Results 71 to 80 of about 116,695 (299)

Biomimetic Vascular Scaffold with Seamless Electrospun Aligned Nanofiber Conduit and 3D‐Printed Coil Reinforcement

Advanced Healthcare Materials, EarlyView.
We introduce a new fabrication method that overcomes the current limitation of tubular gap electrospinning. We successfully fabricated a seamless hollow tube with fibers aligned along the longitudinal axis in diameters as small as 300 µm, and then reinforced it using 4‐axis 3D printing.
Seyed Aliakbar Hosseini Toopghara, Young‐Ook Hwang, In A Kim, Che‐I Hyun, Hochung Ryu, Won‐Jae Kim, Jeong‐Tae Koh, Hyun‐Pil Lim, Jin‐Ho Kang, Sang‐Won Park   +9 more
wiley   +1 more source

Genome-wide investigation of cellular targets and mode of action of the antifungal bacterial metabolite 2,4-diacetylphloroglucinol in Saccharomyces cerevisiae [PDF]

, 2013
Saccharomyces cerevisiae is a proven model to investigate the effects of small molecules and drugs on fungal and eukaryotic cells. In this study, the mode of action of an antifungal metabolite, 2,4-diacetylphloroglucinol (DAPG), was determined.
Troppens, Danielle M., Morrissey, John, Morrissey, John P., Troppens, Danielle, Papkovsky, Dmitri, Dmitriev, Ruslan, O’Gara, Fergal, Dmitriev, Ruslan I., Papkovsky, Dmitri B., O'Gara, Fergal   +9 more
core   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Unveiling genome plasticity as a mechanism of non-antifungal-induced antifungal resistance in Cryptococcus neoformans

Frontiers in Microbiology
Cryptococcus neoformans, a critical priority pathogen designated by the World Health Organization, poses significant therapeutic challenges due to the limited availability of treatment options.
Lijun Zheng, Yi Xu, Liangsheng Guo
doaj   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies

Turkish Journal of Hematology, 2018
Invasive fungal infections caused by drug-resistant organisms are an emerging threat to heavily immunosuppressed patients with hematological malignancies.
Maria N. Gamaletsou, Thomas J. Walsh, Nikolaos V. Sipsas   +2 more
doaj   +1 more source

An insight into new strategies to combat antifungal drug resistance [PDF]

, 2018
Yan-Hua Zheng,1 Yue-Yun Ma,2 Yi Ding,3 Xie-Qun Chen,1 Guang-Xun Gao1 1Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China; 2Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth ...
Chen XQ, Ding Y, Ma YY, Zheng YH, Gao GX
core  

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases

Journal of Biomedical Science
Antifungal resistance represents a growing global health challenge, driven by limited therapeutic options, inadequate use of both clinical and environmental drugs, and the remarkable adaptive capacity of fungal pathogens. While resistance has classically
Silvia Maria Cordeiro Werneck, Ludmila Gouveia-Eufrasio, Gustavo José Cota de Freitas, Daniel Santana de Carvalho, Isabela da Costa César, Luana Rossato, Rafael Wesley Bastos, Nalu Teixeira Aguiar Peres, Daniel Assis Santos   +8 more
doaj   +1 more source