Results 61 to 70 of about 116,695 (299)

Use of volatile fingerprints for rapid screening of antifungal agents for efficacy against dermatophyte Trichophyton species [PDF]

, 2010
The potential of using an electronic nose (E-nose) as a rapid technique for screening the responses of dermatophytes to antifungal agents was studied.
Adriaans, B, Barr, Hugh, Magan, Naresh, Sahgal, N, Sahgal, Natasha, Barr, H, Magan, N, Naraghi, Kamran, Adriaans, Beverley, Naraghi, K   +9 more
core   +1 more source

Antifungal Resistance in Clinical Isolates of Candida glabrata in Ibero-America

Journal of Fungi, 2021
In different regions worldwide, there exists an intra-and inter-regional variability in the rates of resistance to antifungal agents in Candida glabrata, highlighting the importance of understanding the epidemiology and antifungal susceptibility profiles
Erick Martínez-Herrera, María Guadalupe Frías-De-León, Rigoberto Hernández-Castro, Eduardo García-Salazar, Roberto Arenas, Esther Ocharan-Hernández, Carmen Rodríguez-Cerdeira   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

MARDy: Mycology Antifungal Resistance Database [PDF]

, 2019
This is the final version. Available from the publisher via the DOI in this record.Summary: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns,
Abdolrasouli, A, Nash, A, Fisher, MC, Farrer, RA, Sewell, T, Shelton, JMG, Rhodes, J   +6 more
core   +4 more sources

Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium. [PDF]

, 2018
<p>is a major cause of candidemia in immunocompromised patients and is characterized by a high-level of fluconazole resistance. In the present study, the acquisition of antifungal resistance and potential clonal spread of were explored at a single ...
K. Lagrou, Spriet, Isabel, Isabel Spriet, P. Becker, Berdieke Goemaere, Marijke Hendrickx, Pierre Becker, Lagrou, Katrien, Hendrickx, Marijke, M. Hendrickx, Goemaere, Berdieke, Becker, Pierre, I. Spriet, Katrien Lagrou, B. Goemaere   +14 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways

Pharmaceuticals
The rising burden of fungal infections presents a significant challenge to global healthcare, particularly with increasing antifungal resistance limiting treatment efficacy.
Helal F. Hetta, Tameem Melhem, Hashim M. Aljohani, Ayman Salama, Rehab Ahmed, Hassabelrasoul Elfadil, Fawaz E. Alanazi, Yasmin N. Ramadan, Basem Battah, Michelangelo Rottura, Matthew Gavino Donadu   +10 more
doaj   +1 more source

In vitro Resistance Pattern of Selected Antifungal Azoles against Candida albicans Biofilms on Silicone Nasogastric Tube [PDF]

, 2019
Prolonged use of implanted medical devices has been linked with device-associated infections. Since enteral tube feeding is increasing worldwide, the present study described the morphology of Candida albicans biofilms on the surface of silicone ...
Nelson R. Villarante, Nina G. Gloriani, Villarante, Nelson R., Salazar, Pauline Bridgette D., Pauline Bridgette D. Salazar, Sumalapao, Derick Erl P., Alegre, Frederico Martin D., Derick Erl P. Sumalapao, Frederico Martin D. Alegre, Gloriani, Nina G.   +9 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance [PDF]

, 2016
Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society.
Brown, N. A., Goldman, G. H.
core   +1 more source