Results 51 to 60 of about 68,714 (277)

Mechanisms of echinocandin antifungal drug resistance. [PDF]

Ann N Y Acad Sci, 2015
Fungal infections due to Candida and Aspergillus species cause extensive morbidity and mortality, especially among immunosuppressed patients, and antifungal therapy is critical to patient management. Yet only a few drug classes are available to treat invasive fungal diseases, and this problem is compounded by the emergence of antifungal resistance ...
Perlin DS.
europepmc   +4 more sources

Species Distribution and in Vitro Antifungal Susceptibility of Oral Yeast Isolates from Tanzanian HIV-Infected Patients With Primary and Recurrent Oropharyngeal Candidiasis. [PDF]

, 2008
\ud In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis.
Rijs Antonius JMM, Mugusi Ferdinand, Simon Elison NM, van der Ven, A.J., Rijs, A.J.M.M, Verweij, P.E., Verweij, P.E, Simon, Elison N M, Matee, Mecky I N, Palenstein Helderman, W.H. van, Moshi, M.J, Van Palenstein Helderman, W.H, Moshi, Mainen J, Rijs, Antonius J M M, Hamza, O.J.M., Wim Helderman, Frans HM Mikx, Simon, E.N.M., Verweij, Paul E, Ferdinand Mugusi, Mugusi, Ferdinand, Hamza, Omar J M, van der Ven André JAM, Antonius JMM Rijs, Mikx, F.H.M., Rijs, A.J.M.M., Elison NM Simon, Ven, A.J.A.M. van der, Mikx Frans HM, Matee Mecky IN, Matee, M.I.N, Simon, E.N., Verweij Paul E, Paul E Verweij, Helderman, W.H.P., Moshi, M.J., Moshi Mainen J, Simon, E.N.M, Helderman, Wim H van Palenstein, André JAM van der Ven, Mecky IN Matee, Mikx, Frans H M, Omar JM Hamza, Mugusi, F., van der Ven, André J A M, Mainen J Moshi, Matee, M.I.N., Mikx, F.H.M, Van der Ven, A.J.A.M, Hamza, O.J.M, Hamza Omar JM, Helderman Wim   +51 more
core   +1 more source

MARDy: mycology antifungal resistance database [PDF]

, 2018
Summary: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance.
Fisher, Matthew C, Thomas Sewell, Abdolrasouli, Alireza, Rhodes, Johanna, Jennifer M G Shelton, Matthew C Fisher, Farrer, Rhys A, Farrer, Rhys, Rhodes, JL, Farrer, Rhys A., Shelton, Jennifer M.G., Nash, Anthony, Anthony Nash, Rhys A Farrer, Shelton, Jennifer M G, Fisher, Matthew C., Fisher, Matthew, Sewell, Thomas, Alireza Abdolrasouli, Shelton, Jennifer, Johanna Rhodes, Rhodes, Johanna; id_orcid   +21 more
core   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Antifungal drug resistance: evolution, mechanisms and impact. [PDF]

Curr Opin Microbiol, 2018
Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of ...
Revie NM, Iyer KR, Robbins N, Cowen LE.
europepmc   +4 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides.

PLoS Genetics, 2019
Mucormycosis-an emergent, deadly fungal infection-is difficult to treat, in part because the causative species demonstrate broad clinical antifungal resistance.
Zanetta Chang, R Blake Billmyre, Soo Chan Lee, Joseph Heitman   +3 more
doaj   +1 more source

Defining the frontiers between antifungal resistance, tolerance and the concept of persistence

, 2015
A restricted number of antifungal agents are available for the therapy of fungal diseases. With the introduction of epidemiological cut-off values for each agent in important fungal pathogens based on the distribution of minimal inhibitory concentration (
Delarze, E., Sanglard, D.
core   +1 more source

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Predicting the emergence of resistance to antifungal drugs [PDF]

FEMS Microbiology Letters, 2001
The emergence of antifungal drug resistance is inevitable. Here I discuss antibiotic resistance in the context of the adaptive potential of fungi and I propose an approach to predicting the evolution of antifungal resistance using experimental evolution of DNA sequences and microbial populations.
openaire   +2 more sources