Results 31 to 40 of about 4,137,509 (275)
mBio, 2022 Candida auris exhibits resistance to multiple antifungal drug classes and sterilization agents, posing threats to the immunocompromised worldwide. Among the four major geographical clades, the East Asian clade 2 isolates of C.
Aswathy Narayanan +10 more
doaj +1 more source
Artemisinin Targets Transcription Factor PDR1 and Impairs Candida glabrata Mitochondrial Function
Antioxidants, 2022 A limited number of antifungal drugs, the side-effect of clinical drugs and the emergence of resistance create an urgent need for new antifungal treatment agents. High-throughput drug screening and in-depth drug action mechanism analyzation are needed to
Pan Zhu +3 more
doaj +1 more source
Genetic basis of antifungal drug resistance [PDF]
Current Fungal Infection Reports, 2009 Antifungal resistance caused by mutations of the drug target, overexpression of the drug target, and drug efflux by the upregulation of transporters is increasingly common. Recently our understanding of fungal drug resistance has been advanced by the identification of three key transcriptional regulators of resistance: Tac1p, Upc2p, and Mrr1p.
Chelsea, Marie, Theodore C, White
openaire +2 more sources
Antifungal resistance: current trends and future strategies to combat [PDF]
, 2017 Nathan P Wiederhold Department of Pathology and Laboratory Medicine, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Abstract: Antifungal resistance represents a major clinical challenge to ...
Nathan Wiederhold, Wiederhold NP
core +1 more source
Exploring the Molecular Basis of Antifungal Synergies Using Genome-Wide Approaches
Frontiers in Microbiology, 2012 Drug resistance poses a significant challenge in antifungal therapy since resistance has been found for all known classes of antifungal drugs. The discovery of compounds that can act synergistically with antifungal drugs is an important strategy to ...
Ameeta eAgarwal +6 more
doaj +1 more source
F1000Research, 2017 Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa +1 more
doaj +1 more source
F1000Research, 2016 Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa +1 more
doaj +1 more source
mBio, 2023 Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo +16 more
doaj +1 more source
Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress
Journal of Fungi, 2022 Multidrug resistance, defined as the resistance to multiple drugs in different categories, has been an increasing serious problem. Limited antifungal drugs and the rapid emergence of antifungal resistance prompt a thorough understanding of how the ...
Mi Zhou +7 more
doaj +1 more source
Turkish Journal of Hematology, 2018 Invasive fungal infections caused by drug-resistant organisms are an emerging threat to heavily immunosuppressed patients with hematological malignancies.
Maria N. Gamaletsou +2 more
doaj +1 more source