The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of <i>Candida auris</i>. [PDF]
mSphereCandida auris has emerged as a multidrug-resistant human fungal pathogen that causes infections of high morbidity and mortality. However, the molecular mechanisms underlying pronounced multidrug resistance and host–pathogen interactions are poorly ...
Chauhan M +6 more
europepmc +2 more sources
Aneuploidy underlies brefeldin A-induced antifungal drug resistance in <i>Cryptococcus neoformans</i>. [PDF]
Front Cell Infect MicrobiolCryptococcus neoformans is at the top of the list of “most wanted” human pathogens. Only three classes of antifungal drugs are available for the treatment of cryptococcosis.
Zhang ZH +8 more
europepmc +2 more sources
An insight into new strategies to combat antifungal drug resistance. [PDF]
Drug Des Devel Ther, 2018 Yan-Hua Zheng,1 Yue-Yun Ma,2 Yi Ding,3 Xie-Qun Chen,1 Guang-Xun Gao1 1Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China; 2Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth ...
Zheng YH +4 more
europepmc +2 more sources
Carbohydrate derived fulvic acid : an in vitro investigation of a novel membrane active antiseptic agent against Candida albicans biofilms [PDF]
, 2012 Carbohydrate derived fulvic acid (CHD-FA) is a heat stable low molecular weight, water soluble, cationic, colloidal material with proposed therapeutic properties.
Murray, Colin +7 more
core +4 more sources
Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata
Microbiology Spectrum, 2022 Candida glabrata is poised to adapt to drug pressure rapidly and acquire antifungal resistance leading to therapeutic failure. Given the limited antifungal armamentarium, there is an unmet need to explore new targets or therapeutic strategies for ...
Shuying Yu +7 more
doaj +1 more source
Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]
, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon +25 more
core +2 more sources
Fungal biofilm resistance [PDF]
, 2012 Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Ramage, Gordon +7 more
core +1 more source
Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]
, 2010 Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Sonashia Velho-Pereira +1 more
core +1 more source
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Antibiotics, 2020 The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar +8 more
doaj +1 more source
HIV & AIDS Review. International Journal of HIV-Related Problems, 2020 Oropharyngeal candidiasis (OPC) is considered the most common fungal infection in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. Antifungal drug, azole group, is the preferred treatment.
Satutya Wicaksono +4 more
doaj +1 more source