Results 11 to 20 of about 15,578 (196)

Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations

Journal of Fungi, 2021
Azole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A.
Irene Gonzalez-Jimenez, Jose Lucio, Maria Dolores Menéndez-Fraga, Emilia Mellado, Teresa Peláez   +4 more
doaj   +1 more source

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene

Frontiers in Microbiology, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Peiying Chen, Musang Liu, Musang Liu, Qiuqiong Zeng, Zheng Zhang, Weida Liu, Weida Liu, Hong Sang, Ling Lu   +8 more
doaj   +1 more source

A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus

Journal of Fungi, 2020
The emergence and spread of Aspergillus fumigatus azole resistance has been acknowledged worldwide. The main problem of azole resistance is the limited therapeutic options for patients suffering aspergillosis. Azole resistance mechanisms have been mostly
Irene Gonzalez-Jimenez, Jose Lucio, Jorge Amich, Isabel Cuesta, Rafael Sanchez Arroyo, Laura Alcazar-Fuoli, Emilia Mellado   +6 more
doaj   +1 more source

Invasive Aspergillosis and the Impact of Azole-resistance

Current Fungal Infection Reports, 2023
Abstract   Purpose of Review IA (invasive aspergillosis) caused by azole-resistant strains has been associated with higher clinical burden and mortality rates. We review the current epidemiology, diagnostic, and therapeutic strategies of this clinical entity, with a special focus on patients with hematologic malignancies.
Bosetti, Davide, Neofytos, Dionysios
openaire   +2 more sources

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

Molecules, 2021
Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates.
Irene Gonzalez-Jimenez, Jose Lucio, Alejandra Roldan, Laura Alcazar-Fuoli, Emilia Mellado   +4 more
doaj   +1 more source

Unmasking of CgYor1-Dependent Azole Resistance Mediated by Target of Rapamycin (TOR) and Calcineurin Signaling in Candida glabrata

mBio, 2022
In this study, 18 predicted membrane-localized ABC transporters of Candida glabrata were deleted individually to create a minilibrary of knockouts (KO). The transporter KOs were analyzed for their susceptibility toward antimycotic drugs.
Sonam Kumari, Mohit Kumar, Brooke D. Esquivel, Mohd Wasi, Ajay Kumar Pandey, Nitesh Kumar Khandelwal, Alok K. Mondal, Theodore C. White, Rajendra Prasad, Naseem A. Gaur   +9 more
doaj   +1 more source

Azole resistance inCandida

European Journal of Clinical Microbiology & Infectious Diseases, 1997
Resistance of Candida to azoles is an increasing problem. Susceptibility testing of Candida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis.
Denning, D.W.; id_orcid 0000-0001-5626-2251, Baily, G.G., Hood, S.V.   +2 more
openaire   +4 more sources

A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence

mBio, 2017
This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed.
Jianhua Zhang, Eveline Snelders, Bas J. Zwaan, Sijmen E. Schoustra, Jacques F. Meis, Karin van Dijk, Ferry Hagen, Martha T. van der Beek, Greetje A. Kampinga, Jan Zoll, Willem J. G. Melchers, Paul E. Verweij, Alfons J. M. Debets   +12 more
doaj   +1 more source

Impact of TR₃₄/L98H, TR₄₆/Y121F/T289A and TR₅₃ Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Microorganisms, 2022
Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis.
Rose-Anne Lavergne, Marjorie Albassier, Jean-Benoît Hardouin, Carlos Alvarez-Moreno, Fabrice Pagniez, Florent Morio, Patrice Le Pape, Isabelle Ourliac-Garnier   +7 more
doaj   +1 more source

Azole Resistance in Candida Spp.

Nippon Ishinkin Gakkai Zasshi, 2003
The emergence of azole-resistant Candida spp. is a significant problem after long-term treatment of recurrent oropharyngeal candidiasis in HIV-infected patients. Several mechanisms can cause this resistance. An important mechanism of azole resistance is reduced intracellular accumulation of the drug.
Kakeya, Hiroshi, Miyazaki, Taiga, Miyazaki, Yoshitsugu, Kohno, Shigeru   +3 more
openaire   +3 more sources