Results 11 to 20 of about 190,632 (309)
Antifungal resistance, combinations and pipeline: oh my!
Drugs in Context, 2023 Invasive fungal infections are a strong contributor to healthcare costs, morbidity and mortality, especially amongst hospitalized patients. Historically, Candida was responsible for approximately 15% of all nosocomial bloodstream infections.
Kayla R Stover +4 more
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Overcoming antifungal resistance [PDF]
Drug Discovery Today: Technologies, 2014 Fungal infections have become one of the major causes of morbidity and mortality in immunocompromised patients. Despite increased awareness and improved treatment strategies, the frequent development of resistance to the antifungal drugs used in clinical settings contributes to the increasing toll of mycoses.
Anand, Srinivasan +2 more
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Antifungal resistance and clinical significance in small animals
German Journal of Veterinary Research, 2022 Fungal diseases have risen in conjunction with the increasing number of immunosuppressive diseases in human and animal populations. Despite the introduction of new antifungal agents in recent years, the incidence of fungal infections continues to ...
Yasemin Kaya +3 more
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The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi
Microorganisms, 2023 The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment.
Kylie J. Boyce
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MARDy: Mycology Antifungal Resistance Database [PDF]
Bioinformatics, 2018 Abstract Summary The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance.
Anthony Nash +6 more
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Fungal infections: Pathogenesis, antifungals and alternate treatment approaches
Current Research in Microbial Sciences, 2022 Increasing incidence of fungal infections of recent times requires immediate intervention. Fungal infections are seldom construed at initial stages that intensify the severity of infections and complicate the treatment procedures. Fungal pathogens employ
G.Kiran Kumar Reddy +2 more
doaj +1 more source
Molecular Mechanisms of Antifungal Drug Resistance in Candida Species [PDF]
Journal of Clinical and Diagnostic Research, 2018 Invasive Candidal infections have emerged as one of the major threats to the world. Although, many new antifungal drugs have been developed in the recent years, the emergence of drug resistance has become a major deterrent in the antifungal therapy ...
Lakshmi Krishnasamy +3 more
doaj +1 more source
Tropical Medicine and Infectious Disease, 2022 A reliable estimate of Candida parapsilosis antifungal susceptibility in candidemia patients is increasingly important to track the spread of C. parapsilosis bloodstream infections and define the true burden of the ongoing antifungal resistance.
Dina Yamin +5 more
doaj +1 more source
Histone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata
Microbiology Spectrum, 2022 Candida glabrata is poised to adapt to drug pressure rapidly and acquire antifungal resistance leading to therapeutic failure. Given the limited antifungal armamentarium, there is an unmet need to explore new targets or therapeutic strategies for ...
Shuying Yu +7 more
doaj +1 more source
Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]
, 2010 Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Nandkumar M. Kamat +1 more
core +2 more sources