. +9 more
openaire +4 more sources
Antifungal drug resistance: evolution, mechanisms and impact. [PDF]
Curr Opin Microbiol, 2018 Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of ...
Revie NM, Iyer KR, Robbins N, Cowen LE.
europepmc +4 more sources
Mechanisms of Antifungal Drug Resistance [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Antifungal therapy is a central component of patient management for acute and chronic mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal drug classes. Clinical management of fungal diseases is further compromised by the emergence of antifungal drug resistance, which eliminates available drug classes as treatment ...
Cowen Leah E +4 more
openaire +3 more sources