The Microevolution of Antifungal Drug Resistance in Pathogenic Fungi
Microorganisms, 2023 The mortality rates of invasive fungal infections remain high because of the limited number of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during treatment.
Kylie J. Boyce
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Coordination of fungal biofilm development by extracellular vesicle cargo
Nature Communications, 2021 The fungal pathogen Candida albicans can release extracellular vesicles that promote biofilm formation and antifungal resistance. Here, Zarnowski et al.
Robert Zarnowski +11 more
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Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
Journal of Infection and Public Health, 2023 In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector ...
Ali A. Rabaan +18 more
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Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in
mBio, 2016 Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited.
Wei Huang +7 more
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Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]
PLoS Pathogens, 2012 The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak +9 more
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Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance [PDF]
Eukaryotic Cell, 2008 The survival of all organisms depends critically upon interactions with the environment, mediated largely through the action of small molecules. Small molecules can provide the nutrients to support life ([195][1]), mediate communication between organisms ([25][2], [76][3], [238][4]), or ...
Leah E, Cowen, William J, Steinbach
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Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery [PDF]
Antibiotics, 2020 Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted in the Centers for Disease Control and Prevention’s (CDC) 2019 report, Antibiotic Resistance Threats ...
Lewis Marquez, Cassandra L. Quave
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Linking calcium signaling and mitochondrial function in fungal drug resistance [PDF]
Proceedings of the National Academy of Sciences, 2020 The host range for Aspergillus fumigatus is wide, including mammals, aves, and insecta (stonebrood). This is linked to the significant adaptability of this important fungal pathogen. It is thermotolerant, able to grow up to 70 °C, and astonishingly also remains viable down to −20 °C (1).
Paul Bowyer +2 more
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In vitro susceptibility of Cuban Aspergillus spp. strains of clinical and environmental origin
Biomédica: revista del Instituto Nacional de Salud, 2017 Introduction: The behavior of antifungal susceptibility of Aspergillus spp. in Cuba remains unknown. The antifungals recommended to treat aspergillosis are amphotericin B, itraconazole, voriconazole and echinocandins. The influence of the environment may
Javier L. San Juan +6 more
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Antifungals and Drug Resistance
Encyclopedia, 2022 Antifungal drugs prevent topical or invasive fungal infections (mycoses) either by stopping growth of fungi (termed fungistatic) or by killing the fungal cells (termed fungicidal).
Chowdhury Mobaswar Hossain +6 more
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