Results 1 to 10 of about 116,695 (299)

Antifungal Susceptibility Data and Epidemiological Distribution of Candida spp.: An In Vitro Five-Year Evaluation at University Hospital Policlinico of Catania and a Comprehensive Literature Review

Antibiotics
Background: Invasive fungal infections represent a concerning healthcare issue, with Candida spp. reported as the main aetiological agent. Candida spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes
Maddalena Calvo, Guido Scalia, Laura Trovato   +2 more
doaj   +1 more source

The role of gene copy number variation in antimicrobial resistance in human fungal pathogens

npj Antimicrobials and Resistance
Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms.
Adarsh Jay, David F. Jordan, Aleeza Gerstein, Christian R. Landry   +3 more
doaj   +1 more source

Fungal Infections, Treatment and Antifungal Resistance: The Sub-Saharan African Context

Therapeutic Advances in Infectious Disease
Fungal pathogens cause a wide range of infections in humans, from superficial to disfiguring, allergic syndromes, and life-threatening invasive infections, affecting over a billion individuals globally.
Emily Boakye-Yiadom, Alex Odoom, Abdul-Halim Osman, Onyansaniba K. Ntim, Fleischer C. N. Kotey, Bright K. Ocansey, Eric S. Donkor   +6 more
doaj   +1 more source

Shifting Epidemiology and Antifungal Susceptibility Patterns of Clinical Fungal Isolates in an Intensive Care Unit (ICU) from Bucharest, Romania: A Retrospective Observational Study

Antibiotics
Background: Antifungal resistance among Candida species represents a growing clinical challenge, particularly in the context of increasing prevalence of non-albicans species. Methods: We conducted a retrospective analysis of 747 fungal isolates collected
Madalina (Preda) Solomon, Beatrice Mahler, Oana Popescu, Lia-Mara Ditu, Irina Gheorghe-Barbu, Laura Ioana Chivu, Loredana Sabina Cornelia Manolescu   +6 more
doaj   +1 more source

Candida parapsilosis candidemia in children admitted to a tertiary hospital in Turkey: clinical features and antifungal susceptibility

Microbiology Spectrum
In recent years, the incidence and drug resistance of Candida parapsilosis have increased. Our study aimed to determine the antifungal sensitivity of C. parapsilosis and the clinical and demographic characteristics of children with candidemia.
Fatma Tuğba Çetin, Ümmühan Çay, Murat Polat, Fatma Kılınç, Asena Ünal, Nisa Nur Tapaç, Özlem Özgür Gündeşlioğlu, Derya Alabaz, Sevcan Bilen, Filiz Kibar, Nazlı Totik   +10 more
doaj   +1 more source

Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformans

Frontiers in Cellular and Infection Microbiology
Cryptococcus neoformans is at the top of the list of “most wanted” human pathogens. Only three classes of antifungal drugs are available for the treatment of cryptococcosis.
Zhi-hui Zhang, Liu-liu Sun, Bu-qing Fu, Jie Deng, Cheng-lin Jia, Ming-xing Miao, Feng Yang, Feng Yang, Yong-bing Cao, Tian-hua Yan   +9 more
doaj   +1 more source

Antifungal susceptibility, molecular epidemiology, and clinical risk factors of Candida glabrata in intensive care unit in a Chinese Tertiary Hospital

Frontiers in Cellular and Infection Microbiology
BackgroundThe increasing incidence and high mortality rate of Candida glabrata infection in ICU patients is an important issue. Therefore, it is imperative to investigate the antifungal susceptibility profiles and epidemiological characteristics in local
Si-Jia Huang, Si-Jia Huang, Geng Lv, Geng Lv, Yi-Hui Song, Jun-Tao Zhao, Jin-Yan Liu, Lu-Ling Wang, Lu-Ling Wang, Ming-Jie Xiang, Ming-Jie Xiang   +10 more
doaj   +1 more source

Frequency and Antifungal Susceptibility Patterns of Candida Species Isolated from Clinical Samples of Patients Attending to a Tertiary Healthcare Setting in Karnataka, India

Journal of Nature and Science of Medicine
Context: Candida species are common pathogens causing a range of infections from mucocutaneous to systemic. The increasing antifungal resistance among Candida species presents a substantial challenge in healthcare settings.
Asem Ali Ashraf, Vimal Kumar Karnaker, Ganesh Ramanath, Anulekha Roy, Athira Raveendran, Sayantani Nag   +5 more
doaj   +1 more source

Time to Think Antifungal Resistance

Pathogens and Immunity
Increased antifungal resistance is exacerbating the burden of invasive fungal infections, as well as potentially contributing to the increase in resistant dermatomycoses.
Thomas McCormick, Mahmoud Ghannoum
doaj   +1 more source

Impact of inter-species hybridisation on antifungal drug response in the Saccharomyces genus

BMC Genomics
Background Antifungal drug resistance presents one of the major concerns for global public health, and hybridization allows the development of high fitness organisms that can better survive in restrictive conditions or in presence of antifungal agents ...
Federico Visinoni, William Royle, Rachel Scholey, Yue Hu, Soukaina Timouma, Leo Zeef, Edward J. Louis, Daniela Delneri   +7 more
doaj   +1 more source