Results 11 to 20 of about 4,538,104 (325)
Hsp90 governs dispersion and drug resistance of fungal biofilms. [PDF]
PLoS Pathogens, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Nicole Robbins +7 more
doaj +7 more sources
Fungal Biofilms and Drug Resistance
Emerging Infectious Diseases, 2004 Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now emerging as major agents of nosocomial infections. Many such manifestations of infections associated with the formation of Candida biofilms include those occurring ...
Mary Ann Jabra-Rizk +2 more
doaj +4 more sources
Prevalence of Fungal Drug Resistance in COVID-19 Infection: a Global Meta-analysis
Current Fungal Infection Reports, 2022 Secondary bacterial or fungal infections are one of the most important medical complications among patients with Coronavirus Disease 2019 (COVID-19). The emergence of multidrug-resistant (MDR) candida can cause many problems such as treatment failure ...
Adrina Habibzadeh +9 more
semanticscholar +4 more sources
Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity
Molecular Microbiology, 2020 In recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and resistance to azole drugs, has been a rapidly growing field.
Jin-Xing Song, Xiao Liu, Rong-Peng Li
semanticscholar +3 more sources
Virulence Regulation and Drug-Resistance Mechanism of Fungal Infection
Microorganisms, 2022 In this issue, I propose promising developments in the field of the mechanism of virulence factors that can be linked to antifungal resistance [...]
Letizia Angiolella
doaj +3 more sources
Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery [PDF]
Antibiotics, 2020 Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted ...
L. Marquez, C. Quave
semanticscholar +4 more sources
The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors [PDF]
Frontiers in Microbiology, 2019 CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice.
Jingxiang Zhang +5 more
semanticscholar +4 more sources
Deciphering the role of mitochondria in human fungal drug resistance
MycologyAs pathogenic fungi increasingly threaten public health, particularly in immunocompromised populations, understanding the mechanisms behind fungal drug resistance has become critical.
Yuanyuan Ma +5 more
doaj +4 more sources
Fungal biofilms, drug resistance, and recurrent infection. [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to ...
Jigar V. Desai, A. Mitchell, D. Andes
semanticscholar +3 more sources
Nature Communications, 2023 Arastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants emerge Candida ...
A. Arastehfar +7 more
semanticscholar +1 more source