Results 51 to 60 of about 116,042 (299)

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal.

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, Day, Jeremy, T. S. Harrison, J. Day, Loyse, A   +10 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MARDy: Mycology Antifungal Resistance Database [PDF]

, 2019
This is the final version. Available from the publisher via the DOI in this record.Summary: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns,
Abdolrasouli, A, Nash, A, Fisher, MC, Farrer, RA, Sewell, T, Shelton, JMG, Rhodes, J   +6 more
core   +3 more sources

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways

Pharmaceuticals
The rising burden of fungal infections presents a significant challenge to global healthcare, particularly with increasing antifungal resistance limiting treatment efficacy.
Helal F. Hetta, Tameem Melhem, Hashim M. Aljohani, Ayman Salama, Rehab Ahmed, Hassabelrasoul Elfadil, Fawaz E. Alanazi, Yasmin N. Ramadan, Basem Battah, Michelangelo Rottura, Matthew Gavino Donadu   +10 more
doaj   +1 more source

Conformal Metallosaccharide Hybrid Films for Protecting Wood Surfaces From Environmental Damage

Advanced Functional Materials, EarlyView.
Ti‐ribose hybrid films fabricated by molecular layer deposition form a conformal and uniform coating on wood surfaces, which provides water repellence, dimensional stability, and resistance to acidic and alkaline environments, while preserving the natural appearance.
Wenwen Wang, Aranzazu Sierra Fernandez, Gabriele Botta, Evgenii Modin, Iva Šarić Janković, Shidong Ji, Junli Liu, Mato Knez   +7 more
wiley   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Genome-wide investigation of cellular targets and mode of action of the antifungal bacterial metabolite 2,4-diacetylphloroglucinol in Saccharomyces cerevisiae [PDF]

, 2013
Saccharomyces cerevisiae is a proven model to investigate the effects of small molecules and drugs on fungal and eukaryotic cells. In this study, the mode of action of an antifungal metabolite, 2,4-diacetylphloroglucinol (DAPG), was determined.
Troppens, Danielle M., Morrissey, John, Morrissey, John P., Troppens, Danielle, Papkovsky, Dmitri, Dmitriev, Ruslan, O’Gara, Fergal, Dmitriev, Ruslan I., Papkovsky, Dmitri B., O'Gara, Fergal   +9 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Carbohydrate derived fulvic acid: an in vitro investigation of a novel membrane active antiseptic agent against Candida albicans biofilms

, 2012
Carbohydrate derived fulvic acid (CHD-FA) is a heat stable low molecular weight, water soluble, cationic, colloidal material with proposed therapeutic properties.
Brian Jones, Murray, Colin, Bagg, Jeremy, Craig eWilliams, Leighann eSherry, Jones, Brian, Owain Millington, Jose, Anto, Gordon eRamage, Millington, Owain, Leighann Sherry, Anto Jose, Jeremy Bagg, Sherry, Leighann, Colin eMurray, Ramage, Gordon, Colin Murray, Williams, Craig, Anto eJose, Owain eMillington, Brian eJones, Gordon Ramage, Jeremy eBagg, Craig Williams   +23 more
core   +1 more source