Results 41 to 50 of about 68,714 (277)

Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans

mBio, 2023
Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo, Adèle Trottier, Frédérique Moyrand, Jean-Yves Coppée, Corinne Maufrais, Ana Claudia G. Zimbres, Thi Tuong Vi Dang, Alexandre Alanio, Marie Desnos-Ollivier, Isabelle Mouyna, Gérard Péhau-Arnaude, Pierre-Henri Commere, Sophie Novault, Iuliana V. Ene, Leonardo Nimrichter, Marcio L. Rodrigues, Guilhem Janbon   +16 more
doaj   +1 more source

Candida antifungal drug resistance in sub-Saharan African populations: A systematic review [version 2; referees: 2 approved]

F1000Research, 2017
Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa, Pedro Miguel dos Santos Abrantes   +1 more
doaj   +1 more source

Development and research progress of anti-drug resistant fungal drugs

Journal of Infection and Public Health, 2022
With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year.
Xiangyi Cui, Lanlin Wang, Yuhong Lü, Changwu Yue   +3 more
doaj   +1 more source

Candidemia : evolution of drug resistance and novel therapeutic approaches [PDF]

, 2021
Candidemia and invasive candidiasis are the most common healthcare-associated invasive fungal infections, with a crude mortality rate of 25-50%. Candida albicans remains the most frequent etiology, followed by C. glabrata, C.
Prigitano, Anna, Barchiesi, Francesco, Brescini, Lucia, Morroni, Gianluca, Tortorano, Anna Maria   +4 more
core   +1 more source

Candida antifungal drug resistance in sub-Saharan African populations: A systematic review [version 1; referees: 2 approved]

F1000Research, 2016
Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa, Pedro Miguel dos Santos Abrantes   +1 more
doaj   +1 more source

A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections. [PDF]

Infect Drug Resist, 2018
Sanyuktha Tulasidas,1 Pooja Rao,2 Sevitha Bhat,2 Radhakrishna Manipura1 1Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Manipal, India; 2Department of Microbiology, Kasturba Medical College, Manipal ...
Tulasidas S, Rao P, Bhat S, Manipura R.
europepmc   +2 more sources

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]

, 2010
Peer ...
Mullick, Alaka, Malcolm Whiteway, Jansen, Gregor, Whiteway, Malcolm, David Y Thomas, Harcus Doreen, Lee Anna Y., Vanier, Ghyslaine, Lee, Anna Y., Thomas, David Y, Michael Hallett, Vanier Ghyslaine, Munro, Carol A., Elias Epp, Epp Elias, Gregor Jansen, Thomas, David Y., Ghyslaine Vanier, Jansen Gregor, Harcus, Doreen, Anna Y Lee, Alaka Mullick, Hallett, Michael, Lee, Anna Y, Thomas David Y., Hallett Michael, Whiteway Malcolm, Carol A Munro, Mullick Alaka, Epp, Elias, Don C Sheppard, Sheppard Don C., Munro Carol A., Doreen Harcus, Sheppard, Don C, Sheppard, Don C., Munro, Carol A   +36 more
core   +1 more source

Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds

, 2010
Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Sonashia Velho-Pereira, Nandkumar M. Kamat   +1 more
core   +1 more source

Resistance to echinocandin-class antifungal drugs [PDF]

Drug Resistance Updates, 2007
Invasive fungal infections cause morbidity and mortality in severely ill patients, and limited drug classes restrict treatment choices. The echinocandin drugs are the first new class of antifungal compounds that target the fungal cell wall by blocking beta-1,3-d-glucan synthase.
openaire   +2 more sources

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

mSphere, 2021
Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida ...
Golnoush Madani, Erwin Lamping, Richard D. Cannon   +2 more
doaj   +1 more source