Results 31 to 40 of about 81,126 (158)
Microbial Cell, 2016 Human fungal infections are increasing in prevalence and acquisition of antifungal drug resistance, while our antifungal drug armamentarium remains very limited, constituting a significant public health problem. Despite the fact that prominent antifungal
Erika Shor +3 more
doaj +1 more source
Drug Resistance and Evolvability in an Emerging Human Fungal Pathogen
mBio, 2022 Over the past decade, Candida auris has emerged as a highly transmissible human fungal pathogen. Because of its ability to transmit between patients in hospitals and its ability to rapidly develop drug resistance, C. auris presents unique challenges.
openaire +3 more sources
Linking Cellular Morphogenesis with Antifungal Treatment and Susceptibility in Candida Pathogens
Journal of Fungi, 2019 Fungal infections are a growing public health concern, and an increasingly important cause of human mortality, with Candida species being amongst the most frequently encountered of these opportunistic fungal pathogens.
Jehoshua Sharma +3 more
doaj +1 more source
Candida auris: An Overview of the Emerging Drug-Resistant Fungal Infection
Infection & Chemotherapy, 2022 Candida auris is an invasive fungal pathogen that has been recognized globally as a serious health threat due to its extensive innate and acquired resistance to antifungal drugs. A growing number of emerging cases of C. auris have been reported with resistance to the standard antifungal treatments including azoles, echinocandins, and polyenes, making ...
Adekunle Sanyaolu +8 more
openaire +2 more sources
Prevalence of Fungal Drug Resistance in COVID-19 Infection: a Global Meta-analysis
Current Fungal Infection Reports, 2022 Secondary bacterial or fungal infections are one of the most important medical complications among patients with Coronavirus Disease 2019 (COVID-19). The emergence of multidrug-resistant (MDR) candida can cause many problems such as treatment failure, adverse clinical outcomes, and even disease outbreaks.
Habibzadeh, Adrina +9 more
openaire +3 more sources
mSphere of Influence: Rapid evolution of pathogenesis and drug resistance in human pathogenic fungi
mSpherePengjie Hu works in the field of fungal pathogenesis, drug resistance, and evolution. In this mSphere of Influence article, he reflects on how three works, “Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection ...
Pengjie Hu
doaj +1 more source
The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors [PDF]
Frontiers in Microbiology, 2019 CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice. In recent years, researches on fungal CYP51 have stepped into a new stage attributing to the discovery of crystal ...
Jingxiang Zhang +8 more
openaire +3 more sources
Mediators of Inflammation, 2017 Diseases caused by fungi can occur in healthy people, but immunocompromised patients are the major risk group for invasive fungal infections. Cases of fungal resistance and the difficulty of treatment make fungal infections a public health problem.
Juliana Alves Parente-Rocha +6 more
doaj +1 more source
Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease [PDF]
Microbiology and Molecular Biology Reviews, 2011 SUMMARYPathogenic fungi have become a leading cause of human mortality due to the increasing frequency of fungal infections in immunocompromised populations and the limited armamentarium of clinically useful antifungal drugs.Candida albicans,Cryptococcus neoformans, andAspergillus fumigatusare the leading causes of opportunistic fungal infections.
Rebecca S, Shapiro +2 more
openaire +2 more sources
Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance
Cell Reports, 2012 The molecular chaperone Hsp90 is a hub of protein homeostasis and regulatory circuitry. Hsp90 function is regulated by posttranslational modifications including acetylation in mammals; however, whether this regulation is conserved remains unknown.
Nicole Robbins +2 more
doaj +1 more source