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Epigenetic Regulation of Antifungal Drug Resistance [PDF]

Journal of Fungi, 2022
In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra, Mayur Raney, Aditi Pareek, Rupinder Kaur   +3 more
doaj   +4 more sources

The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi [PDF]

Microorganisms, 2023
The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment.
Kylie J. Boyce
doaj   +4 more sources

Antifungal Drug Resistance: An Emergent Health Threat [PDF]

Biomedicines, 2023
Fungal infections, named mycosis, can cause severe invasive and systemic diseases that can even lead to death. In recent years, epidemiological data have recorded an increase in cases of severe fungal infections, caused mainly by a growing number of ...
Antonio Vitiello, Francesco Ferrara, Mariarosaria Boccellino, Annarita Ponzo, Carla Cimmino, Emilio Comberiati, Andrea Zovi, Salvatore Clemente, Michela Sabbatucci   +8 more
doaj   +4 more sources

Antifungal drug-resistance mechanisms in Candida biofilms. [PDF]

Curr Opin Microbiol, 2023
Infections caused by the Candida species of human fungal pathogens are a significant medical problem because they can disseminate to nearly every organ of the body. In addition, there are only a few classes of antifungal drugs available to treat patients with invasive fungal infections. Candida infections that are associated with biofilms can withstand
Kaur J, Nobile CJ.
europepmc   +6 more sources

The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of Candida auris [PDF]

mSphere
Candida auris has emerged as a multidrug-resistant human fungal pathogen that causes infections of high morbidity and mortality. However, the molecular mechanisms underlying pronounced multidrug resistance and host–pathogen interactions are poorly ...
Manju Chauhan, Raju Shivarathri, Ariel A. Aptekmann, Anuradha Chowdhary, Karl Kuchler, Jigar V. Desai, Neeraj Chauhan   +6 more
doaj   +2 more sources

Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformans [PDF]

Frontiers in Cellular and Infection Microbiology
Cryptococcus neoformans is at the top of the list of “most wanted” human pathogens. Only three classes of antifungal drugs are available for the treatment of cryptococcosis.
Zhi-hui Zhang, Liu-liu Sun, Bu-qing Fu, Jie Deng, Cheng-lin Jia, Ming-xing Miao, Feng Yang, Feng Yang, Yong-bing Cao, Tian-hua Yan   +9 more
doaj   +2 more sources

RNAi epimutations conferring antifungal drug resistance are inheritable [PDF]

Nature Communications
Epimutations modify gene expression and lead to phenotypic variation while the encoding DNA sequence remains unchanged. Epimutations mediated by RNA interference (RNAi) and/or chromatin modifications can confer antifungal drug resistance and may impact ...
Carlos Pérez-Arques, María Isabel Navarro-Mendoza, Ziyan Xu, Grit Walther, Joseph Heitman   +4 more
doaj   +2 more sources

On Fruits and Fungi: A Risk of Antifungal Usage in Food Storage and Distribution in Driving Drug Resistance in Candida auris

mBio, 2022
The continuous emergence of antifungal drug resistance is a mounting concern for the treatment of fungal infections worldwide. While many pathogenic fungi exhibit some level of antifungal drug resistance, the identification of Candida auris has brought ...
Vikas Yadav, Joseph Heitman
doaj   +3 more sources

Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris. [PDF]

Nat Microbiol
Carolus H, Sofras D, Boccarella G, Jacobs S, Biriukov V, Goossens L, Chen A, Vantyghem I, Verbeeck T, Pierson S, Lobo Romero C, Steenackers H, Lagrou K, van den Berg P, Berman J, Gabaldón T, Van Dijck P.   +16 more
europepmc   +2 more sources

Fungal Drug Response and Antimicrobial Resistance

Journal of Fungi, 2023
Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor, Amparo Pascual-Ahuir, Markus Proft   +2 more
doaj   +1 more source