Results 61 to 70 of about 84,689 (291)

The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus. [PDF]

, 2012
Two-component signaling systems are widespread in bacteria, but also found in fungi. In this study, we have characterized TcsC, the only Group III two-component sensor kinase of Aspergillus fumigatus. TcsC is required for growth under hyperosmotic stress,
Ilse D. Jacobsen (149635), Beck, Julia, Marzena Broniszewska (160482), Jacobsen, Ilse D., Julia Beck, Beck Julia, Ebel, Frank, Jürgen Heesemann, Allison McCormick, Jacobsen Ilse D., Broniszewska Marzena, Heesemann Jürgen, Ilse D Jacobsen, Broniszewska, Marzena, Frank Ebel (160490), Julia Beck (160485), McCormick Allison, Allison McCormick (160475), Ebel Frank, Frank Ebel, Jürgen Heesemann (4231), Heesemann, Jürgen, Marzena Broniszewska, McCormick, Allison   +23 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections

, 2023
Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance ...
Caroline Patini Rezende, Leonardo Martins-Santana, Antonio Rossi, Fausto Almeida, Nilce Maria Martinez-Rossi   +4 more
core   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Emergence of fluconazole-resistant candida infections in diabetic foot ulcers: Implications for public health

Indian Journal of Community Medicine, 2019
Background: It is well documented in the literature that fungal infections are common in diabetic foot ulcers (DFUs). This has led to an overuse of antifungal agents, namely fluconazole, with a consequent risk of emergence of resistance to this drug ...
Chankramath S Arun, Priyanka Raju, Vivek Lakshmanan, Anil Kumar, Arun Bal, Harish Kumar   +5 more
doaj   +1 more source

Synthetic biology of fungal natural products

, 2015
This work was supported by the DFG-funded excellence graduate school Jena School for Microbial Communication (JSMC; DJM, AAB), the collaborative research center (SFB) 1127 Chemical Mediators in Complex Biosystems (ChemBioSys—AAB, project B02) and the ...
Vito Valiante, Unkles, S.E., Mattern, D.J., Valiante, V., Brakhage, A.A., Derek J. Mattern, Axel A. Brakhage, Shiela E. Unkles   +7 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Fungal plasticity drives adaptation and survival across pathogenic and free-living contexts

Discover Life
Fungal dynamicity drives rapid adaptation to environmental changes, contributing to the development of antifungal resistance, phenotypic switching, and the emergence of opportunistic pathogenicity.
Tedros Gebrezgiabhier Gebreyesus
doaj   +1 more source

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. [PDF]

PLoS Genetics, 2013
The evolution of drug resistance in fungal pathogens compromises the efficacy of the limited number of antifungal drugs. Drug combinations have emerged as a powerful strategy to enhance antifungal efficacy and abrogate drug resistance, but the impact on ...
Jessica A Hill, Ron Ammar, Dax Torti, Corey Nislow, Leah E Cowen   +4 more
doaj   +1 more source

Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development

, 2019
Invasive fungal infections (IFI) are an increasing threat to the developing world, with fungal spores being ubiquitous and inhaled every day. Some fungal species are commensal organisms that are part of the normal human microbiota, and, as such, do not ...
Lee, Danielle J, Thomas Haselhorst, Danielle J. Lee, Haselhorst, Thomas, Françoise H. Routier, Holly O’Donnell, Tiralongo, Joe, Routier, Francoise H, Joe Tiralongo, O'Donnell, Holly   +9 more
core   +1 more source