Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Antibiotics, 2020 The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar +8 more
doaj +1 more source
Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]
, 2012 The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller +40 more
core +4 more sources
Antifungal resistance in dermatology
Indian Journal of Dermatology, 2018 Cutaneous fungal infections affect more than one-fourth of world's population. The pathogenesis and severity of fungal infection depend on various immunological and nonimmunological factors.
Varadraj Pai +2 more
doaj +1 more source
Fungal biofilm resistance [PDF]
, 2012 Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Ramage, Gordon +7 more
core +1 more source
Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]
, 2010 Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Sonashia Velho-Pereira +1 more
core +1 more source
The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens [PDF]
Journal of Fungi, 2020 Human fungal pathogens are attributable to a significant economic burden and mortality worldwide. Antifungal treatments, although limited in number, play a pivotal role in decreasing mortality and morbidities posed by invasive fungal infections (IFIs). However, the recent emergence of multidrug-resistant Candida auris and Candida glabrata and acquiring
Amir Arastehfar +7 more
openaire +5 more sources
The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi
Microorganisms, 2023 The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment.
Kylie J. Boyce
doaj +1 more source
Coordination of fungal biofilm development by extracellular vesicle cargo
Nature Communications, 2021 The fungal pathogen Candida albicans can release extracellular vesicles that promote biofilm formation and antifungal resistance. Here, Zarnowski et al.
Robert Zarnowski +11 more
doaj +1 more source
Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
Journal of Infection and Public Health, 2023 In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector ...
Ali A. Rabaan +18 more
doaj +1 more source
Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in
mBio, 2016 Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited.
Wei Huang +7 more
doaj +1 more source