Results 41 to 50 of about 2,517,016 (285)
Resistance to antifungals that target CYP51 [PDF]
Journal of Chemical Biology, 2014 Fungal diseases are an increasing global burden. Fungi are now recognised to kill more people annually than malaria, whilst in agriculture, fungi threaten crop yields and food security. Azole resistance, mediated by several mechanisms including point mutations in the target enzyme (CYP51), is increasing through selection pressure as a result of ...
Josie Parker +5 more
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Antifungal resistance: current trends and future strategies to combat [PDF]
, 2017 Nathan P Wiederhold Department of Pathology and Laboratory Medicine, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Abstract: Antifungal resistance represents a major clinical challenge to ...
Nathan Wiederhold, Wiederhold NP
core +1 more source
Emerging threats in antifungal-resistant fungal pathogens
Frontiers in Medicine, 2016 The use of antifungal drugs in the therapy of fungal diseases can lead to the development of antifungal resistance. Resistance has been described for virtually all antifungal agents in diverse pathogens including Candida and Aspergilli species.
Dominique eSanglard
doaj +1 more source
Antifungal Resistance in Pathogenic Fungi [PDF]
Clinical Infectious Diseases, 2002 Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of
Sofia, Perea, Thomas F, Patterson
openaire +2 more sources
HIV & AIDS Review. International Journal of HIV-Related Problems, 2020 Oropharyngeal candidiasis (OPC) is considered the most common fungal infection in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. Antifungal drug, azole group, is the preferred treatment.
Satutya Wicaksono +4 more
doaj +1 more source
Mechanisms of Antifungal Drug Resistance [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Antifungal therapy is a central component of patient management for acute and chronic mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal drug classes. Clinical management of fungal diseases is further compromised by the emergence of antifungal drug resistance, which eliminates available drug classes as treatment ...
Cowen Leah E +4 more
openaire +3 more sources
Examining Signatures of Natural Selection in Antifungal Resistance Genes Across Aspergillus Fungi
Frontiers in Fungal Biology, 2021 Certain Aspergillus fungi cause aspergillosis, a set of diseases that typically affect immunocompromised individuals. Most cases of aspergillosis are caused by Aspergillus fumigatus, which infects millions of people annually.
Renato Augusto Corrêa dos Santos +7 more
doaj +1 more source
Candidiasis and Mechanisms of Antifungal Resistance [PDF]
Antibiotics, 2020 Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which is caused by more than 20 types of Candida sp., with C. albicans being the most common. These are pathogenic yeast and are usually present in the normal microbiome.
Somanon Bhattacharya +2 more
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MARDy: Mycology Antifungal Resistance Database [PDF]
, 2019 This is the final version. Available from the publisher via the DOI in this record.Summary: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns,
Abdolrasouli, A +6 more
core +2 more sources
Antifungal resistance on Sporothrix species: an overview [PDF]
Brazilian Journal of Microbiology, 2020 The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this.Published data on databases ...
Stefanie Bressan Waller +5 more
openaire +3 more sources