Results 11 to 20 of about 81,126 (158)

Fungal Biofilms and Drug Resistance

Emerging Infectious Diseases, 2004
Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring ...
Mary Ann Jabra-Rizk, William A. Falkler, Timothy F. Meiller   +2 more
doaj   +4 more sources

Hsp90 governs dispersion and drug resistance of fungal biofilms. [PDF]

PLoS Pathogens, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Nicole Robbins, Priya Uppuluri, Jeniel Nett, Ranjith Rajendran, Gordon Ramage, Jose L Lopez-Ribot, David Andes, Leah E Cowen   +7 more
doaj   +5 more sources

Virulence Regulation and Drug-Resistance Mechanism of Fungal Infection

Microorganisms, 2022
In this issue, I propose promising developments in the field of the mechanism of virulence factors that can be linked to antifungal resistance [...]
Letizia Angiolella
doaj   +3 more sources

Fungal Cell Wall: Emerging Antifungals and Drug Resistance [PDF]

Frontiers in Microbiology, 2019
The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima, Arnaldo L. Colombo, João N. de Almeida Junior   +2 more
doaj   +3 more sources

Deciphering the role of mitochondria in human fungal drug resistance

Mycology
As pathogenic fungi increasingly threaten public health, particularly in immunocompromised populations, understanding the mechanisms behind fungal drug resistance has become critical.
Yuanyuan Ma, Yachun Zhou, Tianyuan Jia, Zilin Zhuang, Peng Xue, Liang Yang   +5 more
doaj   +4 more sources

Fungal Biofilms, Drug Resistance, and Recurrent Infection [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to ...
Jigar V, Desai, Aaron P, Mitchell, David R, Andes   +2 more
openaire   +2 more sources

Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review

Antibiotics, 2023
Fungal infections are becoming one of the main causes of morbidity and mortality in people with weakened immune systems. Mycoses are becoming more common, despite greater knowledge and better treatment methods, due to the regular emergence of resistance ...
Ali A. Rabaan, Tarek Sulaiman, Shamsah H. Al-Ahmed, Zainab A. Buhaliqah, Ali A. Buhaliqah, Buthina AlYuosof, Mubarak Alfaresi, Mona A. Al Fares, Sara Alwarthan, Mohammed S. Alkathlan, Reem S. Almaghrabi, Abdulmonem A. Abuzaid, Jaffar A. Altowaileb, Maha Al Ibrahim, Eman M. AlSalman, Fatimah Alsalman, Mohammad Alghounaim, Ahmed S. Bueid, Awad Al-Omari, Ranjan K. Mohapatra   +19 more
doaj   +1 more source

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

Antibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar, Toni Gabaldón, Rocio Garcia-Rubio, Jeffrey D. Jenks, Martin Hoenigl, Helmut J. F. Salzer, Macit Ilkit, Cornelia Lass-Flörl, David S. Perlin   +8 more
doaj   +1 more source

Antifungal resistance in dermatology

Indian Journal of Dermatology, 2018
Cutaneous fungal infections affect more than one-fourth of world's population. The pathogenesis and severity of fungal infection depend on various immunological and nonimmunological factors.
Varadraj Pai, Ajantha Ganavalli, Naveen Narayanshetty Kikkeri   +2 more
doaj   +1 more source

The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens [PDF]

Journal of Fungi, 2020
Human fungal pathogens are attributable to a significant economic burden and mortality worldwide. Antifungal treatments, although limited in number, play a pivotal role in decreasing mortality and morbidities posed by invasive fungal infections (IFIs). However, the recent emergence of multidrug-resistant Candida auris and Candida glabrata and acquiring
Amir Arastehfar, Cornelia Lass-Flörl, Rocio Garcia-Rubio, Farnaz Daneshnia, Macit Ilkit, Teun Boekhout, Toni Gabaldon, David S. Perlin   +7 more
openaire   +5 more sources