Results 21 to 30 of about 4,538,104 (325)

Antifungal resistance in dermatophytosis: A global health concern

Letters in Animal Biology, 2022
Dermatophytosis is a common dermatological problem in animals as well as humans which is associated with interference in immune function. Unlike the antibacterial resistance which is frequently reported, antifungal resistance is less commonly reported ...
Jubeda Begum, P Das
doaj   +1 more source

Filamentous fungal biofilms: Conserved and unique aspects of extracellular matrix composition, mechanisms of drug resistance and regulatory networks in Aspergillus fumigatus

npj Biofilms and Microbiomes, 2022
The filamentous fungus Aspergillus fumigatus is an ubiquitous mold that can cause invasive pulmonary infections in immunocompromised patients. Within the lung, A.
Shuai-Mei Liu, François Le Mauff, D. Sheppard, Shi-Zhu Zhang   +3 more
semanticscholar   +1 more source

Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens

Biochemical Society Transactions, 2022
Fungal pathogens pose an increasingly worrying threat to human health, food security and ecosystem diversity. To tackle fungal infections and improve current diagnostic and therapeutic tools it is necessary to understand virulence and antifungal drug ...
Miquel Àngel Schikora-Tamarit, T. Gabaldón   +1 more
semanticscholar   +1 more source

The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. [PDF]

PLoS ONE, 2012
The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90 functions in concert with co-chaperones to regulate stability and activation of client proteins ...
Rebecca S Shapiro, Aimee K Zaas, Marisol Betancourt-Quiroz, John R Perfect, Leah E Cowen   +4 more
doaj   +1 more source

The metal chaperone protein MtmA plays important roles in antifungal drug susceptibility in Aspergillus fumigatus

Frontiers in Microbiology, 2022
Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence.
Pengfei Zhai, Yinyan Ma, Wenlong Du, Ling Lu   +3 more
doaj   +1 more source

Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans

mBio, 2023
Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance.
Juliana Rizzo, Adèle Trottier, Frédérique Moyrand, Jean-Yves Coppée, Corinne Maufrais, Ana Claudia G. Zimbres, Thi Tuong Vi Dang, Alexandre Alanio, Marie Desnos-Ollivier, Isabelle Mouyna, Gérard Péhau-Arnaude, Pierre-Henri Commere, Sophie Novault, Iuliana V. Ene, Leonardo Nimrichter, Marcio L. Rodrigues, Guilhem Janbon   +16 more
doaj   +1 more source

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

mSphere, 2021
Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida ...
Golnoush Madani, Erwin Lamping, Richard D. Cannon   +2 more
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +5 more sources

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

Antibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar, Toni Gabaldón, Rocio Garcia-Rubio, Jeffrey D. Jenks, Martin Hoenigl, Helmut J. F. Salzer, Macit Ilkit, Cornelia Lass-Flörl, David S. Perlin   +8 more
doaj   +1 more source

Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review

Antibiotics, 2023
Fungal infections are becoming one of the main causes of morbidity and mortality in people with weakened immune systems. Mycoses are becoming more common, despite greater knowledge and better treatment methods, due to the regular emergence of resistance ...
Ali A. Rabaan, Tarek Sulaiman, Shamsah H. Al-Ahmed, Zainab A. Buhaliqah, Ali A. Buhaliqah, Buthina AlYuosof, Mubarak Alfaresi, Mona A. Al Fares, Sara Alwarthan, Mohammed S. Alkathlan, Reem S. Almaghrabi, Abdulmonem A. Abuzaid, Jaffar A. Altowaileb, Maha Al Ibrahim, Eman M. AlSalman, Fatimah Alsalman, Mohammad Alghounaim, Ahmed S. Bueid, Awad Al-Omari, Ranjan K. Mohapatra   +19 more
doaj   +1 more source