Results 21 to 30 of about 116,042 (299)

Antifungal Resistance in Cryptococcal Infections

Pathogens
Antifungal therapy, especially with the azoles, could promote the incidence of less susceptible isolates of Cryptococcus neoformans and C. gattii species complexes (SC), mostly in developing countries.
Lucas X. Bonfietti, Wellington S. Fava, Marcia S. C. Melhem, Diniz Pereira Leite Júnior, Juliana P. F. Takahashi, Milena Bronze Macioni, Lidiane de Oliveira, Lisandra Siufi de Araújo, Ana Espinel-Ingroff, Anamaria M. M. Paniago, James Venturini   +10 more
core   +4 more sources

Molecular Mechanisms of Antifungal Drug Resistance in Candida Species [PDF]

Journal of Clinical and Diagnostic Research, 2018
Invasive Candidal infections have emerged as one of the major threats to the world. Although, many new antifungal drugs have been developed in the recent years, the emergence of drug resistance has become a major deterrent in the antifungal therapy ...
Lakshmi Krishnasamy, Sharanya Krishnakumar, Govindasamy Kumaramanickavel, Chitralekha Saikumar   +3 more
doaj   +1 more source

Fungal infections: Pathogenesis, antifungals and alternate treatment approaches

Current Research in Microbial Sciences, 2022
Increasing incidence of fungal infections of recent times requires immediate intervention. Fungal infections are seldom construed at initial stages that intensify the severity of infections and complicate the treatment procedures. Fungal pathogens employ
G.Kiran Kumar Reddy, Alwar Ramanujam Padmavathi, Y.V. Nancharaiah   +2 more
doaj   +1 more source

Global Prevalence of Antifungal-Resistant Candida parapsilosis: A Systematic Review and Meta-Analysis

Tropical Medicine and Infectious Disease, 2022
A reliable estimate of Candida parapsilosis antifungal susceptibility in candidemia patients is increasingly important to track the spread of C. parapsilosis bloodstream infections and define the true burden of the ongoing antifungal resistance.
Dina Yamin, Mutiat Hammed Akanmu, Abbas Al Mutair, Saad Alhumaid, Ali A. Rabaan, Khalid Hajissa   +5 more
doaj   +1 more source

Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata

Microbiology Spectrum, 2022
Candida glabrata is poised to adapt to drug pressure rapidly and acquire antifungal resistance leading to therapeutic failure. Given the limited antifungal armamentarium, there is an unmet need to explore new targets or therapeutic strategies for ...
Shuying Yu, Padmaja Paderu, Annie Lee, Sami Eirekat, Kelley Healey, Liang Chen, David S. Perlin, Yanan Zhao   +7 more
doaj   +1 more source

Fungal biofilm resistance [PDF]

, 2012
Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Ramage, Gordon, Williams, Craig, Rajendran, Ranjith, Ranjith Rajendran, Gordon Ramage, Leighann Sherry, Sherry, Leighann, Craig Williams   +7 more
core   +1 more source

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon, Lopez-Ribot, J.L., Rajendran Ranjith, Ramage, G., Leah E. Cowen, Uppuluri Priya, Robbins, N., Priya Uppuluri, Rajendran, R., Andes, D., Jose L Lopez-Ribot, David Andes, Leah E Cowen, Nicole Robbins, Uppuluri, P., Robbins Nicole, Nett Jeniel, Lopez-Ribot Jose L., Jose L. Lopez-Ribot, Cowen, L.E., Nett, J., Ranjith Rajendran, Gordon Ramage, Jeniel Nett, Andes David, Cowen Leah E.   +25 more
core   +1 more source

Antifungal Resistance in Pathogenic Fungi [PDF]

Clinical Infectious Diseases, 2002
Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of
Sofia, Perea, Thomas F, Patterson
openaire   +2 more sources

Antifungal drug resistance: an update [PDF]

European Journal of Hospital Pharmacy, 2022
The number of antifungal classes is small, and resistance is becoming a much more frequent problem. Much greater emphasis needs to be placed on susceptibility testing and antifungal stewardship. Such efforts demonstrably improve survival and overall clinical outcomes.
openaire   +3 more sources

Emerging threats in antifungal-resistant fungal pathogens

Frontiers in Medicine, 2016
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of antifungal resistance. Resistance has been described for virtually all antifungal agents in diverse pathogens including Candida and Aspergilli species.
Dominique eSanglard
doaj   +1 more source