Results 71 to 80 of about 4,538,104 (325)

Melanin's Role in Balancing Mechanical Strength and Reproductive Output in Environmentally Stressed Fungal Spores

Advanced Functional Materials, EarlyView.
Melanin content directly controls fungal spore mechanical properties, with pigmented spores achieving rupture forces two orders of magnitude higher than hyaline spores. Environmental stress drives this quantity‐quality tradeoff; stressed species invest energy in melanin‐reinforced, mechanically superior thick‐walled, super‐hydrophobic spores, while ...
Atul Agrawal, Steven E. Naleway
wiley   +1 more source

MOLECULAR MECHANISMS OF DRUG RESISTANCE IN CANDIDA ALBICANS: ROLE OF TRANSCRIPTION FACTORS MCM1 AND ADA2 [PDF]

, 2011
Candida albicans is an opportunistic fungal pathogen responsible for localized as well as disseminated infections. C. albicans is the most commonly isolated specie from blood cultures, accounting for over 60% of all Candida isolates. The fungistatic drug
MOGAVERO, SELENE
core  

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

Mediators of Inflammation, 2017
Diseases caused by fungi can occur in healthy people, but immunocompromised patients are the major risk group for invasive fungal infections. Cases of fungal resistance and the difficulty of treatment make fungal infections a public health problem.
Juliana Alves Parente-Rocha, Alexandre Melo Bailão, André Correa Amaral, Carlos Pelleschi Taborda, Juliano Domiraci Paccez, Clayton Luiz Borges, Maristela Pereira   +6 more
doaj   +1 more source

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

Nature Communications, 2016
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
K. Healey, Yanan Zhao, Winder B. Perez, S. Lockhart, J. Sobel, D. Farmakiotis, D. Kontoyiannis, D. Sanglard, S. Taj-Aldeen, B. Alexander, Cristina Jimenez-Ortigosa, E. Shor, D. Perlin   +12 more
semanticscholar   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease [PDF]

Microbiology and Molecular Biology Reviews, 2011
SUMMARYPathogenic fungi have become a leading cause of human mortality due to the increasing frequency of fungal infections in immunocompromised populations and the limited armamentarium of clinically useful antifungal drugs.Candida albicans,Cryptococcus neoformans, andAspergillus fumigatusare the leading causes of opportunistic fungal infections.
Rebecca S, Shapiro, Nicole, Robbins, Leah E, Cowen   +2 more
openaire   +2 more sources

Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis

Frontiers in Cellular and Infection Microbiology, 2021
Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida ...
Sarah E. Murphy, T. Bicanic
semanticscholar   +1 more source

Adsorbent Materials for Hydrocarbons Removal by Geopolymerization of Halloysite Clay Nanotubes Filled Within Chitosan Matrix

Advanced Materials Interfaces, EarlyView.
Alkaline activation of halloysite clay nanotubes embedded in a chitosan matrix converts bionanocomposite films into porous geopolymeric materials with enhanced adsorption capacity toward hydrocarbons in both vapor and aqueous phases. The improved adsorption performance was demonstrated by the efficient capture of dodecane vapors and phenol from water ...
Alessandro Lo Bianco, Marta Giuseppina Ebbreo, Giuseppe Cavallaro, Martina Maria Calvino, Yafei Zhao, Simonpietro Agnello, Giuseppe Lazzara   +6 more
wiley   +1 more source

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

Cell Reports, 2012
The molecular chaperone Hsp90 is a hub of protein homeostasis and regulatory circuitry. Hsp90 function is regulated by posttranslational modifications including acetylation in mammals; however, whether this regulation is conserved remains unknown.
Nicole Robbins, Michelle D. Leach, Leah E. Cowen   +2 more
doaj   +1 more source

Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches

Infection and Drug Resistance, 2021
Candidemia and invasive candidiasis are the most common healthcare-associated invasive fungal infections, with a crude mortality rate of 25–50%. Candida albicans remains the most frequent etiology, followed by C. glabrata, C.
A. Tortorano, A. Prigitano, G. Morroni, L. Brescini, F. Barchiesi   +4 more
semanticscholar   +1 more source