Results 41 to 50 of about 81,126 (158)

Fungal plasticity drives adaptation and survival across pathogenic and free-living contexts

Discover Life
Fungal dynamicity drives rapid adaptation to environmental changes, contributing to the development of antifungal resistance, phenotypic switching, and the emergence of opportunistic pathogenicity.
Tedros Gebrezgiabhier Gebreyesus
doaj   +1 more source

Emergence of fluconazole-resistant candida infections in diabetic foot ulcers: Implications for public health

Indian Journal of Community Medicine, 2019
Background: It is well documented in the literature that fungal infections are common in diabetic foot ulcers (DFUs). This has led to an overuse of antifungal agents, namely fluconazole, with a consequent risk of emergence of resistance to this drug ...
Chankramath S Arun, Priyanka Raju, Vivek Lakshmanan, Anil Kumar, Arun Bal, Harish Kumar   +5 more
doaj   +1 more source

In vitro sensitivity of Malassezia furfur isolates from HIV-positive and negative patients to antifungal agents

Biomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Malassezia is a lipophilic and lipid-dependent yeast genus belonging to the skin microbiota of humans and other animals. However, due to dysbiosis processes or other factors in the host, this yeast can cause different pathologies, ranging ...
Kevin Ehemann, Andrés Contreras, Adriana Marcela Celis-Ramírez   +2 more
doaj   +1 more source

Drug resistant fungal infections An emerging threat

Journal of Dhaka National Medical College & Hospital, 2018
Drug resistance has become an important problem leading to significant negative social, psychological, and occupational health effects and quality of life. Clinical failure and relapses have been observed in patients treated with antifungal drugs. Now a days, Antifungal drug resistance is becoming an emerging threat in management of fungal infections ...
Wazeda Begum, Md Saiful Kabir, Md Maruf Ur Rahman, Md Mostafizur Rahman   +3 more
openaire   +1 more source

Flipping and other astonishing transporter dance moves in fungal drug resistance

BioEssays, 2022
AbstractIn all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR) subfamily confer antibiotic resistance and so are of interest as therapeutic targets.
Raschka, Stefanie L, Harris, Andrzej, Luisi, Ben F, Schmitt, Lutz   +3 more
openaire   +2 more sources

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. [PDF]

PLoS Genetics, 2013
The evolution of drug resistance in fungal pathogens compromises the efficacy of the limited number of antifungal drugs. Drug combinations have emerged as a powerful strategy to enhance antifungal efficacy and abrogate drug resistance, but the impact on ...
Jessica A Hill, Ron Ammar, Dax Torti, Corey Nislow, Leah E Cowen   +4 more
doaj   +1 more source

Nanoemulsion as an Effective Treatment against Human-Pathogenic Fungi

mSphere, 2019
Infections triggered by pathogenic fungi cause a serious threat to the public health care system. In particular, an increase of antifungal drug-resistant fungi has resulted in difficulty in treatment.
Alexis Garcia, Yong Yi Fan, Sandeep Vellanki, Eun Young Huh, DiFernando Vanegas, Su He Wang, Soo Chan Lee   +6 more
doaj   +1 more source

The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress.

PLoS Pathogens, 2023
Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Ka Pui Sharon Yau, Harshini Weerasinghe, Francios A B Olivier, Tricia L Lo, David R Powell, Barbara Koch, Traude H Beilharz, Ana Traven   +7 more
doaj   +1 more source

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. [PDF]

PLoS Pathogens, 2010
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening ...
Shantelle L LaFayette, Cathy Collins, Aimee K Zaas, Wiley A Schell, Marisol Betancourt-Quiroz, A A Leslie Gunatilaka, John R Perfect, Leah E Cowen   +7 more
doaj   +1 more source

Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies

Turkish Journal of Hematology, 2018
Invasive fungal infections caused by drug-resistant organisms are an emerging threat to heavily immunosuppressed patients with hematological malignancies.
Maria N. Gamaletsou, Thomas J. Walsh, Nikolaos V. Sipsas   +2 more
doaj   +1 more source