Mechanisms of Antifungal Drug Resistance [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Antifungal therapy is a central component of patient management for acute and chronic mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal drug classes. Clinical management of fungal diseases is further compromised by the emergence of antifungal drug resistance, which eliminates available drug classes as treatment ...
Cowen Leah E +4 more
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First hospital outbreak of the globally emerging Candida auris in a European hospital [PDF]
, 2016 Background: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016.
Abdolrasouli, A +11 more
core +2 more sources
Antifungal Resistance on the Rise
Journal of Investigative Dermatology, 2023 Comment on : Gupta AK, Cooper EA, Wang T, Polla Ravi S, Lincoln SA, Piguet V, McCarthy LR, Bakotic WL. Detection of Squalene Epoxidase Mutations in United States Patients with Onychomycosis: Implications for Management. J Invest Dermatol. 2023 Dec;143(12):2476-2483.e7. doi: 10.1016/j.jid.2023.04.032. Epub 2023 May 24. PMID: 37236595.
Monod, Michel +2 more
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Antifungal Resistance in Clinical Isolates of Candida glabrata in Ibero-America
Journal of Fungi, 2021 In different regions worldwide, there exists an intra-and inter-regional variability in the rates of resistance to antifungal agents in Candida glabrata, highlighting the importance of understanding the epidemiology and antifungal susceptibility profiles
Erick Martínez-Herrera +6 more
doaj +1 more source
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]
, 2020 Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E. +6 more
core +1 more source
Antifungal Resistance in Pathogenic Fungi [PDF]
Clinical Infectious Diseases, 2002 Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of
Sofia, Perea, Thomas F, Patterson
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Antifungal Resistance and New Strategies to Control Fungal Infections
International Journal of Microbiology, 2012 Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice.
Patrick Vandeputte +2 more
doaj +1 more source
Bloodstream yeast infections: a 15-month survey [PDF]
, 2009 A 15-month survey of 412 bloodstream yeast isolates from 54 Belgian hospitals was undertaken. Candida albicans was the most common species (47.3%) followed by C. glabrata (25.7%), C. parapsilosis (8.0%), C. tropicalis (6.8%) and Saccharomyces cerevisiae (
Detandt, M +3 more
core +1 more source
Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]
, 2011 Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines +5 more
core +2 more sources