Results 51 to 60 of about 4,538,104 (325)
Linking calcium signaling and mitochondrial function in fungal drug resistance [PDF]
Proceedings of the National Academy of Sciences, 2020 The host range for Aspergillus fumigatus is wide, including mammals, aves, and insecta (stonebrood). This is linked to the significant adaptability of this important fungal pathogen. It is thermotolerant, able to grow up to 70 °C, and astonishingly also remains viable down to −20 °C (1).
Paul Bowyer +2 more
openaire +3 more sources
In vitro susceptibility of Cuban Aspergillus spp. strains of clinical and environmental origin
Biomédica: revista del Instituto Nacional de Salud, 2017 Introduction: The behavior of antifungal susceptibility of Aspergillus spp. in Cuba remains unknown. The antifungals recommended to treat aspergillosis are amphotericin B, itraconazole, voriconazole and echinocandins. The influence of the environment may
Javier L. San Juan +6 more
doaj +1 more source
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]
, 2016 Objectives The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. Methods Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Kelner, Anna +5 more
core +1 more source
Nature CommunicationsThe rise of drug-resistant fungal species, such as Candida auris, poses a serious threat to global health, with mortality rates exceeding 40% and resistance rates surpassing 90%.
Yuping Zhang +16 more
semanticscholar +1 more source
Virulence, 2017 Increases in the incidence and mortality due to the major invasive fungal infections such as aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida and Cryptococcus, are a growing threat to the immunosuppressed ...
Praveen R. Juvvadi +3 more
semanticscholar +1 more source
Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]
, 2004 Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR +5 more
core +1 more source
Microbial Cell, 2016 Human fungal infections are increasing in prevalence and acquisition of antifungal drug resistance, while our antifungal drug armamentarium remains very limited, constituting a significant public health problem. Despite the fact that prominent antifungal
Erika Shor +3 more
doaj +1 more source
Antifungal drug-resistance mechanisms in Candida biofilms
Current Opinion in Microbiology, 2022 Infections caused by the Candida species of human fungal pathogens are a significant medical problem because they can disseminate to nearly every organ of the body. In addition, there are only a few classes of antifungal drugs available to treat patients
Jaspreet Kaur, Clarissa J. Nobile
semanticscholar +1 more source
Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi [PDF]
, 2008 Background: In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely.
Borelli, Claudia +10 more
core +1 more source
Drug Resistance and Evolvability in an Emerging Human Fungal Pathogen
mBio, 2022 Over the past decade, Candida auris has emerged as a highly transmissible human fungal pathogen. Because of its ability to transmit between patients in hospitals and its ability to rapidly develop drug resistance, C. auris presents unique challenges.
openaire +3 more sources