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A Review of Antifungal Resistance in West Africa [PDF]

Borneo Journal of Pharmacy
Knowledge of local and regional antimicrobial resistance (AMR) is important for clinical decision-making. However, surveillance capacity for fungal infections let alone antifungal resistance is lacking throughout West Africa, and current antifungal ...
Abraham Bwalhuma Muhindo, Adamu Almustapha Aliero, Festo Mwebaze Syalhasha, Ibrahim Ntulume, Emmanuel Eilu, Martin Odoki, Joe Mutebi   +6 more
doaj   +2 more sources

Deciphering the multidrug resistance paradigm in Candida auris

Antimicrobial Agents and Chemotherapy
Candida auris has garnered substantial clinical and public health attention for its widespread antifungal resistance. Most isolates are resistant to fluconazole, and many, to other drug classes, with acquired resistance to all clinically available ...
Darian J. Santana, Nicholas C. Cauldron, P. David Rogers, Christina A. Cuomo   +3 more
doaj   +1 more source

Antifungal Resistance Regarding Malassezia pachydermatis: Where Are We Now?

Journal of Fungi, 2020
Malassezia pachydermatis is a yeast inhabiting the skin and ear canals in healthy dogs. In the presence of various predisposing conditions it can cause otitis and dermatitis, which are treated with multiple antifungal agents, mainly azole derivatives ...
Andrea Peano, Elizabeth Johnson, Elisa Chiavassa, Paolo Tizzani, Jacques Guillot, Mario Pasquetti   +5 more
doaj   +1 more source

Exploring the Molecular Basis of Antifungal Synergies Using Genome-Wide Approaches

Frontiers in Microbiology, 2012
Drug resistance poses a significant challenge in antifungal therapy since resistance has been found for all known classes of antifungal drugs. The discovery of compounds that can act synergistically with antifungal drugs is an important strategy to ...
Ameeta eAgarwal, Siddharth eTripathi, Tao eXu, Melissa eJacob, Xing-Cong eLi, Alice eClark, Alice eClark   +6 more
doaj   +1 more source

Recent Systemic Antifungal Exposure and Nonsusceptible Candida in Hospitalized Patients, South Africa, 2012–2017

Emerging Infectious Diseases
Candida bloodstream infections, and their increasing antifungal resistance, are a global concern. In this cross-sectional study, we analyzed 2,443 culture-confirmed candidemia cases reported in South Africa during 2012–2017 to assess the effect of ...
Charlotte Rabault, Liliwe Shuping, Ruth Mpembe, Vanessa Quan, Fanny Lanternier, Olivier Lortholary, Olivier Paccoud, Nelesh P. Govender   +7 more
doaj   +1 more source

Investigating Antifungal Susceptibility in Candida Species With MALDI-TOF MS-Based Assays

Frontiers in Cellular and Infection Microbiology, 2019
Half of invasive fungal infections lead to death. Amongst pathogenic fungi, the most widespread species belong to the Candida genus and vary in their susceptibility to antifungal drugs.
Margot Delavy, Andrea R. Dos Santos, Clara M. Heiman, Alix T. Coste   +3 more
doaj   +1 more source

Management of Patients with Candida auris Fungemia at Community Hospital, Brooklyn, New York, USA, 2016–2018

Emerging Infectious Diseases, 2019
Candida auris is an emerging fungus that can cause invasive infections. It is associated with high mortality rates and resistance to multiple classes of antifungal drugs and is difficult to identify with standard laboratory methods.
Jenny YeiSol Park, Nicole Bradley, Steven Brooks, Sibte Burney, Chanie Wassner   +4 more
doaj   +1 more source

Antifungal Resistance Patterns of Oral and Intestinal Candida Isolates Among People Living with HIV in a Tertiary Hospital in Gabon: A Cross-Sectional Study

Microorganisms
Digestive candidiasis is a major opportunistic infection among people living with HIV (PLHIV). In Gabon, data on antifungal resistance remain limited. This study aimed to characterise Candida colonisation and antifungal resistance according to anatomical
Geril Sekangue Obili, Bridy Chelsy Moutombi Ditombi, Charlene Manomba Boulingui, Roger Hadry Sibi Matotou, Joyce Coëlla Mihindou, Dimitri Mabicka Moussavou, Denise Patricia Mawili Mboumba, Marielle Karine Bouyou-Akotet   +7 more
doaj   +1 more source

Prevalence and diversity of antifungal resistance in Fusarium isolates across clinical and agricultural settings in the United States

Antimicrobial Agents and Chemotherapy
Disseminated fusariosis and chronic superficial fusariosis require effective strategies to control fungal growth and prevent systemic spread. This study presents an updated, comprehensive analysis of antifungal susceptibility in 174 Fusarium isolates ...
Emilie Applebach, Kincer Amburgey-Crovetti, Wayne L. Bakotic, Tika B. Adhikari, Nathan P. Wiederhold, Shelby Hodges, Tomoko Y. Steen, Richard Calderone, Dongmei Li   +8 more
doaj   +1 more source

Evaluation of antifungal susceptibility testing in Candida isolates by Candifast and disk-diffusion method

Indian Journal of Pathology and Microbiology, 2014
With the increase in invasive fungal infections due to Candida species and resistance to antifungal therapy, in vitro antifungal susceptibility testing is becoming an important part of clinical microbiology laboratories.
Sidhartha Giri, Anupma Jyoti Kindo
doaj   +1 more source